Yeast Prions: Their Assembly into Protein Fibrils and the Role of Assembly Modulators

2012 ◽  
pp. 99-122
Keyword(s):  
Yeast Prions ◽  
Protein Fibrils

scholarly journals Probing the Role of PrP Repeats in Conformational Conversion and Amyloid Assembly of Chimeric Yeast Prions

2007 ◽  
Vol 282 (47) ◽  
pp. 34204-34212 ◽  
Author(s):  
Jijun Dong ◽  
Jesse D. Bloom ◽  
Vladimir Goncharov ◽  
Madhuri Chattopadhyay ◽  
Glenn L. Millhauser ◽  
...  
Keyword(s):  
Yeast Prions ◽  
Amyloid Assembly ◽  
Conformational Conversion

scholarly journals Macrophages in the reticuloendothelial system inhibit the propagation phase of mouse apolipoprotein A-II amyloidosis

2021 ◽  
Author(s):  
Hiroki Miyahara ◽  
Jian Dai ◽  
Ying Li ◽  
Cui Xiaoran ◽  
Hibiki Takeuchi ◽  
...  
Keyword(s):  
Disease Progression ◽  
Therapeutic Strategy ◽  
Physiological Role ◽  
Reticuloendothelial System ◽  
Innate Immune ◽  
Degenerative Diseases ◽  
Phagocytic Capacity ◽  
Apolipoprotein A ◽  
Protein Fibrils

Amyloidosis refers to a group of degenerative diseases that are characterized by the deposition of misfolded protein fibrils in various organs. Deposited amyloid may be removed by a phagocyte-dependent innate immune system; however, the precise mechanisms during disease progression remain unclear. We herein investigated the properties of macrophages that contribute to amyloid degradation and disease progression using transmissible apolipoprotein A-II amyloidosis model mice. Intravenously injected AApoAII amyloid was efficiently engulfed by reticuloendothelial macrophages in the liver and spleen and disappeared by 24 h. While cultured murine macrophages degraded AApoAII via the endosomal-lysosomal pathway, AApoAII fibrils reduced cell viability and phagocytic capacity. Furthermore, the depletion of reticuloendothelial macrophages prior to the induction of AApoAII markedly increased hepatic and splenic AApoAII deposition. These results highlight the physiological role of reticuloendothelial macrophages against inter-individual amyloid propagation and suggest the maintenance of phagocytic integrity as a therapeutic strategy to inhibit disease progression.

scholarly journals The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions

2004 ◽  
Vol 9 (8) ◽  
pp. 685-696 ◽  
Author(s):  
Yoko Kimura ◽  
Sumiko Koitabashi ◽  
Akira Kakizuka ◽  
Takashi Fujita
Keyword(s):  
Epigenetic Change ◽  
Aggregate Formation ◽  
Yeast Prions

Phase separation of a yeast prion protein promotes cellular fitness

Science ◽  
2018 ◽  
Vol 359 (6371) ◽  
pp. eaao5654 ◽  
Author(s):  
Titus M. Franzmann ◽  
Marcus Jahnel ◽  
Andrei Pozniakovsky ◽  
Julia Mahamid ◽  
Alex S. Holehouse ◽  
...  
Keyword(s):  
Phase Separation ◽  
Prion Protein ◽  
Physiological Function ◽  
Ph Sensor ◽  
Yeast Prion ◽  
Rapid Adaptation ◽  
Yeast Prions ◽  
Stress Sensors ◽  
Domain Phase

Despite the important role of prion domains in neurodegenerative disease, their physiological function has remained enigmatic. Previous work with yeast prions has defined prion domains as sequences that form self-propagating aggregates. Here, we uncovered an unexpected function of the canonical yeast prion protein Sup35. In stressed conditions, Sup35 formed protective gels via pH-regulated liquid-like phase separation followed by gelation. Phase separation was mediated by the N-terminal prion domain and regulated by the adjacent pH sensor domain. Phase separation promoted yeast cell survival by rescuing the essential Sup35 translation factor from stress-induced damage. Thus, prion-like domains represent conserved environmental stress sensors that facilitate rapid adaptation in unstable environments by modifying protein phase behavior.

Assembly of the Asparagine- and Glutamine-Rich Yeast Prions into Protein Fibrils

2008 ◽  
Vol 5 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Luc Bousset ◽  
Jimmy Savistchenko ◽  
Ronald Melki
Keyword(s):  
Yeast Prions ◽  
Protein Fibrils

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

Elaborating the role of reflection and individual differences in the study of folk-economic beliefs

2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux
Keyword(s):  
Decision Making ◽  
Individual Differences ◽  
Cognitive Processes ◽  
Evolutionary History ◽  
Behavioral Responses ◽  
History Of ◽  
Economic Beliefs

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.

The role of affect in feelings of obligation

2020 ◽  
Vol 43 ◽  
Author(s):  
Stefen Beeler-Duden ◽  
Meltem Yucel ◽  
Amrisha Vaish
Keyword(s):  
Positive Emotions ◽  
The Creation ◽  
Sense Of Obligation

Abstract Tomasello offers a compelling account of the emergence of humans’ sense of obligation. We suggest that more needs to be said about the role of affect in the creation of obligations. We also argue that positive emotions such as gratitude evolved to encourage individuals to fulfill cooperative obligations without the negative quality that Tomasello proposes is inherent in obligations.

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