Magnetic Particle Imaging for Angiography, Stem Cell Tracking, Cancer Imaging and Inflammation Imaging

2012 ◽  
pp. 523-540
Author(s):  
Patrick Goodwill ◽  
Kannan Krishnan ◽  
Steven Conolly
Keyword(s):  
Stem Cell ◽  
Cell Tracking ◽  
Magnetic Particle ◽  
Cancer Imaging ◽  
Stem Cell Tracking ◽  
Magnetic Particle Imaging ◽  
Inflammation Imaging ◽  
Particle Imaging

Increasing the sensitivity for stem cell monitoring in system-function based magnetic particle imaging

2016 ◽  
Vol 61 (9) ◽  
pp. 3279-3290 ◽  
Author(s):  
Kolja Them ◽  
J Salamon ◽  
P Szwargulski ◽  
S Sequeira ◽  
M G Kaul ◽  
...  
Keyword(s):  
Stem Cell ◽  
Magnetic Particle ◽  
System Function ◽  
Magnetic Particle Imaging ◽  
Cell Monitoring ◽  
Particle Imaging

scholarly journals Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging

Nano Letters ◽  
2017 ◽  
Vol 18 (1) ◽  
pp. 182-189 ◽  
Author(s):  
Guosheng Song ◽  
Min Chen ◽  
Yanrong Zhang ◽  
Liyang Cui ◽  
Haibo Qu ◽  
...  
Keyword(s):  
Iron Oxides ◽  
Cell Tracking ◽  
Magnetic Particle ◽  
Semiconducting Polymer ◽  
Polymer Nanoparticle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals Development of Magnetic Particle Imaging (MPI) for Cell Tracking and Detection

2020 ◽  
Author(s):  
Kierstin P Melo ◽  
Ashley V Makela ◽  
Natasha N Knier ◽  
Amanda M Hamilton ◽  
Paula J Foster
Keyword(s):  
Iron Content ◽  
Cell Tracking ◽  
Magnetic Particle ◽  
Ex Vivo ◽  
Imaging Modality ◽  
Superparamagnetic Iron Oxide ◽  
Cell Injection ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

AbstractIntroductionMagnetic particle imaging (MPI) is a new imaging modality that sensitively and specifically detects superparamagnetic iron oxide nanoparticles (SPIONs) within a sample. SPION-based MRI cell tracking has very high sensitivity, but low specificity and quantification of iron labeled cells is difficult. MPI cell tracking could overcome these challenges.MethodsMDM-AB-231BR cells labeled with MPIO, mice were intracardially injected with either 2.5 × 105 or 5.0 × 105 cells. MRI was performed in vivo the same day at 3T using a bSSFP sequence. After mice were imaged ex vivo with MPI. In a second experiment Mice received an intracardiac injection of either 2.5 × 10 5 or 5 × 10 4 MPIO-labeled 231BR cells. In a third experiment, mice were injected with 5 × 10 4 4T1BR cells, labelled with either MPIO or the SPION Vivotrax. MRI and MPI was performed in vivo.ResultsSignal from MPI and signal voids from MRI both showed more iron content in mice receiving an injection of 5.0 × 105 cells than the 2.5 × 105 injection. In the second experiment, Day 0 MRI showed signal voids and MPI signal was detected in all mouse brains. The MPI signal and iron content measured in the brains of mice that were injected with 2.5 × 10 5 cells were approximately four times greater than in brains injected with 5 × 10 4 cells. In the third experiment, in vivo MRI was able to detect signal voids in the brains of mice injected with Vivotrax and MPIO, although voids were fainter in Vivotrax labeled cells. In vivo MPI signal was only detectable in mice injected with MPIO-labeled cells.ConclusionThis is the first example of the use of MPIO for cell tracking with MPI. With an intracardiac cell injection, approximately 15% of the injected cells are expected to arrest in the brain vasculature. For our lowest cell injection of 5.0 × 104 cells this is ∼10000 cells.

scholarly journals Magnetic particle imaging for radiation-free, sensitive and high-contrast vascular imaging and cell tracking

2018 ◽  
Vol 45 ◽  
pp. 131-138 ◽  
Author(s):  
Xinyi Y Zhou ◽  
Zhi Wei Tay ◽  
Prashant Chandrasekharan ◽  
Elaine Y Yu ◽  
Daniel W Hensley ◽  
...  
Keyword(s):  
Cell Tracking ◽  
Magnetic Particle ◽  
Vascular Imaging ◽  
High Contrast ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals The Applications of Magnetic Particle Imaging: From Cell to Body

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 800
Author(s):  
Xiao Han ◽  
Yang Li ◽  
Weifeng Liu ◽  
Xiaojun Chen ◽  
Zeyu Song ◽  
...  
Keyword(s):  
Cell Tracking ◽  
Magnetic Particle ◽  
Tumor Imaging ◽  
Positive Contrast ◽  
Blood Pool ◽  
Superparamagnetic Nanoparticles ◽  
Surrounding Tissue ◽  
Background Signal ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

Magnetic particle imaging (MPI) is a cutting-edge imaging technique that is attracting increasing attention. This novel technique collects signals from superparamagnetic nanoparticles as its imaging tracer. It has characteristics such as linear quantitativity, positive contrast, unlimited penetration, no radiation, and no background signal from surrounding tissue. These characteristics enable various medical applications. In this paper, we first introduce the development and imaging principles of MPI. Then, we discuss the current major applications of MPI by dividing them into four categories: cell tracking, blood pool imaging, tumor imaging, and visualized magnetic hyperthermia. Even though research on MPI is still in its infancy, we hope this discussion will promote interest in the applications of MPI and encourage the design of tracers tailored for MPI.

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