Development and Validation of Animal Models

2012 ◽  
pp. 45-64
Author(s):  
Kenneth Tucker
Keyword(s):  
Animal Models ◽  
Development And Validation

scholarly journals An Overview of Animal Models Related to Schizophrenia

2018 ◽  
Vol 64 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Ian R. Winship ◽  
Serdar M. Dursun ◽  
Glen B. Baker ◽  
Priscila A. Balista ◽  
Ludmyla Kandratavicius ◽  
...  
Keyword(s):  
Animal Models ◽  
Rodent Models ◽  
Preclinical Research ◽  
Drug Induced ◽  
Factors Associated ◽  
Tremendous Progress ◽  
Current Therapies ◽  
Novel Therapeutic Strategies ◽  
Development And Validation ◽  
Core Features

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current therapies. In this brief review, we provide an update regarding the use of animal models to study schizophrenia in an attempt to understand its aetiology and develop novel therapeutic strategies. Tremendous progress has been made developing and validating rodent models that replicate the aetiologies, brain pathologies, and behavioural abnormalities associated with schizophrenia in humans. Here, models are grouped into 3 categories—developmental, drug induced, and genetic—to reflect the heterogeneous risk factors associated with schizophrenia. Each of these models is associated with varied but overlapping pathophysiology, endophenotypes, behavioural abnormalities, and cognitive impairments. Studying schizophrenia using multiple models will permit an understanding of the core features of the disease, thereby facilitating preclinical research aimed at the development and validation of better pharmacotherapies to alter the progression of schizophrenia or alleviate its debilitating symptoms.

Animal models of posthypoxic myoclonus: I. Development and validation

2000 ◽  
Vol 15 (S1) ◽  
pp. 26-30 ◽  
Author(s):  
Daniel D. Truong ◽  
Anumantha Kanthasamy ◽  
Bang Nguyen ◽  
Rae Matsumoto ◽  
Philip Schwartz
Keyword(s):  
Animal Models ◽  
Development And Validation

Development and Validation of a Simple HPLC-UV Method for The Quantification of Andrographolide In Rabbit Plasma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Syukri Y. ◽  
Widarno S. ◽  
Adewiyah A. ◽  
Wibowo A. ◽  
Martien R. ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Animal Models ◽  
Flow Rate ◽  
Mobile Phase ◽  
Biological Sample ◽  
Rabbit Plasma ◽  
Extraction Solvent ◽  
Spiked Plasma ◽  
Relative Standard ◽  
Development And Validation

In this present work, a simple, rapid and accurate HPLC-UV method has been developed for the quantification of andrographolide in rabbit plasma. The assay was performed using an XTerra® MS C18 column (150 mm X 4.6 mm, 5 μm) with a mobile phase of methanol and water (60:40), at 0.8 mL/min flow rate and UV detection of 229 nm. Andrographolide was extracted from a biological sample by applying acetonitrile as a precipitating and extraction solvent. The results showed a good linearity with r = 0.9992; the accuracy reported as % diff was found to be -6.42 – 6.55 % while the recovery was 99.09, 98.55, and 105.14% for low, medium and high spiked plasma, respectively. The precision (reproducibility) reached 1.08–3.20 % RSD for the sample studied. The 2.87 % relative standard deviation (RSD) value for selectivity test indicated a good selectivity of the developed method. The developed method is simple and rapid, so that it can be applied for the quantification andrographolide in animal models during pharmacokinetics studies.

Development and Validation of Animal Models

Biodefense ◽  
2005 ◽  
pp. 41-60
Author(s):  
Kenneth Tucker ◽  
Jaime Anderson
Keyword(s):  
Animal Models ◽  
Development And Validation

Development and validation of gene therapies in autoimmune diseases: Epidemiology to animal models

2010 ◽  
Vol 9 (5) ◽  
pp. A400-A405 ◽  
Author(s):  
Patrick S.C. Leung ◽  
Shang-An Shu ◽  
Thomas P. Kenny ◽  
Ping-Yi Wu ◽  
Mi-Hua Tao
Keyword(s):  
Animal Models ◽  
Autoimmune Diseases ◽  
Gene Therapies ◽  
Development And Validation
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