Nitric Oxide from Nanoparticles and Applications to Cardiovascular Health

2011 ◽  
pp. 407-426
Author(s):  
Pedro Cabrales ◽  
Adam Friedman ◽  
Joel Friedman
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health

scholarly journals Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort

mSystems ◽  
2016 ◽  
Vol 1 (5) ◽  
Author(s):  
Antonio Gonzalez ◽  
Embriette Hyde ◽  
Naseer Sangwan ◽  
Jack A. Gilbert ◽  
Erik Viirre ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health ◽  
Commensal Bacteria ◽  
Common Side Effect ◽  
Symbiotic Relationship ◽  
Link Type ◽  
Downstream Effects ◽  
Reducing Bacteria ◽  
Nitrate Reducing Bacteria ◽  
Nitric Oxide Pathway

ABSTRACT Recent work has demonstrated a potentially symbiotic relationship between oral commensal bacteria and humans through the salivary nitrate-nitrite-nitric oxide pathway (C. Duncan et al., Nat Med 1:546–551, 1995, http://dx.doi.org/10.1038/nm0695-546 ). Oral nitrate-reducing bacteria contribute physiologically relevant levels of nitrite and nitric oxide to the human host that may have positive downstream effects on cardiovascular health (V. Kapil et al., Free Radic Biol Med 55:93–100, 2013, http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.013 ). In the work presented here, we used 16S rRNA Illumina sequencing to determine whether a connection exists between oral nitrate-reducing bacteria, nitrates for cardiovascular disease, and migraines, which are a common side effect of nitrate medications (U. Thadani and T. Rodgers, Expert Opin Drug Saf 5:667–674, 2006, http://dx.doi.org/10.1517/14740338.5.5.667 ). Nitrates, such as cardiac therapeutics and food additives, are common headache triggers, with nitric oxide playing an important role. Facultative anaerobic bacteria in the oral cavity may contribute migraine-triggering levels of nitric oxide through the salivary nitrate-nitrite-nitric oxide pathway. Using high-throughput sequencing technologies, we detected observable and significantly higher abundances of nitrate, nitrite, and nitric oxide reductase genes in migraineurs versus nonmigraineurs in samples collected from the oral cavity and a slight but significant difference in fecal samples. IMPORTANCE Recent work has demonstrated a potentially symbiotic relationship between oral commensal bacteria and humans through the salivary nitrate-nitrite-nitric oxide pathway (C. Duncan et al., Nat Med 1:546–551, 1995, http://dx.doi.org/10.1038/nm0695-546 ). Oral nitrate-reducing bacteria contribute physiologically relevant levels of nitrite and nitric oxide to the human host that may have positive downstream effects on cardiovascular health (V. Kapil et al., Free Radic Biol Med 55:93–100, 2013, http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.013 ). In the work presented here, we used 16S rRNA Illumina sequencing to determine whether a connection exists between oral nitrate-reducing bacteria, nitrates for cardiovascular disease, and migraines, which are a common side effect of nitrate medications (U. Thadani and T. Rodgers, Expert Opin Drug Saf 5:667–674, 2006, http://dx.doi.org/10.1517/14740338.5.5.667 ).

Significance of Inorganic Nitrate Supplement in Cardiovascular Health

2021 ◽  
Vol 19 ◽  
Author(s):  
Rupesh Dudhe ◽  
Anshu Chaudhary Dudhe ◽  
Shravan D. Raut
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health ◽  
Substantial Reduction ◽  
General Information ◽  
Pressure Limit ◽  
Inorganic Nitrate ◽  
Nitrate Supplementation ◽  
Sequential Reduction ◽  
Oxide Synthase ◽  
Progression Of Atherosclerosis

