Radioligands for the Vesicular Monoamine Transporter Type 2

2012 ◽  
pp. 235-248
Keyword(s):  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter

scholarly journals Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients

BMJ Open ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. e025533 ◽  
Author(s):  
San San Xu ◽  
Paschal K Alexander ◽  
Yenni Lie ◽  
Vincent Dore ◽  
Svetlana Bozinovski ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Clinical Diagnosis ◽  
Pet Scan ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Rubral Tremor ◽  
Diagnostic Changes ◽  
Community Patients

ObjectivesTo further validate the diagnostic utility of 18F-AV-133 vesicular monoamine transporter type 2 (VMAT2) positron emission tomography (PET) in patients with clinically uncertain parkinsonian syndromes (CUPS) by comparison to clinical diagnosis at 3 years follow-up.Design, setting and participantsIn a previous study, we reported that 18F-AV-133 PET in community patients with CUPS changed diagnosis and management and increased diagnostic confidence. The current diagnosis of this cohort was obtained from the patient and treating specialist and compared with the diagnosis suggested 3 years earlier by the 18F-AV-133 PET. A second 18F-AV-133 PET was available in those with a discordant or inconclusive final diagnosis.Study outcome measuresThe primary end point was the proportion of patients who had a follow-up clinical diagnosis, which was concordant with their initial 18F-AV-133 PET scan. Secondary end points were the proportion of patients who had the same diagnosis at follow-up as that reached after the initial scan and the stability of diagnostic changes made after the first scan.Results81 of the 85 patients previously recruited to the CUPS study had follow-up of which 79 had a clinical diagnosis and 2 remained CUPS. The diagnosis was in agreement with the initial 18F-AV-133 PET scan result in 74 cases. Five patients had a discordant diagnosis; one patient with rubral tremor had a severely abnormal scan that had worsened when rescanned; four cases with normal initial and repeat scans had a clinical diagnosis of Parkinson’s disease. Two patients with suspected genetic disorders remained classified as CUPS and both had normal scans. In the 24 CUPS cohort patients where 18F-AV-133 PET initially changed diagnosis, this change was supported by follow-up diagnosis in all but the one rubral tremor case.Conclusion18F-AV-133 PET is a useful tool in improving diagnostic accuracy in CUPS providing results and diagnostic changes that remain robust after 3 years follow-up.

scholarly journals In Vivo Measurement of Vesicular Monoamine Transporter Type 2 Density in Parkinson Disease with 18F-AV-133

2010 ◽  
Vol 51 (2) ◽  
pp. 223-228 ◽  
Author(s):  
N. Okamura ◽  
V. L. Villemagne ◽  
J. Drago ◽  
S. Pejoska ◽  
R. K. Dhamija ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
In Vivo Measurement

scholarly journals Decreased Vesicular Monoamine Transporter Type 2 Availability in the Striatum Following Chronic Cocaine Self-Administration in Nonhuman Primates

2015 ◽  
Vol 77 (5) ◽  
pp. 488-492 ◽  
Author(s):  
Rajesh Narendran ◽  
Hank P. Jedema ◽  
Brian J. Lopresti ◽  
Neale Scott Mason ◽  
Michael L. Himes ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Vesicular Monoamine Transporter ◽  
Self Administration ◽  
Monoamine Transporter ◽  
Chronic Cocaine

scholarly journals Brain Imaging of Vesicular Monoamine Transporter Type 2 in Healthy Aging Subjects by 18F-FP-(+)-DTBZ PET

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75952 ◽  
Author(s):  
Kun-Ju Lin ◽  
Yi-Hsin Weng ◽  
Chia-Ju Hsieh ◽  
Wey-Yil Lin ◽  
Shiaw-Pyng Wey ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Healthy Aging ◽  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter

Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats

2010 ◽  
Vol 37 (4) ◽  
pp. 413-419 ◽  
Author(s):  
Hsin-Hsin Tsao ◽  
Kun-Ju Lin ◽  
Jyuhn-Huarng Juang ◽  
Daniel M. Skovronsky ◽  
Tzu-Chen Yen ◽  
...  
Keyword(s):  
Vesicular Monoamine Transporter ◽  
Monoamine Transporter ◽  
Binding Characteristics
Sign in / Sign up

Export Citation Format

Share Document