Neuroprotective Effects of Natural Products from Traditional Chinese Herbs

2011 ◽  
pp. 497-524
Author(s):  
Hai Zhang ◽  
Xi Tang
Keyword(s):  
Natural Products ◽  
Chinese Herbs ◽  
Neuroprotective Effects

scholarly journals Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review

2020 ◽  
pp. 1-11
Author(s):  
Xi-jun Wang ◽  
Shi Qiu ◽  
Aihua Zhang ◽  
Jian-hua Miao ◽  
Hui Sun ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurological Disorders ◽  
Chemical Biology ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Neuroprotective Effects ◽  
Alternative Medicines ◽  
Pharmacological Targets ◽  
The World

The incidence of neurological disorders is growing in the world together with an increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathology, which make necessary to search for new therapeutic agents. Natural products, most of them used in phytochemicals from herbal medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Numerous herbs have been applied to neurodegenerative disease treatments as complementary and alternative medicines. In the 21st century, omics-coupled functional pharmacology was developed for neurodegenerative drug discovery from natural products. In this article, we firstly provide the latest understanding of neurological disorders on risk factors, category, diagnosis and treatment, and then specially present an overview of natural products in neuroprotective effects research from chemical biology to pharmacological targets, and also discuss the natural products application and future challenge.

scholarly journals Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Dejene Disasa ◽  
Lihong Cheng ◽  
Majid Manzoor ◽  
Qian Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Antioxidant Activity ◽  
Natural Products ◽  
Survival Rate ◽  
Pc12 Cells ◽  
Neuroprotective Effects ◽  
Replicative Lifespan ◽  
Antioxidative Stress ◽  
Gentiana Rigescens

In the present study, the replicative lifespan assay of yeast was used to guide the isolation of antiaging substance from Gentiana rigescens Franch, a traditional Chinese medicine. A compound with antiaging effect was isolated, and the chemical structure of this molecule as amarogentin was identified by spectral analysis and compared with the reported data. It significantly extended the replicative lifespan of K6001 yeast at doses of 1, 3, and 10 μM. Furthermore, amarogentin improved the survival rate of yeast under oxidative stress by increasing the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and these enzymes’ gene expression. In addition, this compound did not extend the replicative lifespan of sod1, sod2, uth1, and skn7 mutants with K6001 background. These results suggested that amarogentin exhibited antiaging effect on yeast via increase of SOD2, CAT, GPx gene expression, enzyme activity, and antioxidative stress. Moreover, we evaluated antioxidant activity of this natural products using PC12 cell system, a useful model for studying the nervous system at the cellular level. Amarogentin significantly improved the survival rate of PC12 cells under H2O2-induced oxidative stress and increased the activities of SOD and SOD2, and gene expression of SOD2, CAT, GPx, Nrf2, and Bcl-x1. Meanwhile, the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) of PC12 cells were significantly reduced after treatment of the amarogentin. These results indicated that antioxidative stress play an important role for antiaging and neuroprotection of amarogentin. Interestingly, amarogentin exhibited neuritogenic activity in PC12 cells. Therefore, the natural products, amarogentin from G. rigescens with antioxidant activity could be a good candidate molecule to develop drug for treating neurodegenerative diseases.

Inhibition of five natural products from Chinese herbs on the growth of Chattonella marina

2016 ◽  
Vol 23 (17) ◽  
pp. 17793-17800 ◽  
Author(s):  
Fei Liu ◽  
Zheng-Bing He ◽  
Hong-Ye Li ◽  
Jie-Sheng Liu ◽  
Wei-Dong Yang
Keyword(s):  
Natural Products ◽  
Chinese Herbs ◽  
Chattonella Marina

scholarly journals Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

2019 ◽  
Vol 17 (3) ◽  
pp. 247-267 ◽  
Author(s):  
Muneeb U. Rehman ◽  
Adil Farooq Wali ◽  
Anas Ahmad ◽  
Sheeba Shakeel ◽  
Saiema Rasool ◽  
...  
Keyword(s):  
Natural Products ◽  
Large Scale ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Preclinical Models ◽  
Neuroprotective Effects ◽  
Neuroprotective Strategies ◽  
Inflammatory Processes

Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. In vitro and in vivo studies have further established the usefulness of natural products in various preclinical models of neurodegenerative disorders. Natural products include phytoconstituents, like polyphenolic antioxidants, found in herbs, fruits, nuts, vegetables and also in marine and freshwater flora. These phytoconstituents may potentially suppress neurodegeneration and improve memory as well as cognitive functions of the brain. Also, they are known to play a pivotal role in the prevention and cure of different neurodegenerative diseases, such as Alzheimer’s disease, epilepsy, Parkinson’s disease and other neuronal disorders. The large-scale neuro-pharmacological activities of natural products have been documented due to the result of either the inhibition of inflammatory processes, or the up-regulation of various cell survival proteins or a combination of both. Due to the scarcity of human studies on neuroprotective effects of natural products, this review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.

scholarly journals Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Md Sahab Uddin ◽  
Abdullah Al Mamun ◽  
Md Motiar Rahman ◽  
Philippe Jeandet ◽  
Athanasios Alexiou ◽  
...  
Keyword(s):  
Natural Products ◽  
Intracellular Signaling ◽  
Brain Activity ◽  
Radical Scavenging ◽  
Epidemiological Studies ◽  
Neuroprotective Effects ◽  
Genes Encoding ◽  
Endogenous Genes ◽  
Neuroprotective Function ◽  
Intracellular Signaling Molecules

Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effects.

Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder - Parkinson’s Disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Bairong Shen ◽  
Rajeev K. Singla ◽  
Tanya Agarwal ◽  
He Xuefei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural Products ◽  
Dopaminergic Neurons ◽  
Symptomatic Treatment ◽  
Neuroprotective Effects ◽  
Chronic Disorder ◽  
System Disorder ◽  
Pro Inflammatory Cytokines

: Parkinson’s disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, pro-gressively leading to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopa-mine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson’s disease. The exact pathogenesis of Parkinson's dis-ease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches have demonstrated the use of natural products such as ginseng, curcumin, ashwa-gandha, baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited by these natural products are mainly due to their ability to increase dopamine levels in the striatum, manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α-synuclein, induce the autophagy and de-crease the pro-inflammatory cytokines and lipid peroxidation. This paper reviews various natural product studies conducted by the scientists to establish the role of natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective agents.

scholarly journals Neuroprotective Effect of Gui Zhi (Ramulus Cinnamomi) on Ma Huang- (Herb Ephedra-) Induced Toxicity in Rats Treated with a Ma Huang-Gui Zhi Herb Pair

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fang-hao Zheng ◽  
Ping Wei ◽  
Hui-ling Huo ◽  
Xue-feng Xing ◽  
Fei-long Chen ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Oxidative Damage ◽  
Neuroprotective Effect ◽  
Inhibitory Effect ◽  
Chinese Herbs ◽  
Clinical Use ◽  
Sprague Dawley ◽  
Neuroprotective Effects ◽  
Sprague Dawley Rats ◽  
Ma Huang

Herb Ephedra(Ma Huang in Chinese) andRamulus Cinnamomi(Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n=6rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination.

scholarly journals Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

2021 ◽  
Vol 14 (2) ◽  
pp. 86
Author(s):  
Lidia Ciccone ◽  
Jennifer Vandooren ◽  
Susanna Nencetti ◽  
Elisabetta Orlandini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Matrix Metalloproteinases ◽  
Natural Compounds ◽  
Neuroprotective Effects ◽  
Beneficial Role ◽  
Wide Range ◽  
Therapeutic Compounds

Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer’s disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease.

scholarly journals Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5327
Author(s):  
Md. Habibur Rahman ◽  
Johny Bajgai ◽  
Ailyn Fadriquela ◽  
Subham Sharma ◽  
Thuy Thi Trinh ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Neuroprotective Agents ◽  
Future Prospects ◽  
Neuronal Structure ◽  
Neuroprotective Effects ◽  
Scientific Support ◽  
Current Review ◽  
And Function

Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs.

scholarly journals Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model

2020 ◽  
Author(s):  
Yan Xiao Sheng ◽  
Yuan Shui Yang ◽  
Min Xiao Wen ◽  
Xin Zhang ◽  
Feng Yong Ye ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pc12 Cells ◽  
Motor Behavior ◽  
Signal Pathway ◽  
Dopamine Neurons ◽  
Chinese Herbs ◽  
Therapeutic Drug ◽  
Protective Effects ◽  
Neuroprotective Effects

Abstract Background Shende’an tablet (SDA) is a newly developed Chinese herbs formula derived from the chinese traditional medicine Zhenganxifeng Decoction, which is approved for treatment of neurasthenia and insomnia in China. The aim of this study was to investigate the in vitro and in vivo neuroprotective effects of SDA against Parkinson’s disease (PD). Methods In the present work, PC12 cells transfected with or without A53T α-syn genes and MPTP-induced PD mice were used as models to elucidate protective effects of SDA on dopamine (DA) neurons, and the involvement of PGC-1α/Nrf2 signaling in α-syn clearance in PC12/α-syn cells stimulated with Doxycycline (Dox) and reversal of MPTP-induced toxicity in PD mice. Results Our results demonstrated that SDA had neuroprotection effect in dopaminergic PC12 cells with 6-OHDA. It had also displayed efficient dopaminergic neuronal protection and motor behavior alleviation properties in MPTP-induced PD mice. In the PC12/α-syn cells and MPTP-induced PD animal models, SDA was highly efficacious in α-syn clearance associated with activation of PGC-1α/Nrf2 signal pathway. Conclusion The results of our study suggest that SDA could be a potential therapeutic drug for PD through protecting dopamine neurons and alleviating the motor symptoms, and the mechanism might be related to the activation of PGC-1α/Nrf2 signal pathway.

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