Background amp; Objectives: Nitric Oxide (NO) is frequently produced by the enzyme Nitric Oxide Synthase (NOS) and is crucial to the control and effective ness of the cardiovascular system. However, there is substantial reduction in NOS activity with aging that can lead to the development of hypertension and other cardiovascular obstacles. Fortunately, NO can also being produced by sequential reduction of inorganic nitrates supplementation. This proves that NO from inorganic nitrate supplements can provide compensation when NOS activity is inadequate and cardio protective benefits and beyond that provided by healthy NOS system. Discussion: This review focus on the general information about Nitrous oxide, types, mechanism of action of NO & overview of NOS activity is inadequate and cardio protective benefits and beyond that provided by healthy NOS system were often studied for cardiovascular treatments. Conclusion: We concluded that the Natural plant NO is the essential for cardiovascular activity to target site with desired concentration. Moreover, the researchers were focused on Evidence suggested that nitrate supplementation can help regulate blood pressure, limit progression of atherosclerosis, and improve myocardial contractility in both healthy individuals and those with cardiovascular disease.

scholarly journals Potential mechanisms for the effects of far-infrared on the cardiovascular system – a review

VASA ◽  
2019 ◽  
Vol 48 (4) ◽  
pp. 303-312 ◽  
Author(s):  
Richard Shemilt ◽  
Hala Bagabir ◽  
Chim Lang ◽  
Faisel Khan
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular System ◽  
Animal Studies ◽  
Cardiovascular Health ◽  
Far Infrared ◽  
Therapeutic Effects ◽  
Beneficial Effects ◽  
Wide Range ◽  
Shock Proteins ◽  
Endothelial Nitric Oxide

Abstract. Far-infrared (FIR) is a form of thermal radiation, which may have beneficial effects on cardiovascular health. Clinical studies suggest that FIR irradiation may have therapeutic effects in heart failure, myocardial ischaemia and may improve flow and survival of arteriovenous fistula. Animal studies have suggested a wide range of potential mechanisms involving endothelial nitric oxide synthase and nitric oxide bioavailability, oxidative stress, heat shock proteins and endothelial precursor cells. However, the exact cellular and molecular mechanism of FIR on the cardiovascular system remains elusive. The purpose of this review is to discuss the current literature, focusing on mechanistic studies involving the cardiovascular system, and with a view to highlighting areas for future investigation.

scholarly journals L-Arginine/Nitric Oxide Pathway and KCa Channels in Endothelial Cells: A Mini-Review

2020 ◽  
Author(s):  
Marcelo González ◽  
José Carlos Rivas
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Endothelial Function ◽  
Vascular Tone ◽  
Molecular Mechanisms ◽  
Cardiovascular Health ◽  
Kca Channels ◽  
Subsequent Activation ◽  
Regulation Of Vascular Tone

The endothelium is an organ with a key role in the maintenance of cardiovascular health through the regulation of vascular tone, vascular resistance, blood flow, and arterial pressure. These functions are related with the synthesis and release of vasoactive molecules, mainly vasodilators like nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). Both factors are released and diffused from endothelial cells to the smooth muscle cells, where there is a subsequent activation of signaling pathways that finally decrease the intracellular calcium to induce the vascular relaxation. The study of the molecular mechanisms that underlie the endothelial function still is in development, but from the evidence obtained from the endothelial cells in vitro studies are possible to partially describe the pathways to regulate the physiological endothelial function and the disturbances in pathological conditions. In this mini-review, we describe the main mechanisms for NO synthesis and the role of potassium channels related with EDHF. We include schemes and graphical summaries for better understanding of the molecular regulation of vascular tone in the human cardiovascular system.

Low concentrations of adropin are associated with endothelial dysfunction as assessed by flow-mediated dilatation in patients with metabolic syndrome

2017 ◽  
Vol 55 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Coskun U. Oruc ◽  
Yunus E. Akpinar ◽  
Elmire Dervisoglu ◽  
Shirkhan Amikishiyev ◽  
Artur Salmaslıoglu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Cardiovascular Health ◽  
Clinical Symptoms ◽  
Close Association ◽  
Low Concentrations ◽  
Flow Mediated Dilatation ◽  
Student’S T ◽  
Endothelial Nitric Oxide

