- Drug Delivery to the Suprachoroidal Space

2012 ◽  
pp. 252-275 ◽  
Keyword(s):  
Drug Delivery ◽  
Suprachoroidal Space

scholarly journals Targeting drug delivery within the suprachoroidal space

2019 ◽  
Vol 24 (8) ◽  
pp. 1654-1659 ◽  
Author(s):  
Jae Hwan Jung ◽  
J. Jeremy Chae ◽  
Mark R. Prausnitz
Keyword(s):  
Drug Delivery ◽  
Suprachoroidal Space

scholarly journals Drug Delivery via the Suprachoroidal Space for the Treatment of Retinal Diseases

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 967
Author(s):  
Liron Naftali Ben Haim ◽  
Elad Moisseiev
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Macular Edema ◽  
Viral Vectors ◽  
Delivery Methods ◽  
New Developments ◽  
Suprachoroidal Space ◽  
Advanced Therapies ◽  
Preclinical Trials ◽  
Areas Of Interest

The suprachoroidal space (SCS), a potential space between the sclera and choroid, is becoming an applicable method to deliver therapeutics to the back of the eye. In recent years, a vast amount of research in the field has been carried out, with new discoveries in different areas of interest, such as imaging, drug delivery methods, pharmacokinetics, pharmacotherapies in preclinical and clinical trials and advanced therapies. The SCS can be visualized via advanced techniques of optical coherence tomography (OCT) in eyes with different pathologies, and even in healthy eyes. Drugs can be delivered easily and safely via hollow microneedles fitted to the length of the approximate thickness of the sclera. SCS injections were found to reach greater baseline concentrations in the target layers compared to intravitreal (IVT) injection, while agent clearance was faster with highly aqueous soluble molecules. Clinical trials with SCS injection of triamcinolone acetonide (TA) were executed with promising findings for patients with noninfectious uveitis (NIU), NIU implicated with macular edema and diabetic macular edema (DME). Gene therapy is evolving rapidly with viral and non-viral vectors that were found to be safe and efficient in preclinical trials. Here, we review these novel different aspects and new developments in clinical treatment of the posterior segment of the eye.

Cannulation of the Suprachoroidal Space: A Novel Drug Delivery Methodology to the Posterior Segment

2006 ◽  
Vol 142 (5) ◽  
pp. 777-787.e2 ◽  
Author(s):  
Timothy W. Olsen ◽  
Xiao Feng ◽  
Kathy Wabner ◽  
Stanley R. Conston ◽  
David H. Sierra ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Suprachoroidal Space ◽  
Novel Drug

scholarly journals Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

2012 ◽  
Vol 53 (8) ◽  
pp. 4433 ◽  
Author(s):  
Samirkumar R. Patel ◽  
Damian E. Berezovsky ◽  
Bernard E. McCarey ◽  
Vladimir Zarnitsyn ◽  
Henry F. Edelhauser ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Suprachoroidal Space

scholarly journals Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle

2018 ◽  
Vol 277 ◽  
pp. 14-22 ◽  
Author(s):  
Jae Hwan Jung ◽  
Bryce Chiang ◽  
Hans E. Grossniklaus ◽  
Mark R. Prausnitz
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Suprachoroidal Space

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Sign in / Sign up

Export Citation Format

Share Document