Bioactive Constituents of Medicinal Plants

2012 ◽  
pp. 200-225
Keyword(s):  
Medicinal Plants ◽  
Bioactive Constituents

scholarly journals CYTOTOXICITY ACTIVITY OF SOME INDIAN MEDICINAL PLANTS

2016 ◽  
Vol 8 (4) ◽  
pp. 86
Author(s):  
Dora Babu Neerugatti ◽  
Ganga Rao Battu ◽  
Raviteja Bandla
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Human Cancer ◽  
Bioactive Constituents ◽  
Cytotoxicity Activity ◽  
Human Cancer Cell Lines ◽  
Methanolic Extracts ◽  
Dose Dependent ◽  
New Anticancer Drugs ◽  
Indian Medicinal Plants

Objective: The current study is carried out to evaluate cytotoxicity activity of the methanolic extracts of some medicinal plants (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz).Methods: Cytotoxicity activity was evaluated on human cancer cell lines such as lung cancer (A549) and skin cancer (A431) using MTT assay method.Results: The selected plant extracts showed the dose-dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for tested plants extracts. The cytotoxicity of the extracts was increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines.Conclusion: The results of the present study supported the folkloric usage of the studied plants and confirmed that the plant's extracts have the bioactive constituents with cytotoxic properties and their isolation can be useful for developing new anticancer drugs.

scholarly journals Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity

BMC Chemistry ◽  
2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Tsvetinka Grozdanova ◽  
Boryana Trusheva ◽  
Kalina Alipieva ◽  
Milena Popova ◽  
Lyudmila Dimitrova ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Medicinal Plants ◽  
Total Phenolics ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Bioactive Constituents ◽  
Primary Metabolites ◽  
E Coli ◽  
Natural Deep Eutectic Solvents ◽  
Toxic Organic Solvents

AbstractNatural deep eutectic solvents (NADES) are a new alternative to toxic organic solvents. Their constituents are primary metabolites, non-toxic, biocompatible and sustainable. In this study four selected NADES were applied for the extraction of two medicinal plants: Sideritis scardica, and Plantago major as an alternative to water-alcohol mixtures, and the antimicrobial and genotoxic potential of the extracts were studied. The extraction efficiency was evaluated by measuring the extracted total phenolics, and total flavonoids. Best extraction results for total phenolics for the studied plants were obtained with choline chloride-glucose 5:2 plus 30% water; but surprisingly these extracts were inactive against all tested microorganisms. Extracts with citric acid-1,2-propanediol 1:4 and choline chloride-glycerol 1:2 showed good activity against S. pyogenes, E. coli, S. aureus, and C. albicans. Low genotoxicity and cytotoxicity were observed for all four NADES and the extracts with antimicrobial activity. Our results confirm the potential of NADESs for extraction of bioactive constituents of medicinal plants and further suggest that NADES can improve the effects of bioactive extracts. Further studies are needed to clarify the influence of the studied NADES on the bioactivity of dissolved substances, and the possibility to use such extracts in the pharmaceutical and food industry.

scholarly journals A Review on Ethnomedicinal Plants of Nimar Area in Madhya Pradesh

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Pragati Jaiswal ◽  
Bharti Jain
Keyword(s):  
Medicinal Plants ◽  
Herbal Medicines ◽  
Central India ◽  
Madhya Pradesh ◽  
Western Region ◽  
Herbal Drugs ◽  
Bioactive Constituents ◽  
Therapeutic Properties ◽  
Day By Day ◽  
Different Parts

Medicinal plants are a boon for disease. Nature has provided a rich botanical wealth with diverse plantation in different parts of India. Medicinal plants are useful for human ailments because of the presence of bioactive constituents or phytochemicals which are secondary metabolites such as alkaloids, saponin, glycosides, lactones, steroids etc. Due to the rapid extension of side effects of allopathic medicines, Herbal medicines are becoming popular day by day as Herbal drugs are safe, cheaper and easily available with therapeutic properties. In Nimar region of Madhya Pradesh, lots of common medicinal plants are available that are used by Nimari people and tribes as remedy to cure diseases. Nimar is the south western region of Madhya Pradesh state in west central India. The present paper provides information on 52 medicinal plants of Nimar area.

