Biomarker Adaptive Trials

2011 ◽  
pp. 241-258
Keyword(s):  
Adaptive Trials

Exploring changes in treatment effects across design stages in adaptive trials

2009 ◽  
Vol 8 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Tim Friede ◽  
Robin Henderson
Keyword(s):  
Treatment Effects ◽  
Adaptive Trials

scholarly journals Occurrence and Severity of Physiological Disorders of Oil Palm (Elaeis guineensis Jacq. L.) in Uganda

2020 ◽  
Vol 12 (10) ◽  
pp. 86
Author(s):  
Fred Bwayo Masika ◽  
Isaac Danso ◽  
Rossette Nangonzi ◽  
Otuba Moses Amugoli ◽  
Alex Asiimwe ◽  
...  
Keyword(s):  
Oil Palm ◽  
Elaeis Guineensis ◽  
Industrial Sector ◽  
Smallholder Farmer ◽  
Palm Fruit ◽  
Ecological Zones ◽  
Physiological Disorders ◽  
Adaptive Trials ◽  
Bunch Rot ◽  
Corporate Investors

In Africa, oil palm is grown in 25 countries supported by corporate investors. In Uganda, commercial oil palm cultivation began in 2005 in Bugala Islands. Seedlings were imported from countries with established breeding programs. These seedlings were grown in areas with different environmental conditions which have resulted in a number of physiological disorders. The aim of this research was to determine the major physiological disorders in oil palm fruit bunches in Uganda. The study was carried out in the adaptive trials in Kagadi, Bugiri, Buvuma and Masaka Districts and in the different smallholder farmer blocks in Kalangala District. Data was collected on bunch rot, bunch failure and uneven ripening. Sampling was carried out in oil palm plantations above five years of age. Three fields were selected from each unit and three units from each block by the help of the Agricultural Extension Officers (AEOs). Palms were randomly sampled and assessed for presence of bunch rot, bunch failure and uneven ripening symptoms. The incidence was expressed as a percentage of the total number of palms sampled while the severity of bunch rot disease was scored on a scale of 0-4. From the results, the differences in bunch rot and bunch failure in adaptive trials were statistically significant as well as across seasons (P < 0.05). Uneven ripening was not statistically significant and severity of bunch rot in the different farmer blocks in Kalangala was statistically significant (P = 0.03). Uneven ripening was high across smallholder farmer blocks in Kalangala and was statistically significant (P = 0.05) even across seasons (P < 0.05). These results are important for sensitization of farmers on management of oil palm disorders and essential for guiding policy makers and investors as the oil palm industrial sector is being developed in Uganda. This study calls for determination of water deficit at the various ecological zones and its relationship to physiological disorders as a guide for further oil palm estate development.

A Simplified Software for Uncertainty Estimation Using Monte Carlo Method

2020 ◽  
Vol 12 (8) ◽  
pp. 1050-1053
Author(s):  
Jasveer Singh ◽  
L. A. Kumaraswamidhas ◽  
Neha Bura ◽  
Kapil Kaushik ◽  
Nita Dilawar Sharma
Keyword(s):  
Monte Carlo ◽  
Standard Deviation ◽  
Monte Carlo Method ◽  
Measurement Uncertainty ◽  
Standard Uncertainty ◽  
Uncertainty Estimation ◽  
End Points ◽  
The Monte Carlo Method ◽  
Adaptive Trials ◽  
Coverage Interval

The current paper discusses about the application of Monte Carlo method for the evaluation of measurement uncertainty using in-house developed program on C++ platform. The Monte Carlo method can be carried out by fixed trials as well as adaptive trials using this program. The program provides the four parameters viz. estimate of measurand, standard uncertainty in the form of standard deviation and end points of coverage interval as an output.

scholarly journals Adaptive trials, efficiency, and ethics

BMC Medicine ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Spencer Phillips Hey
Keyword(s):  
Adaptive Trials

Adaptive trials receive boost

2010 ◽  
Vol 9 (5) ◽  
pp. 345-348 ◽  
Author(s):  
Dan Jones
Keyword(s):  
Adaptive Trials

scholarly journals Do Bayesian adaptive trials offer advantages for comparative effectiveness research? Protocol for the RE-ADAPT study

2013 ◽  
Vol 10 (5) ◽  
pp. 807-827 ◽  
Author(s):  
Jason T Connor ◽  
Bryan R Luce ◽  
Kristine R Broglio ◽  
K Jack Ishak ◽  
C Daniel Mullins ◽  
...  
Keyword(s):  
Comparative Effectiveness Research ◽  
Comparative Effectiveness ◽  
Effectiveness Research ◽  
Research Protocol ◽  
Adaptive Trials

What should be the role of homogeneity testing in adaptive trials?

2009 ◽  
Vol 8 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Paul Gallo ◽  
Christy Chuang-Stein
Keyword(s):  
Homogeneity Testing ◽  
Adaptive Trials
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