GeoQ in the maintenance phase

2018 ◽  
pp. 279-294
Keyword(s):  
Maintenance Phase

The PREVIEW Study

2019 ◽  
Vol 26 (1) ◽  
pp. 10-20
Author(s):  
Maija Huttunen-Lenz ◽  
Sylvia Hansen ◽  
Thomas Meinert Larsen ◽  
Pia Christensen ◽  
Mathijs Drummen ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Maintenance ◽  
Maintenance Phase ◽  
Habit Strength ◽  
Health Habits ◽  
Cross Sectional ◽  
Socio Economic Variables ◽  
Overweight Adults ◽  
Modification Intervention

Abstract. Individuals at risk of Type 2 Diabetes are advised to change health habits. This study investigated how the PREMIT behavior modification intervention and its association with socio-economic variables influenced weight maintenance and habit strength in the PREVIEW study. Overweight adults with pre-diabetes were enrolled ( n = 2,224) in a multi-center RCT including a 2-month weight-loss phase and a 34-month weight-maintenance phase for those who lost ≥ 8% body weight. Initial stages of the PREMIT covered the end of weight-loss and the beginning of weight-maintenance phase (18 weeks). Cross-sectional and longitudinal data were explored. Frequent PREMIT sessions attendance, being female, and lower habit strength for poor diet were associated with lower weight re-gain. Being older and not in employment were associated with lower habit strength for physical inactivity. The PREMIT appeared to support weight loss maintenance. Younger participants, males, and those in employment appeared to struggle more with inactivity habit change and weight maintenance.

The Negative Impact of Biological Variation in the Effect and Clearance of Warfarin on Methods for Prediction of Dose Requirements

1986 ◽  
Vol 56 (03) ◽  
pp. 371-375 ◽  
Author(s):  
Peretz Weiss ◽  
Hillel Halkin ◽  
Shlomo Almog
Keyword(s):  
Individual Variation ◽  
Negative Impact ◽  
Warfarin Dose ◽  
Empirical Therapy ◽  
Maintenance Phase ◽  
Individual Variability ◽  
Dose Prediction ◽  
Group I ◽  
Over Time ◽  
Variance Explained

SummaryWithin-individual variation over time in the clearance (Cl) and effect (PT%) of warfarin, was measured in 25 inpatients (group I) studied after standard single or individualized split loading doses and 1-3 times (n = 16) 8-16 weeks later during maintenance. Mean Cl (2.5 α 0.9 ml/min) was similar in both phases but significant changes occurred in 6/16 patients, exceeding those expected from within-individual variation alone (defined by its 95% tolerance limits -24% to +62%). Initial PT% (21 α 5) was unaffected by dosing schedule, total or free plasma warfarin, varying between patients by only 18-24%. Mean initial and maintenance dose-PT% ratios (8.2 mg/d: 21% and 4.1 mg/d: 40%) were similar but significant changes in sensitivity to warfarin occurred in 4/16 patients. In group I and 64 other outpatients on maintenance therapy, between-individual variability was 36-52% for Cl and 49-56% for effect. PT% correlated best (r = 0.56) with free and total plasma warfarin but poorly with dose (r = 0.29), with only 30% of PT% variance explained at best, due to high between patient variability.Warfarin dose prediction whether based on extrapolation from initial effects to the maintenance phase, or on iterative methods not allowing for between- or within-patient variation in warfarin clearance or effect which may occur independently over time, have not improved on empirical therapy. This, due to the elements of biological variability as well as the intricacy of the warfarin - prothrombin complex interaction not captured by any kinetic-dynamic model used for prediction to date.

scholarly journals Enhance Access to Pulmonary Rehabilitation with a Structured and Personalized Home-Based Program—reabilitAR: Protocol for Real-World Setting

2021 ◽  
Vol 18 (11) ◽  
pp. 6132
Author(s):  
Sarah Bernard ◽  
Rui Vilarinho ◽  
Inês Pinto ◽  
Rosa Cantante ◽  
Ricardo Coxo ◽  
...  
Keyword(s):  
Pulmonary Rehabilitation ◽  
Maintenance Phase ◽  
Chronic Respiratory Disease ◽  
Phone Call ◽  
Intensive Phase ◽  
Living Well ◽  
Sit To Stand ◽  
Outcomes Measures ◽  
Home Based ◽  
Patient Reported

