Prevention and Mitigation of Late Adverse Effects of High Radiation Doses

2012 ◽  
pp. 186-217
Keyword(s):  
Adverse Effects ◽  
Radiation Doses ◽  
High Radiation ◽  
Late Adverse Effects

Hepatic late adverse effects after treatment for childhood cancer

2010 ◽  
Author(s):  
Renée L Mulder ◽  
Elvira C van Dalen ◽  
Dorine Bresters ◽  
Yoon Loke ◽  
Edith Leclercq ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Childhood Cancer ◽  
Late Adverse Effects

scholarly journals Radiation-Induced Noncancer Risks in Interventional Cardiology: Optimisation of Procedures and Staff and Patient Dose Reduction

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Zhonghua Sun ◽  
Aini AbAziz ◽  
Ahmad Khairuddin Md Yusof
Keyword(s):  
Potential Risk ◽  
Medical Staff ◽  
Interventional Procedure ◽  
Cardiovascular Effects ◽  
Interventional Cardiology ◽  
Evidence Based ◽  
Radiation Doses ◽  
High Radiation ◽  
Radiation Induced ◽  
Patient Dose Reduction

Concerns about ionizing radiation during interventional cardiology have been increased in recent years as a result of rapid growth in interventional procedure volumes and the high radiation doses associated with some procedures. Noncancer radiation risks to cardiologists and medical staff in terms of radiation-induced cataracts and skin injuries for patients appear clear potential consequences of interventional cardiology procedures, while radiation-induced potential risk of developing cardiovascular effects remains less clear. This paper provides an overview of the evidence-based reviews of concerns about noncancer risks of radiation exposure in interventional cardiology. Strategies commonly undertaken to reduce radiation doses to both medical staff and patients during interventional cardiology procedures are discussed; optimisation of interventional cardiology procedures is highlighted.

scholarly journals The photocarcinogenicity of anthracence: photochemical binding to deoxyribonucleic acid in tissue culture

1975 ◽  
Vol 149 (1) ◽  
pp. 289-291 ◽  
Author(s):  
G M Blackburn ◽  
P E Taussig
Keyword(s):  
Molecular Weight ◽  
Tissue Culture ◽  
High Molecular Weight ◽  
Deoxyribonucleic Acid ◽  
Radiation Doses ◽  
Mammalian Tissue ◽  
Hydrocarbon Molecule ◽  
High Radiation ◽  
High Molecular Weight Dna ◽  
Low Radiation Doses

Anthracene becomes covalently bound to high-molecular-weight DNA in mammalian tissue culture as a result of irradiation at 365 nm after the incubation of cells with the hydrocarbon. At high radiation doses, the extent of binding exceeds one hydrocarbon molecule per 103 bases, and is lethal. At low radiation doses, much decreased binding is observed, but a majority of cells remain viable and can be recultured.

scholarly journals Rehabilitation targeted late adverse effects after radiotherapy for cervical cancer – Different gains in different settings

2017 ◽  
Vol 6 (2) ◽  
pp. 9 ◽  
Author(s):  
Karin B. Dieperink ◽  
Lene Sigaard ◽  
Helle Mona Larsen ◽  
Tina Broby Mikkelsen
Keyword(s):  
Cervical Cancer ◽  
Adverse Effects ◽  
Cancer Survivors ◽  
Social Life ◽  
Psychosocial Interventions ◽  
Sexual Problems ◽  
Residential Setting ◽  
Sexual Rehabilitation ◽  
Late Adverse Effects ◽  
Residential Rehabilitation

Many cervical cancer survivors experience late adverse effects, and rehabilitation may alleviate symptoms. This study describes participants’ experiences with late adverse effects in daily living and with experiences of perceived rehabilitation in hospital, municipal, and a residential setting. Twenty-one cervical cancer survivors aged 40-72 years, curatively treated with concomitant radio-chemotherapy, with moderate/severe incontinence and sexual problems, participated in a 5-day residential rehabilitation intervention. Three focus group interviews were conducted and analyzed. Late adverse effects like incontinence, sexual problems, tinnitus and pain severely restricted everyday life. The participants described rehabilitation in hospital settings as fragmented, but several of the participants benefitted from the physical rehabilitation in municipal settings; however, no participants were offered sexual rehabilitation. In the residential setting, they gained a sense of connectedness and confidence in association with peers. More time to reflect and the anonymity gave opportunity to work with sensitive issues e.g. sexuality. Increased knowledge about late adverse effects and tools to alleviate these made the participants prepared to regain command of their lives. In conclusion, incontinence and tinnitus had especially impact on social life and every day activities. The participants benefitted especially from rehabilitation in two settings (municipal and residential). Intensively psychosocial interventions allowed participants to work with underlying problems. Women with sexual and/or incontinence problems favored the residential rehabilitation due to anonymity.

