BACKGROUND: The known loss of dopaminergic cells in the pars-compacta of the substantia nigra that is the hallmark of PD. The cellular pathophysiology of the motor dysfunction is beginning to be better understood, thereby providing a stronger scientific rationale for surgical interventions. Yet, to date, there are no treatments that prevent, halt, or cure PD. Surgical strategies, offer symptomatic relief or control of motor complications associated with drug treatment.
Both pallidotomy and thalamotomy were extensively used in the treatment of PD in the1950’s and 1960’s. With the introduction of levodopa (L-dopa) in the1960’s and the realization of its striking benefits, surgery was almost abandoned and used only for patients with severe tremor. Surgical therapy is now being used earlier and more often. There are currently three brain regions being considered as targets for functional neurosurgery for PD (other than transplantation). Either CNS lesions (thalamotomy, pallidotomy or subthalamic nucleus lesions) or deep brain stimulation [DBS]. These targets are: The ventral intermediate nucleus of the thalamus (Vim), the internal segment of the Globus Pallidus (GPi) and the subthalamic nucleus (STN).
OBJECTIVE: To assess the outcome (3 months & 6 months) of lesioning procedures in parkinson’s disease (PD) patients meeting the inclusion criteria.
METHODS: A prospective clinical study conducted on 10 IPD patients during the period from October 2018 to March 2021 at Cairo University Hospitals. This study was concerned to improve the motor symptoms of IPD patients by stereotactic radiofrequency ablative procedures. Cases were restricted to 10 patients due to the Covid-19 pandemic and restriction of elective cases for chronic patients at Cairo University hospitals.
RESULTS: In our study we operated upon 10 IPD patients who were meeting our selection criteria by ablative procedures contralateral to parkinsonian symptoms.
Age of the patients ranged 17 – 70y with mean of 50.5 ± 16.35 y with predominance in males representing 6 patients. Mean duration of Parkinson`s disease according to history ranged from 2 to 12 y with mean of 8 ± 3.1 years. Patients were divided into three groups according to their presentation and the operation done for them. Thalamotomy group: Pre-operatively, the UPDRS III off & on respectively was 24.4/15.2 and post-operatively was 13/7.4 with improvement 47% / 51%. The tremor subscore was 5.4/2.8 pre-operatively and 1.4/0.8 post-operatively with average of 72% improvement. The UPDRS II pre was 17.2/11.6 and post it became 10.6/7 with 39% improvement. Modified H&Y 2.4/1.7 pre & post-operatively (29% improvement). Pallidotomy group: Pre-operatively, the UPDRS III off & on respectively was 38.5/23.5 and post-operatively was 28/16 with improvement 27% / 32%. The rigidity subscore was 5/2.5 pre-operatively and 2/1 post-operatively with average of 60% improvement. The bradykinesia subscore was 9/5.5 pre-operatively and 5.5/2.5 post-operatively with average of 47% improvement. The dyskinesia subscore was 4.5 pre-operatively and 1.2 post-operatively with average of 71% improvement. The UPDRS II pre was 22/12.5 and post it became 16/10 with 25% improvement. Modified H&Y 2.75/2.25 pre & post-operatively (18% improvement). Combined group: Pre-operatively, the UPDRS III off & on respectively was 41.33/28.67 and post-operatively was 15.67/11.33 with improvement 62% /60%. The rigidity subscore was 5/3.33 pre-operatively and 1.67/1 post-operatively with average of 68% improvement. The bradykinesia subscore was 10/6 pre-operatively and 4/1.33 post-operatively with average of 72% improvement. The UPDRS II pre was 28.33/19.33 and post it became 16.33/10.67 with 43% improvement. Modified H&Y 2.83/2 pre & post-operatively (29% improvement). Postoperatively, there was a high significant statistical finding in all clinical score and subscore of parkinsonian symptoms.
CONCLUSION: The study concludes that lesioning procedure should be revisited globally using the modern techniques of targeting and controlled thermal lesion protocols guided by capsular somatotopy and intraoperative macroelectrode stimulation, that will improve the outcome dramatically. Ablative procedures proved their efficacy in controlling motor symptoms of IPD and their cost-benefit in low & middle-income nations.
- Stereotactic Ablative Procedures for Intractable Parkinson’s Disease