Screening of six Ayurvedic medicinal plants for anti-obesity potential: An investigation on bioactive constituents from Oroxylum indicum (L.) Kurz bark

2017 ◽  
Vol 197 ◽  
pp. 138-146 ◽  
Author(s):  
Priyanka Mangal ◽  
Pragyanshu Khare ◽  
Sneha Jagtap ◽  
Mahendra Bishnoi ◽  
Kanthi Kiran Kondepudi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Bioactive Constituents ◽  
Oroxylum Indicum

Screening of some medicinal plants for anticariogenic activity: An investigation on bioactive constituents from Jatropha gossypifolia (L.) root

2017 ◽  
Vol 10 ◽  
pp. 161-166 ◽  
Author(s):  
S. Mutheeswaran ◽  
P. Saravana Kumar ◽  
P. Yuvaraj ◽  
V. Duraipandiyan ◽  
Naif Abdullah Al-Dhabi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Bioactive Constituents ◽  
Jatropha Gossypifolia

scholarly journals Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sibhghatulla Shaikh ◽  
Khurshid Ahmad ◽  
Syed Sayeed Ahmad ◽  
Eun Ju Lee ◽  
Jeong Ho Lim ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Herbal Medicines ◽  
Therapeutic Management ◽  
Bioactive Constituents ◽  
Active Components ◽  
Beneficial Effects ◽  
Therapeutic Benefits ◽  
Division Process ◽  
Autophagic Degradation ◽  
Cytoplasmic Content

Autophagy is an essential cellular process that involves the transport of cytoplasmic content in double-membraned vesicles to lysosomes for degradation. Neurons do not undergo cytokinesis, and thus, the cell division process cannot reduce levels of unnecessary proteins. The primary cause of neurodegenerative disorders (NDs) is the abnormal deposition of proteins inside neuronal cells, and this could be averted by autophagic degradation. Thus, autophagy is an important consideration when considering means of developing treatments for NDs. Various pharmacological studies have reported that the active components in herbal medicines exhibit therapeutic benefits in NDs, for example, by inhibiting cholinesterase activity and modulating amyloid beta levels, and α-synuclein metabolism. A variety of bioactive constituents from medicinal plants are viewed as promising autophagy controllers and are revealed to recover the NDs by targeting the autophagic pathway. In the present review, we discuss the role of autophagy in the therapeutic management of several NDs. The molecular process responsible for autophagy and its importance in various NDs and the beneficial effects of medicinal plants in NDs by targeting autophagy are also discussed.

scholarly journals Traditional knowledge, medicinal plants, bioactive constituents, and prospecting technology: potential control of fungi

2021 ◽  
Vol 10 (13) ◽  
pp. e355101321410
Author(s):  
Antonio Fávero de Carvalho ◽  
Allívia Rouse Carregosa Rabbani ◽  
Sheila Valéria Álvares-Carvalho ◽  
Renata Silva-Mann
Keyword(s):  
Medicinal Plants ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
New Drugs ◽  
Human Beings ◽  
Bioactive Constituents ◽  
Active Components ◽  
Potential Control ◽  
The North ◽  
New Compounds

The use of plants with medicinal properties for fungi control has led to a continuous exploration of new compounds that could contribute towards promising studies in the development of new drugs and the knowledge of how this control is performed on microorganisms. The objective of this review has been to report on the potential use of medicinal plants to control the pathogenic fungi of a host of plants and animals, which can contribute to the achievement of new formulations for botanical fungicides. Many authors have demonstrated antifungal and general antimicrobial activities for Brazilian flora species through well-established methods, such as by microdilution, agar diffusion, and disk diffusion, while determining a minimum inhibitory concentration (MIC), minimum fungicidal concentrations (MFC), and the inhibition potential of essential oils, extracts and fractions. In this review, 68 species were cited for occurring in Brazil, with 25 being in the north-northeastern part of the country. Thus, most studies about the antimicrobial activities of medicinal plants bring an ‘initial understanding’ of their potential, particularly of some species, genera, and even families. Nevertheless, more data that is exceedingly specific is mandatory by focusing on new and more accurate approaches, such as the action mechanisms, toxicity, the active components, and the verification of the existence of synergic effects. These criteria would be the minimum required to develop new natural products as alternative treatments for the various infectious pathologies that affect plants, animals, and human beings.

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