Large Molecules Containing Icosahedral Boron Clusters Designed for Potential Applications

Boron Science ◽  
2011 ◽  
pp. 701-740 ◽  
Author(s):  
Clara Viñas ◽  
Rosario Núñez ◽  
Francesc Teixidor
Keyword(s):  
Boron Clusters ◽  
Large Molecules ◽  
Potential Applications

ChemInform Abstract: Large Molecules Containing Icosahedral Boron Clusters Designed for Potential Applications

ChemInform ◽  
2012 ◽  
Vol 43 (11) ◽  
pp. no-no
Author(s):  
Clara Vinas ◽  
Rosario Nunez ◽  
Francesc Teixidor
Keyword(s):  
Boron Clusters ◽  
Large Molecules ◽  
Potential Applications

Strong chemisorption of CO on M@Bn− (M = Co, Ir, Rh, Ru, Ta, Nb, n = 8–10) clusters: an implication for wheel boron clusters as CO gas detectors

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82524-82530 ◽  
Author(s):  
Cong Ren ◽  
Weihua Wang ◽  
Chao Guo ◽  
Ping Li ◽  
Yuxia Liu ◽  
...  
Keyword(s):  
Gas Detectors ◽  
Boron Clusters ◽  
Potential Applications ◽  
Co Detection ◽  
Co Gas

The potential applications of wheel M@Bn− clusters in CO detection have been proposed theoretically.

scholarly journals Lipid-Head-Polymer-Tail Chimeric Nanovesicles

2022 ◽  
Author(s):  
Kan Hu ◽  
Aoyuan Cheng ◽  
Dingcheng Zhou ◽  
Yi Luo ◽  
Guoqing Zhang
Keyword(s):  
Cancer Drug ◽  
Nano Materials ◽  
Large Molecules ◽  
Buffer Solutions ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Potential Applications ◽  
Poly Ethylene

Lipid nanovesicles (LNVs) and polymer nanovesicles (PNVs), also known as liposomes and polymersomes, are becoming increasingly vital in global health. One recent example is the widely distributed mRNA Covid-19 vaccines. However, the two major classes of nanovesicles both exhibit their own issues that significantly limit potential applications. Here, by covalently attaching a naturally occurring phosphate “lipid head” and a synthetic polylactide “polymer tail” via facile ring-opening polymerization on a 500-gram scale, a type of “chimeric” nanovesicles (CNVs) can be easily produced. Compared to LNVs, the reported CNVs exhibit reduced permeability for small and large molecules; on the other hand, the CNVs are less hydrophobic and exhibit enhanced tolerance toward proteins in buffer solutions without the need for hydrophilic polymeric corona such as poly(ethylene glycol), in contrast to conventional PNVs. The proof-of-concept in vitro delivery experiments using hydrophilic solutions of fluorescein-PEG, rhodamine-PEG, and anti-cancer drug doxorubicin demonstrate that these CNVs, as a structurally diverse class of nano-materials, are highly promising as alternative carriers for therapeutic molecules in translational nanomedicine.

scholarly journals Periphery Decorated and Core Initiated Neutral and Polyanionic Borane Large Molecules: Forthcoming and Promising Properties for Medicinal Applications

2019 ◽  
Vol 26 (26) ◽  
pp. 5036-5076 ◽  
Author(s):  
Clara Viñas ◽  
Rosario Núñez ◽  
Ines Bennour ◽  
Francesc Teixidor
Keyword(s):  
Self Assembly ◽  
Steric Structure ◽  
Lipid Bilayer Membranes ◽  
Aryl Ether ◽  
Bilayer Membranes ◽  
Boron Clusters ◽  
Large Molecules ◽  
Design And Synthesis ◽  
Novel Applications

A mini-review based on radial growing macromolecules and core initiated Borane periphery decorated with o-carboranes and metallacarboranes that has been developed in the authors laboratories is reported. The review is divided into four sections; three of them are related to the design and synthesis of these large boron-containing molecules and the fourth deals with the unique properties of anionic metallacarborane molecules that provide a glimpse of their potential for their promising use in medicinal applications. Their unique stability along with their geometrical and electronic properties, as well as the precise steric structure of 1,2-closo-C2B10H12 (o-carborane) that has the potential for the incorporation of many substituents: at the carbon (Cc), at the boron and at both carbon and boron vertices, suggests this cluster as an innovative building block or platform for novel applications that cannot be achieved with organic hydrocarbon compounds. Poly(aryl-ether) dendrimers grown from fluorescent cores, such as 1,3,5-triarylbenzene or meso-porphyrins, have been decorated with boron clusters to attain rich boron containing dendrimers. Octasilsesquioxane cubes have been used as a core for its radial growth to get boron-rich large molecules. The unique properties of cobaltabisdicarbollide cluster, which include: i) self-assembly in water to produce monolayer nano-vesicles, ii) crossing lipid bilayer membranes, iii) interacting with membrane cells, iv) facilitating its visualization within cells by Raman and fluorescence techniques and v) their use as molecular platform for “in vivo” imaging are discussed in detail.