Abstract Background: In individuals with atherosclerotic risk factors, endothelial dysfunction (ED) appears as an early phase in the development of clinical symptoms. Recent studies indicate that adropin, a newly identified peptide, participates in cardiovascular health through the regulation of several metabolic events including angiogenesis and blood flow. In this study, we aimed to determine the relation of adropin with biochemical and radiologic parameters which reflect ED such as endothelial nitric oxide synthase (eNOS), endothelin 1 (ET-1), nitric oxide (NO) and flow-mediated dilatation (FMD) along with the routine biochemical measurements in patients recently diagnosed with metabolic syndrome (MetS). Methods: Fasting blood samples from 110 patients with MetS diagnosed according to the NCEP ATP III-2005 criteria were collected to measure the concentrations of adropin and other parameters including the lipid profile, insulin and glucose. Serum NOx concentrations were determined by measuring NO2 plus NO3. FMD test was performed by ultrasonography, and patients were stratified as FMD (+) or (–). Data were compared between these two subgroups and also with matching healthy controls (n=50). Biochemical data were evaluated using Student’s t or Mann-Whitney U tests. Results: Fifty-nine subjects had ED (+) and the remaining 101 subjects were ED (–). In the first group, adropin levels were significantly lower than the latter (2.13±1.05 vs. 3.41±1.63 ng/mL, respectively; p<0.001) and independently associated with FMD positivity as assessed by the logistic regression analysis. Conclusions: Low adropin level in circulation is related to ED and has a close association with FMD. Any alterations in its level may be of help in order to assess the development of ED before the occurrence of clinical symptoms in patients with metabolic syndrome.

A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health

2020 ◽  
Vol 78 ◽  
pp. 11-26 ◽  
Author(s):  
Melissa J. Banez ◽  
Matthew I. Geluz ◽  
Anjali Chandra ◽  
Tesnim Hamdan ◽  
Olivia S. Biswas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health ◽  
Systemic Review ◽  
Anti Inflammatory

scholarly journals Dietary Nitrate, Nitric Oxide, and Cardiovascular Health

2015 ◽  
Vol 56 (12) ◽  
pp. 2036-2052 ◽  
Author(s):  
Catherine P. Bondonno ◽  
Kevin D. Croft ◽  
Jonathan M. Hodgson
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health ◽  
Dietary Nitrate

scholarly journals Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 241 ◽  
Author(s):  
Małgorzata Karwowska ◽  
Anna Kononiuk
Keyword(s):  
Nitric Oxide ◽  
Cardiovascular Health ◽  
Nitrosative Stress ◽  
Food Additives ◽  
Meat Products ◽  
Primary Source ◽  
Rapid Expansion ◽  
Meat Industry ◽  
Nitrogen Species ◽  
Scientific Controversy

In the context of impact on human health, nitrite/nitrate and related nitrogen species such as nitric oxide (NO) are a matter of increasing scientific controversy. An increase in the content of reactive nitrogen species may result in nitrosative stress—a deleterious process, which can be an important mediator of damage to cell structures, including lipids, membranes, proteins and DNA. Nitrates and nitrites are widespread in the environment and occur naturally in foods of plant origin as a part of the nitrogen cycle. Additionally, these compounds are used as additives to improve food quality and protect against microbial contamination and chemical changes. Some vegetables such as raw spinach, beets, celery and lettuce are considered to contain high concentrations of nitrates. Due to the high consumption of vegetables, they have been identified as the primary source of nitrates in the human diet. Processed meats are another source of nitrites in our diet because the meat industry uses nitrates/nitrites as additives in the meat curing process. Although the vast majority of consumed nitrates and nitrites come from natural vegetables and fruits rather than food additives, there is currently a great deal of consumer pressure for the production of meat products free of or with reduced quantities of these compounds. This is because, for years, the cancer risks of nitrates/nitrites have been considered, since they potentially convert into the nitrosamines that have carcinogenic effects. This has resulted in the development and rapid expansion of meat products processed with plant-derived nitrates as nitrite alternatives in meat products. On the other hand, recently, these two ions have been discussed as essential nutrients which allow nitric oxide production and thus help cardiovascular health. Thus, this manuscript reviews the main sources of dietary exposure to nitrates and nitrites, metabolism of nitrites/nitrates, and health concerns related to dietary nitrites/nitrates, with particular emphasis on the effect on nitrosative stress, the role of nitrites/nitrates in meat products and alternatives to these additives used in meat products.

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