Anti-Inammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome

2012 ◽  
pp. 368-381
Keyword(s):  
Metabolic Syndrome ◽  
Herbal Medicines

scholarly journals Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

2021 ◽  
pp. 54-61
Author(s):  
N. Chaika ◽  
O. Koshovyi ◽  
M. Mazen ◽  
A. Kravchenko ◽  
A. Kovalyova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Metabolic Disorders ◽  
Gallstone Disease ◽  
Herbal Medicines ◽  
Biologically Active ◽  
Hypolipidemic Activity ◽  
Large Set ◽  
Dry Extract ◽  
The Metabolic Syndrome

Topicality. The metabolic syndrome is pathogenetically interrelated metabolic disorders in the condition of a sick person. A large set of factors is involved in its occurrence. Risk factors include genetic predisposition, overeating, insulin resistance, obesity, bad habits, hypodynamics, stress and unfavorable environmental conditions. First of all, defects of the lipid and carbohydrate metabolism provoke a cascade of genetic, metabolic, hormonal, nervous, inflammatory and other reactions and disorders in cells, tissues and organs, causing the metabolic syndrome and associated diseases, such as diabetes, kidney and gallstone disease, hypertension, platelet hyperaggregation, etc. Therefore, the rational use of synthetic and herbal medicines in the complex correction of these disorders can slow down the development of the metabolic syndrome. Aim. To develop the method for obtaining a dry modified extract from bearberry, study its chemical composition, hypoglycemic and hypolipidemic activity in order to determine the prospects of its use for the correction of the metabolic syndrome. Materials and methods. The study object was a dry extract of bearberry leaves modified with cysteine. HPLC and spectrophotometry were used to analyze the extract obtained. The hypoglycemic and hypolipidemic activity of dry extracts of bearberry was studied in rats with insulin resistance. Results and discussion. The method for obtaining a dry modified extract from bearberry leaves was developed by adding cysteine. Phenologlycoside (arbutin), 2 phenolic acids (gallic and ellagic), 6 flavonoids, 8 saponins were identified in the extract, and their quantitative content was determined. Hyperoside and catechin were dominant among flavonoids, and ursolic acid, uvaol, and lupeol prevailed among saponins. The content of the main groups of phenolic compounds was determined in the extract by spectrophotometry. The introduction of the dry extract from bearberry leaves modified with cysteine has a normalizing effect on metabolic disorders on the background of a high-fructose diet; therefore, it can be a promising agent for the correction of the metabolic syndrome. Conclusions. As a result of the research conducted, a new dry extract from bearberry leaves modified with cysteine has been created. The phytochemical composition, hypoglycemic and hypolipidemic activities of the extract have been studied, indicating the prospects for its use to correct the metabolic syndrome.

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

2019 ◽  
Vol 34 (3) ◽  
pp. 526-545 ◽  
Author(s):  
Moloud Payab ◽  
Shirin Hasani‐Ranjbar ◽  
Nazila Shahbal ◽  
Mostafa Qorbani ◽  
Azadeh Aletaha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Clinical Trials ◽  
Meta Analysis ◽  
Herbal Medicines

scholarly journals Herbal Medicines for Treating Metabolic Syndrome: A Systematic Review of Randomized Controlled Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Soobin Jang ◽  
Bo-Hyoung Jang ◽  
Youme Ko ◽  
Yui Sasaki ◽  
Jeong-Su Park ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Randomized Controlled Trials ◽  
Herbal Medicines ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Alternative Medicines ◽  
Medical Theory