Home-based models represent one of the solutions to respond to the poor accessibility of pulmonary rehabilitation (PR) services in patients with chronic respiratory disease (CRD). The main goal of this protocol is to present the implementation of the first nationwide home-based PR program—reabilitAR—in Portugal and the strategies to assess its benefits in patients with CRD. The program consists of 2 phases: a 12-week intensive phase and a 40-week maintenance phase (total: 52 weeks, 1 year). The intervention in both phases is composed of presential home visits and phone-call follow ups, including exercise training and the self-management educational program Living Well with COPD. Dyspnea, impact of the disease, emotional status, and level of dyspnea during activities of daily living are used as patient-reported outcomes measures. A one-minute sit-to-stand test is used as a functional outcome, and the number of steps as a measure of physical activity. To ensure safety, fall risk and the cognitive function are assessed. Data are collected at baseline, at 12 weeks, at 26 weeks and at 52 weeks. This is the first nationwide protocol on enhancing access to PR, providing appropriate responses to CRD patients’ needs through a structured and personalized home-based program in Portugal.

scholarly journals AB0393 EFFICACY OF HYDROXYCHLOROQUINE FOR LUPUS NEPHRITIS IN MAINTENANCE PHASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1496.2-1496
Author(s):  
M. Watanabe ◽  
Y. Haji ◽  
M. Kato ◽  
T. Ito ◽  
Y. Banno ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Therapeutic Option ◽  
Maintenance Phase ◽  
Base Line ◽  
Prednisolone Dose ◽  
Daily Urine ◽  
Group A ◽  
The Mean ◽  
Group B

Background:Hydroxychloroquine (HCQ) is an essential drug for systemic lupus erythematosus. But in Japan, chloroquine and HCQ remain unavailable until mid 2015 because of a series of lawsuits about its retinal toxicity in the 1970s. There is insufficient knowledge regarding renal protective effect of HCQ.Objectives:We aimed to investigate its efficacy of adding HCQ for Lupus nephritis (LN) as a maintenance-phase therapy.Methods:We conducted an observational retrospective cohort study included patients with LN (n=42) in maintenance-phase in Japan. We reviewed medical records of LN patients aged > 18 years who were initiated HCQ from May 2015 to May 2018. Maintenance phase was defined as stabilization in serum creatinine and urinary segment after induction therapy and who achieved complete or partial remission. The annual change of proteinuria was compared between patients on HCQ who have proteinuria (>0.5g/gCr) or not. Other outcome measures were disease flare, dose of steroids, renal and immunologic features.Results:A total of 42 patients were analyzed and allocated to two groups based on their amount of daily urine protein level: HCQ with proteinuria as group A (>0.5g/gCr, n=14) and HCQ without proteinuria as group B(≦0.5g/gCr, n=28). Both groups were comparable, with mean (SD) age of 36.1 (12.9) years and 37.5 (13.8), female 78.6% and 92.9% in each group, mean (SD) disease duration until HCQ of 3.5 (3.25) and 3.3 (2.9) years in group A and group B, with prednisolone dose at base line of 10.3 (7.1) mg and 7.9 (4.4) mg, respectively. The mean (SD) proteinuria at base line was 1.38 (1.11) g/gCr in group A and 0.20 (0.09) g/gCr in group B and after 12 months, proteinuria decreased in group A (-1.34 g/gCr in group A vs +0.03 g/gCr in group B; p<.001;95% CI,0.305-0.736). No relapse was experienced in group A during the study period.Conclusion:In patients with clinically stable LN but with proteinuria, hydroxychloroquine is a good therapeutic option for achievement of complete remission.Disclosure of Interests:None declared

scholarly journals Overview of lithium's use: a nationwide survey

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Xabier Pérez de Mendiola ◽  
Diego Hidalgo-Mazzei ◽  
Eduard Vieta ◽  
Ana González-Pinto
Keyword(s):  
Adverse Effects ◽  
Clinical Guidelines ◽  
Lithium Treatment ◽  
Scientific Evidence ◽  
Plasma Concentrations ◽  
Maintenance Phase ◽  
Nationwide Survey ◽  
Developed Countries ◽  
Lithium Salts ◽  
National Society

