Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder

2005 ◽  
pp. 667-686
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Animal Model ◽  
Attention Deficit ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hyperactivity Disorder

scholarly journals Differences in serum steroid hormones concentrations in Spontaneously Hypertensive Rats (SHR) – an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD)

2019 ◽  
pp. 25-36 ◽  
Author(s):  
A. Kozłowska ◽  
P. Wojtacha ◽  
M. Równiak ◽  
M. Kolenkiewicz ◽  
M.-L. Tsai
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Animal Model ◽  
Steroid Hormones ◽  
Attention Deficit ◽  
Spontaneously Hypertensive Rats ◽  
Third Ventricle ◽  
Cerebral Aqueduct ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hyperactivity Disorder

Spontaneously hypertensive rats are the most common animal model used to study attention deficit hyperactivity disorder (ADHD). The present study investigated the levels of steroid hormones in the bloodstream of hypertensive rats and its normotensive control strain, Wistar-Kyoto rats, to check if there are any hormonal differences between both strains at the onset of ADHD. Plasma samples were collected from young (5-week-old) and mature (10-week-old) male hypertensive and normotensive rats to determine the serum level of testosterone, 17beta-estradiol, free estriol, progesterone, corticosterone and cortisol using ELISA kits. The results showed statistically significant increases in serum levels of testosterone and free estriol in 10-week-old hypertensive and normotensive rats when compared to 5-week-old animals. Moreover, the concentrations of progesterone, corticosterone and cortisol were significantly elevated in 10-week-old hypertensive rats when compared to 5-week-old animals of both strains as well as 10-week-old normotensive rats. Hormonal differences observed between 10-week-old hypertensive and normotensive rats were also accompanied by differences in the volumes of lateral ventricles as well as the third ventricle and cerebral aqueduct. In conclusion, elevated contents of progesterone, corticosterone and cortisol in hypertensive rats may be associated not only with ADHD but also with developing hypertension. This question needs further study.

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