Star Polymers: An Overview

2012 ◽  
Vol 5 (2) ◽  
pp. 1675-1684 ◽  
Author(s):  
Rohini Anandrao Patil ◽  
N H Aloorkar ◽  
A S Kulkarni ◽  
D J Ingale
Keyword(s):  
Biomedical Applications ◽  
Star Polymers ◽  
Drug Carriers ◽  
Large Molecules ◽  
Different Types ◽  
Synthesis Properties ◽  
Methods Of Synthesis ◽  
Potential Applications ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

This review article describes the synthesis, properties and some applications of star-shaped polymers. The arms constituted of homo- or co-polymers of different polymers are also reviewed. Methods of synthesis of various types of star-shaped polymers, including “arm first” and “core first” procedures,  is given as an introduction along with some details. Then, the synthesis of star polymers (including miktoarm stars) with strictly defined as well as with varying number of arms and having cores formed from small and/or large molecules: branched, cross-linked, etc., is described. Interest in star-shaped and branched systems based on poly (ethylene oxide) (PEO) is mainly motivated by their potential applications in the biomedical and pharmaceutical areas. The properties and applications of PEO stars are also reported, such as drug carriers, surface modifiers, hydrogels, components of membranes, and also have some biomedical applications. Their potential applications as components of different types of complexes, hydrogels, networks, and ultrathin coatings are indicated. 

Synthesis and Characterization of Vitamin Encapsulated Mesoporous Silica with TEOS

2008 ◽  
Vol 3 ◽  
pp. 89-96 ◽  
Author(s):  
Chang Woo Kim ◽  
Young Hwan Kim ◽  
Hyun Gil Cha ◽  
Young Chul Han ◽  
Young Soo Kang
Keyword(s):  
Mesoporous Silica ◽  
Mesoporous Materials ◽  
Sol Gel ◽  
Molar Ratio ◽  
Confined Space ◽  
Ordered Mesoporous Materials ◽  
Large Molecules ◽  
Ordered Mesoporous ◽  
Sol Gel Process ◽  
Potential Applications

In the past decades, porous materials have attracted great scientific and industrial interest due to their appealing structures and potential applications in separation, purification, catalysis, devices, and so forth. The developing community of ordered mesoporous materials has carried on this exploration of the mesoscopical territory, which promises their unique capacities related to large molecules and their transportation in confined space. Thus rational control and adjustment of pores have been continually focused during the synthesis of ordered mesoporous materials with diverse intrinsic properties. In this work, vitamin C encapsulated mesoporous silica was successfully synthesized with tetraethylorthosilicate (TEOS). TEOS was subjected to sol-gel process in the presence of cetyltrimethylammonium bromide (CTAB). The composition and size of mesoporous silica was controlled by fitting the molar ratio of starting materials. The mesoporous silica can be applied to the field of the cosmetics and bio-medicine as drug delivery.

Spider Silks: An Overview of Their Component Proteins for Hydrophobicity and Biomedical Applications

2020 ◽  
Vol 27 ◽  
Author(s):  
Fan Li ◽  
Chao Bian ◽  
Daiqin Li ◽  
Qiong Shi
Keyword(s):  
Biomedical Applications ◽  
Spider Silk ◽  
Leading Edge ◽  
Structure Evolution ◽  
Silk Proteins ◽  
Large Molecules ◽  
Wide Range ◽  
Silk Glands ◽  
Potential Applications ◽  
Spider Silks

: Spider silks have received extensive attention from scientists and industries around the world because of their remarkable mechanical properties, which include high tensile strength and extensibility. It is a leading-edge biomaterial resource, with a wide range of potential applications. Spider silks are composed of silk proteins, which are usually very large molecules, yet many silk proteins still remain largely underexplored. While there are numerous reviews on spider silks from diverse perspectives, here we provide a most up-to-date overview of the spider silk component protein family in terms of its molecular structure, evolution, hydrophobicity, and biomedical applications. Given the confusion regarding spidroin naming, we emphasize the need for coherent and consistent nomenclature for spidroins and provide recommendations for preexisting spidroin names that are inconsistent with nomenclature. We then review recent advances in the components, identification, and structures of spidroin genes. We next discuss the hydrophobicity of spidroins, with particular attention on the unique aquatic spider silks. Aquatic spider silks are less known but may inspire innovation in biomaterials. Furthermore, we provide new insights into antimicrobial peptides from spider silk glands. Finally, we present possibilities for future uses of spider silks.

