How Substrate Properties Control Cell Adhesion

2011 ◽  
pp. 3-18 ◽  
Author(s):  
Alain Carré ◽  
Valérie Lacarrière
Keyword(s):  
Cell Adhesion ◽  
Control Cell ◽  
Substrate Properties

Development of Polymer/Nanodiamond Composite Coatings to Control Cell Adhesion, Growth, and Functions

2015 ◽  
pp. 1-26 ◽  
Author(s):  
Milena Keremidarska ◽  
Kamelia Hristova ◽  
Todor Hikov ◽  
Ekaterina Radeva ◽  
Dimitar Mitev ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Composite Coatings ◽  
Control Cell

scholarly journals Distinct impacts of substrate elasticity and ligand affinity on traction force evolution

Soft Matter ◽  
2016 ◽  
Vol 12 (1) ◽  
pp. 272-280 ◽  
Author(s):  
Christina Müller ◽  
Tilo Pompe
Keyword(s):  
Cell Adhesion ◽  
Traction Force ◽  
Initial Cell ◽  
Ligand Affinity ◽  
Substrate Properties ◽  
Substrate Elasticity ◽  
Late Stages ◽  
Initial Cell Adhesion ◽  
Adhesion Process

Elastic and viscous substrate properties distinctively determine traction force evolution in early and late stages of the initial cell adhesion process.

scholarly journals Micropatterned Multicolor Dynamically Adhesive Substrates to Control Cell Adhesion and Multicellular Organization

Langmuir ◽  
2014 ◽  
Vol 30 (5) ◽  
pp. 1327-1335 ◽  
Author(s):  
Natalia M. Rodriguez ◽  
Ravi A. Desai ◽  
Britta Trappmann ◽  
Brendon M. Baker ◽  
Christopher S. Chen
Keyword(s):  
Cell Adhesion ◽  
Control Cell

scholarly journals Interconnected Microchannels in Hydrogels to Control Cell Adhesion and Mechanotransduction

2018 ◽  
Vol 114 (3) ◽  
pp. 192a
Author(s):  
Mohammadreza Taale ◽  
Christine Arndt ◽  
Christine Selhuber-Unkel
Keyword(s):  
Cell Adhesion ◽  
Control Cell

Molding Micropatterns of Elasticity on PEG-Based Hydrogels to Control Cell Adhesion and Migration

2011 ◽  
Vol 13 (10) ◽  
pp. B395-B404 ◽  
Author(s):  
Mar Diez ◽  
Vera A. Schulte ◽  
Filippo Stefanoni ◽  
Carlo F. Natale ◽  
Francesco Mollica ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Control Cell ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals Light-Modulated Cell Adhesion to Control Cell and Tissue Morphogenesis

2014 ◽  
Vol 106 (2) ◽  
pp. 789a
Author(s):  
Jeffrey van Haren ◽  
Torsten Wittmann
Keyword(s):  
Cell Adhesion ◽  
Control Cell ◽  
Tissue Morphogenesis

scholarly journals Mechano-redox control of integrin de-adhesion

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Freda Passam ◽  
Joyce Chiu ◽  
Lining Ju ◽  
Aster Pijning ◽  
Zeenat Jahan ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ligand Binding ◽  
Protein Interactions ◽  
Metal Binding ◽  
Control Function ◽  
Control Cell ◽  
Mechanical Force ◽  
Cell Surface Receptor ◽  
Adhesive Properties ◽  
Αiibβ3 Integrin

How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, ERp5, have revealed that it mediates release of fibrinogen from activated platelet αIIbβ3 integrin. Protein chemical studies show that ligand binding to extended αIIbβ3 integrin renders the βI-domain Cys177-Cys184 disulfide bond cleavable by ERp5. Fluid shear and force spectroscopy assays indicate that disulfide cleavage is enhanced by mechanical force. Cell adhesion assays and molecular dynamics simulations demonstrate that cleavage of the disulfide induces long-range allosteric effects within the βI-domain, mainly affecting the metal-binding sites, that results in release of fibrinogen. This coupling of ligand binding, force and redox events to control cell adhesion may be employed to regulate other protein-protein interactions.

Sign in / Sign up

Export Citation Format

Share Document