scholarly journals Late side-effects of valproate and lamotrigine

2007 ◽  
Vol 13 (4) ◽  
pp. 187-189 ◽  
Author(s):  
Bernardo Moreira ◽  
Sigride Thomé-Souza ◽  
Kette Valente
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Seizure Control ◽  
Diagnostic Investigation ◽  
Late Side Effects ◽  
Adolescents And Adults ◽  
Late Adverse Effects ◽  
Generalized Epilepsy ◽  
Late Side ◽  
Chronic Use

Lamotrigine (LTG) is a generally well-tolerated antiepileptic drug with broad-spectrum efficacy in several forms of partial and generalized epilepsy. Adverse effects of lamotrigine are usually associated with introduction and titration. This risk increases in children and in the co-medication with valproate. Herein, we report four patients with late adverse-effects, under the co-medication valproate and LTG, not related to drug introduction or titration. This study demonstrates that late side-effects without apparent etiology in children, adolescents and adults in chronic use of LTG, especially when associated to VPA, led to a diagnostic investigation, sometimes invasive. It must be emphasized that, due to the excellent seizure control, the authors opted for drug decrease instead of drug withdrawal, as previously done. Studies on late adverse effects are scarce, but physicians must be aware of these risks.

Lentivirally-delivered superoxide dismutase 2 gene therapy in free flaps protects against the late adverse effects of radiotherapy

2014 ◽  
Vol 67 (11) ◽  
pp. 1604
Author(s):  
Aadil A. Khan ◽  
Martin McLaughlin ◽  
Joan Kyula ◽  
Michelle Wilkinson ◽  
Paul A. Harris ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Superoxide Dismutase ◽  
Adverse Effects ◽  
Free Flaps ◽  
Late Adverse Effects ◽  
Superoxide Dismutase 2

Management of late adverse effects after chemoradiation for anal cancer

2021 ◽  
pp. 1-14
Author(s):  
Susanne Haas ◽  
Anette H. Mikkelsen ◽  
Camilla Kronborg ◽  
Birthe T. Oggesen ◽  
Pia Moeller Faaborg ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Anal Cancer ◽  
Late Adverse Effects

A MULTICENTRE SURVEY OF LOCAL DIAGNOSTIC REFERENCE LEVELS AND ACHIEVABLE DOSE FOR CORONARY ANGIOGRAPHY AND PERCUTANEOUS TRANSLUMINAL CORONARY INTERVENTION PROCEDURES IN KOREA

2019 ◽  
Vol 187 (3) ◽  
pp. 378-382
Author(s):  
Jung Su Kim ◽  
Bong-Ki Lee ◽  
Dong Ryeol Ryu ◽  
Kwang Jin Chun ◽  
Hyun-Hee Choi ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Interventional Cardiology ◽  
Coronary Intervention ◽  
Radiation Doses ◽  
Diagnostic Reference Levels ◽  
Reference Levels ◽  
High Radiation ◽  
Exposure Data ◽  
Area Product ◽  
Percutaneous Transluminal

Abstract Interventional cardiology procedures can involve relatively high radiation doses compared to general radiography. During coronary angiography (CAG) and percutaneous transluminal coronary intervention (PCI), the same area is exposed to radiation for a long period. In this study, radiation exposure data of 1071 examinations in Korean hospitals were collected, and the achievable dose (AD) and diagnostic reference levels (DRLs) in actual medical practice for two types of interventional cardiology procedures in Korea were established. In CAG, 75th percentile DRLs and AD of the total kerma-area product were 47.0 and 33.1 Gy·cm 2, respectively. In PCI, those values were 171.3 and 102.6 Gy·cm2, respectively. This is the first study to introduce the DRLs for cardiovascular interventional procedures in Korea. These results will help optimise the interventional cardiology procedures for Korean cardiac centres.

Outcomes of Urinary Diversion for Late Adverse Effects of Gynecologic Radiotherapy

Urology ◽  
2020 ◽  
Vol 144 ◽  
pp. 214-219
Author(s):  
Daniel Smith ◽  
Jacob Albersheim ◽  
Rachel Moses ◽  
Diana O'Dell ◽  
John Stoffel ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Urinary Diversion ◽  
Late Adverse Effects
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