Objective. The aim of this systematic review is to evaluate the efficacy and safety of herbal medicines in the management of metabolic syndrome.Materials and Methods. On December 9, 2015, we searched PubMed, EMBASE, Cochrane Library, SCOPUS, AMED, CNKI, KoreaMed, KMBASE, OASIS, and J-STAGE with no restriction on language or published year. We selected randomized controlled trials that involved patients with metabolic syndrome being treated with herbal medicines as intervention. The main keywords were “Chinese herbal medicines”, “metabolic syndrome”, and “randomized controlled trials”. Herbal substances which were not based on East Asian medical theory, combination therapy with western medicines, and concurrent diseases other than metabolic syndrome were excluded. The risk of bias was assessed by Cochrane’s “Risk of Bias” tool. The protocol or review was registered in PROSPERO (an international prospective register of systematic reviews) (CRD42014006842).Results. From 1,098 articles, 12 RCTs were included in this review: five trials studied herbal medicines versus a placebo or no treatment, and seven trials studied herbal medicines versus western medicines. Herbal medicines were effective on decreasing waist circumference, blood glucose, blood lipids, and blood pressure.Conclusion. This study suggests the possibility that herbal medicines can be complementary and alternative medicines for metabolic syndrome.

scholarly journals Antioxidant phytochemicals against type 2 diabetes

2008 ◽  
Vol 99 (E-S1) ◽  
pp. ES109-ES117 ◽  
Author(s):  
Aldona Dembinska-Kiec ◽  
Otto Mykkänen ◽  
Beata Kiec-Wilk ◽  
Hannu Mykkänen
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Chronic Diseases ◽  
Glucose Homeostasis ◽  
Diabetes Complications ◽  
Herbal Medicines ◽  
Considerable Part ◽  
The Metabolic Syndrome ◽  
Dietary Phytochemicals

Dietary phytochemicals, of which polyphenols form a considerable part, may affect the risk of obesity-associated chronic diseases such as type 2 diabetes. This article presents an overview on how phytochemicals, especially polyphenols in fruits, vegetables, berries, beverages and herbal medicines, may modify imbalanced lipid and glucose homeostasis thereby reducing the risk of the metabolic syndrome and type 2 diabetes complications.

scholarly journals The Trend of Scientific Productions on the Use of Herbal Medicines in Metabolic Disorders in the Middle East Countries

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ozra Tabatabaei-Malazy ◽  
Shekoufeh Nikfar ◽  
Mohammad Abdollahi ◽  
Bagher Larijani
Keyword(s):  
Metabolic Syndrome ◽  
Middle East ◽  
Herbal Medicine ◽  
Time Trend ◽  
Metabolic Disorders ◽  
Low Cost ◽  
Herbal Medicines ◽  
Subject Area ◽  
Publication Number ◽  
Middle East Countries

Context: Prevalence of metabolic disorders, type 2 diabetes mellitus (T2DM), dyslipidemia, obesity, metabolic syndrome (MetS), and osteoporosis has been increased. Herbal medicine is an accessible, safe, and low-cost option in managing and caring for metabolic disorders. We conducted a bibliometric analysis of global scientific productions in herbal medications and metabolic disorders in the Middle East countries. Study Selection: Our search terms were “diabetes”, “dyslipidemia”, “obesity”, “osteoporosis”, “metabolic syndrome”, “herb”, and “herbal medicine” in Middle East countries through the Scopus database until January 2020. We analyzed the data regarding publication year, main journal, geographical distribution, document type, subject area, co-authorship network, the h-index of citations by Scopus analysis tools, Visualizing Scientific Landscapes (VOSviewer) version 1.6.4, and SPSS version 15. Results: Among 6408 global publications, most of the papers (> 85%) were original articles, and mostly (44.26%) were about dyslipidemia. A significant time-trend was shown in the number of documents (P < 0.001), mostly in 2019. Medicine and pharmacology were subject areas in > 80% of papers. The top country in the global publication number was Iran. The highest cited papers in dyslipidemia, obesity and osteoporosis were original articles from Turkey and Egypt, but in T2DM and MetS the highest cited paper was a review article from Iran. The top sources were “Phytotherapy Research” and “the Journal of Ethnopharmacology”. The top institutes were from Egypt, Iran, and Saudi Arabia and the principal author in the co-authorship network assessment was from Iran. Conclusions: The time-trend growth in producing scholarly papers in the studied disorders is appreciated, but more evidence-based articles are still needed.

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