Conscious and unconscious music from the brain: Design and development of a tool translating brainwaves into music using a BCI device

2012 ◽  
pp. 685-694
Keyword(s):  
Design And Development ◽  
The Brain

scholarly journals Design and Development of the Brain Training System for the Digital “Maintain Your Brain” Dementia Prevention Trial

JMIR Aging ◽  
10.2196/13135 ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. e13135 ◽  
Author(s):  
Courtney Campbell Walton ◽  
Amit Lampit ◽  
Christos Boulamatsis ◽  
Harry Hallock ◽  
Polly Barr ◽  
...  
Keyword(s):  
Training System ◽  
Prevention Trial ◽  
Brain Training ◽  
Design And Development ◽  
Dementia Prevention ◽  
The Brain

scholarly journals Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 265
Author(s):  
Shivkanya Fuloria ◽  
Muhamad Azrul Amir Yusri ◽  
Mahendran Sekar ◽  
Siew Hua Gan ◽  
Nur Najihah Izzati Mat Rani ◽  
...  
Keyword(s):  
Animal Models ◽  
Cognitive Performance ◽  
Memory Impairment ◽  
Preclinical Studies ◽  
Design And Development ◽  
Structural Modifications ◽  
Naturally Occurring ◽  
Challenges And Opportunities ◽  
Derivatives Of ◽  
The Brain

Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the effects of genistein in the brain, including its pharmacokinetics, bioavailability, behavioral effects, and some of the potential mechanisms of action on memory in several animal models. The results of the preclinical studies highly suggested that genistein is highly effective in enhancing the cognitive performance of the MI animal models, specifically in the memory domain, including spatial, recognition, retention, and reference memories, through its ability to reduce oxidative stress and attenuate neuroinflammation. This review also highlighted challenges and opportunities to improve the drug delivery of genistein for treating MI. Along with that, the possible structural modifications and derivatives of genistein to improve its physicochemical and drug-likeness properties are also discussed. The outcomes of the review proved that genistein can enhance the cognitive performance and ameliorate MI in different preclinical studies, thus indicating its potential as a natural lead for the design and development of a novel neuroprotective drug.

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