The low-resolution 3D-structure of porin, a channel-forming protein in E. coliouter membranes

1983 ◽  
Vol 41 ◽  
pp. 440-441
Author(s):  
A. Engel ◽  
D.L. Dorset ◽  
A. Massalski ◽  
J.P. Rosenbusch
Keyword(s):  
Crystal Packing ◽  
3D Structure ◽  
Gram Negative Bacteria ◽  
Protein Ratio ◽  
Crystal Forms ◽  
Large Molecules ◽  
Functional Studies ◽  
Voltage Dependent ◽  
Planar Membranes ◽  
Hexagonal Arrays

Porins represent a group of channel forming proteins that facilitate diffusion of small solutes across the outer membrane of Gram-negative bacteria, while excluding large molecules (>650 Da). Planar membranes reconstituted from purified matrix porin (OmpF protein) trimers and phospholipids have allowed quantitative functional studies of the voltage-dependent channels and revealed concerted activation of triplets. Under the same reconstitution conditions but using high protein concentrations porin aggregated to 2D lattices suitable for electron microscopy and image processing. Depending on the lipid-to- protein ratio three different crystal packing arrangements were observed: a large (a = 93 Å) and a small (a = 79 Å) hexagonal and a rectangular (a = 79 Å b = 139 Å) form with p3 symmetry for the hexagonal arrays. In all crystal forms distinct stain filled triplet indentations could be seen and were found to be morphologically identical within a resolution of (22 Å). It is tempting to correlate stain triplets with triple channels, but the proof of this hypothesis requires an analysis of the structure in 3 dimensions.

An in situ and ex situ TEM study of the formation of thin cobalt silicide films by molecular beam epitaxy on the silicon (100) surface

1988 ◽  
Vol 46 ◽  
pp. 884-885
Author(s):  
D. Loretto ◽  
J. M. Gibson ◽  
S. M. Yalisove ◽  
R. T. Tung
Keyword(s):  
Molecular Beam Epitaxy ◽  
Molecular Beam ◽  
Defect Density ◽  
High Vacuum ◽  
Ultra High Vacuum ◽  
Ex Situ ◽  
Metal Base ◽  
In Situ Experiments ◽  
Potential Applications

The cobalt disilicide/silicon system has potential applications as a metal-base and as a permeable-base transistor. Although thin, low defect density, films of CoSi2 on Si(111) have been successfully grown, there are reasons to believe that Si(100)/CoSi2 may be better suited to the transmission of electrons at the silicon/silicide interface than Si(111)/CoSi2. A TEM study of the formation of CoSi2 on Si(100) is therefore being conducted. We have previously reported TEM observations on Si(111)/CoSi2 grown both in situ, in an ultra high vacuum (UHV) TEM and ex situ, in a conventional Molecular Beam Epitaxy system.The procedures used for the MBE growth have been described elsewhere. In situ experiments were performed in a JEOL 200CX electron microscope, extensively modified to give a vacuum of better than 10-9 T in the specimen region and the capacity to do in situ sample heating and deposition. Cobalt was deposited onto clean Si(100) samples by thermal evaporation from cobalt-coated Ta filaments.

Microstructure of laser-irradiated, conducting Kapton polyimide

1995 ◽  
Vol 53 ◽  
pp. 502-503
Author(s):  
D. L. Callahan ◽  
Z. Ball ◽  
H. M. Phillips ◽  
R. Sauerbrey
Keyword(s):  
Electron Microscopy ◽  
Phase Transition ◽  
Transmission Electron Microscopy ◽  
Cross Section ◽  
Film Surface ◽  
Cross Sectional ◽  
General Utility ◽  
Transmission Electron ◽  
Considerable Debate ◽  
Potential Applications

Ultraviolet laser-irradiation can be used to induce an insulator-to-conductor phase transition on the surface of Kapton polyimide. Such structures have potential applications as resistors or conductors for VLSI applications as well as general utility electrodes. Although the percolative nature of the phase transformation has been well-established, there has been little definitive work on the mechanism or extent of transformation. In particular, there has been considerable debate about whether or not the transition is primarily photothermal in nature, as we propose, or photochemical. In this study, cross-sectional optical microscopy and transmission electron microscopy are utilized to characterize the nature of microstructural changes associated with the laser-induced pyrolysis of polyimide.Laser-modified polyimide samples initially 12 μm thick were prepared in cross-section by standard ultramicrotomy. Resulting contraction in parallel to the film surface has led to distortions in apparent magnification. The scale bars shown are calibrated for the direction normal to the film surface only.

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