Strategies for Functionalisation of Magnetic Nanoparticles for Biological Targets

Magnetorelaxometry of magnetic nanoparticles with fluxgate magnetometers for the analysis of biological targets

Journal of Magnetism and Magnetic Materials ◽

10.1016/j.jmmm.2005.02.045 ◽

2005 ◽

Vol 293 (1) ◽

pp. 690-695 ◽

Cited By ~ 59

Author(s):

Frank Ludwig ◽

Erik Heim ◽

Sascha Mäuselein ◽

Dietmar Eberbeck ◽

Meinhard Schilling

Keyword(s):

Magnetic Nanoparticles ◽

Biological Targets

Download Full-text

Nanoarmoring of Enzymes with Carbon Nanotubes and Magnetic Nanoparticles

10.1016/s0076-6879(20)x0002-4 ◽

2020 ◽

Keyword(s):

Carbon Nanotubes ◽

Magnetic Nanoparticles

Download Full-text

Thermal Conductivity of Nanofluid with Magnetic Nanoparticles

PIERS Online ◽

10.2529/piers080904124024 ◽

2009 ◽

Vol 5 (3) ◽

pp. 231-234 ◽

Cited By ~ 12

Author(s):

Tsung-Han Tsai ◽

Long-Sheng Kuo ◽

Ping-Hei Chen ◽

Chin-Ting Yang

Keyword(s):

Thermal Conductivity ◽

Magnetic Nanoparticles

Download Full-text

Ferromagnetic Resonance Biosensor for Homogeneous and Volumetric Detection of DNA

10.26434/chemrxiv.5662315.v1 ◽

2017 ◽

Author(s):

Bo Tian ◽

Peter Svedlindh ◽

Mattias Strömberg ◽

Erik Wetterskog

Keyword(s):

Magnetic Nanoparticles ◽

Ferromagnetic Resonance ◽

Limit Of Detection ◽

Point Of Care ◽

Rolling Circle Amplification ◽

Resonance Field ◽

Isothermal Amplification ◽

Detection Sensitivity ◽

Serum Samples ◽

Rolling Circle

In this work, we demonstrate for the first time, a ferromagnetic resonance (FMR) based homogeneous and volumetric biosensor for magnetic label detection. Two different isothermal amplification methods, i.e., rolling circle amplification (RCA) and loop-mediated isothermal amplification (LAMP) are adopted and combined with a standard electron paramagnetic resonance (EPR) spectrometer for FMR biosensing. For RCA-based FMR biosensor, binding of RCA products of a synthetic Vibrio cholerae target DNA sequence gives rise to the formation of aggregates of magnetic nanoparticles. Immobilization of nanoparticles within the aggregates leads to a decrease of the net anisotropy of the system and a concomitant increase of the resonance field. A limit of detection of 1 pM is obtained with an average coefficient of variation of 0.16%, which is superior to the performance of other reported RCA-based magnetic biosensors. For LAMP-based sensing, a synthetic Zika virus target oligonucleotide is amplified and detected in 20% serum samples. Immobilization of magnetic nanoparticles is induced by their co-precipitation with Mg2P2O7 (a by-product of LAMP) and provides a detection sensitivity of 100 aM. The fast measurement, high sensitivity and miniaturization potential of the proposed FMR biosensing technology makes it a promising candidate for designing future point-of-care devices.

Download Full-text