Abstract Background Lithium is considered the gold standard treatment for bipolar disorder (BD). Current clinical guidelines and scientific evidence support its use as a first-line treatment in BD. However, over the last two decades, there has been a downward tendency in lithium's use in several developed countries. Based on a nationwide survey, this study's objective is to analyze in a large sample of psychiatrists relevant issues of the use of lithium salts in BD. Methods Data were collected through an anonymous survey sent by email among 500 psychiatrists who belong to a National Society of Psychiatry (Spanish Society of Biological Psychiatry). The survey is a self-administered questionnaire consisting of 21 items on the most key aspects of lithium's use (indication, dosage, monitoring, and information for patients). Results 212 psychiatrists completed the survey. 70% of psychiatrists prescribe lithium to more than 50% of patients diagnosed with BD. Adverse effects are the main reason not to use lithium salts. Over 75% of the participants consider lithium salts the treatment of choice for the maintenance phase of BD, both in women and men. Most of the participants (> 50%) start lithium after the first affective episode, use conservative plasma concentrations (0.6–0.8 mmol/L), and generally prescribe it twice a day. 57% of psychiatrists who treat patients under 18 do not use lithium in this population. About 70% of the survey respondents use official protocols to inform and monitor patients on lithium treatment. Conclusions From the results of the present study, it can be concluded that the use of lithium in Spain is in line with the recommendations of the main international clinical guidelines and current scientific literature. The first reason not to prescribe lithium in our country is the perception of its adverse effects and not the aspects related to its practical use or its effectiveness. Considering that BD is a chronic disease with a typical onset in adolescence, the low rate of prescription of lithium salts in patients under 18 must be thoroughly studied.

scholarly journals System-based concept for a mixed reality supported maintenance phase of an industrial plant

Procedia CIRP ◽  
2020 ◽  
Vol 91 ◽  
pp. 15-20
Author(s):  
Steffen Kunnen ◽  
Dmytro Adamenko ◽  
Robin Pluhnau ◽  
André Loibl ◽  
Arun Nagarajah
Keyword(s):  
Mixed Reality ◽  
Maintenance Phase ◽  
Industrial Plant

RESTRUCTURING PROGRAMS THROUGH PROGRAM SLICING

1994 ◽  
Vol 04 (03) ◽  
pp. 349-368 ◽  
Author(s):  
HYEON SOO KIM ◽  
YONG RAE KWON ◽  
IN SANG CHUNG
Keyword(s):  
Software Maintenance ◽  
Maintenance Phase ◽  
Software Tool ◽  
Logical Structure ◽  
Program Slicing ◽  
Loosely Coupled ◽  
Function Modules ◽  
Tightly Coupled ◽  
Function Module ◽  
And Control

Software restructuring is recognized as a promising method to improve logical structure and understandability of a software system which is composed of modules with loosely-coupled elements. In this paper, we present methods of restructuring an ill-structured module at the software maintenance phase. The methods identify modules performing multiple functions and restructure such modules. For identifying the multi-function modules, the notion of the tightly-coupled module that performs a single specific function is formalized. This method utilizes information on data and control dependence, and applies program slicing to carry out the task of extracting the tightly-coupled modules from the multi-function module. The identified multi-function module is restructured into a number of functional strength modules or an informational strength module. The module strength is used as a criterion to decide how to restructure. The proposed methods can be readily automated and incorporated in a software tool.

Comparison of the therapeutic effects of epoetin zeta to epoetin alfa in the maintenance phase of renal anaemia treatment

2008 ◽  
Vol 24 (3) ◽  
pp. 625-637 ◽  
Author(s):  
Volker Wizemann ◽  
Boleslaw Rutkowski ◽  
Conrad Baldamus ◽  
Paul Scigalla ◽  
Rossen Koytchev
Keyword(s):  
Maintenance Phase ◽  
Therapeutic Effects ◽  
Epoetin Alfa ◽  
Renal Anaemia ◽  
Epoetin Zeta
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