Applications of Micro- and Nano-technology to Study Cell Adhesion to Material Surfaces

2011 ◽  
pp. 141-154
Author(s):  
Franz Bruckert ◽  
Marianne Weidenhaupt
Keyword(s):  
Cell Adhesion ◽  
Nano Technology ◽  
Material Surfaces

scholarly journals Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules

2021 ◽  
Author(s):  
Kern Hast ◽  
Zhaoju Jia ◽  
Melih Baci ◽  
Tushar Aggarwal ◽  
Enver C Izgu
Keyword(s):  
Cell Adhesion ◽  
Surface Functionalization ◽  
Medical Devices ◽  
Cyclic Peptide ◽  
Bioactive Molecules ◽  
Metal Catalyst ◽  
Medical Applications ◽  
Biological Applications ◽  
Cytoskeletal Organization ◽  
Material Surfaces

The ability to control and modify the bioactivity of surfaces is pivotal to the success of many medical devices. A biocompatible and bioorthogonal method to functionalize surfaces with a wide variety of bioactive molecules is an important tool for enabling innovative biotechnology and medical applications. We report herein a novel, catecholamine-based surface functionalization method that is chemoselective and free of a metal catalyst. This method utilizes the ligation between a coating formed from the tyrosinase-catalyzed polymerization of a tetrazine-containing catecholamine and one or more strained alkene-containing molecules of interest. The process is achieved under conditions ideal for biological applications. Using this method, we graft surfaces with a variety of active molecules, including a small molecule fluorophore, enzymes, and a cyclic peptide with the RGD motif, and demonstrate the maintenance of their activity on the surface. Additionally, we establish the cytocompatibility of grafted ECM-mimicking surfaces with fibroblasts and show improved cell adhesion and cytoskeletal organization.

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell
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