The effect dmso on differentiation into hepatocytes-like cell of umbilical cord stem cells

2015 ◽  
Vol 37 (1se) ◽  
Author(s):  
Nguyen Van Hanh ◽  
Vi Dai Lam ◽  
Nguyen Huu Duc ◽  
Do Trung Kien ◽  
Nguyen Viet Linh
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Stem Cells

Therapeutic Potential of Umbilical Cord Stem Cells for Liver Regeneration

2020 ◽  
Vol 15 (3) ◽  
pp. 219-232
Author(s):  
Ifrah Anwar ◽  
Usman A. Ashfaq ◽  
Zeeshan Shokat
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Fas Ligand ◽  
Viral Infections ◽  
Therapeutic Potential ◽  
Cell Types ◽  
Low Risk ◽  
Blood Stem Cells ◽  
Umbilical Cord Stem Cells ◽  
High Regeneration

The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and autoimmunity. Some models for studying liver injury are APAP-based model, Fas ligand (FasL), D-galactosamine/endotoxin (Gal/ET), Concanavalin A, and carbon tetrachloride-based models. The regeneration of the liver can be carried out using umbilical cord blood stem cells which have various advantages over other stem cell types used in liver transplantation. UCB-derived stem cells lack tumorigenicity, have karyotype stability and high immunomodulatory, low risk of graft versus host disease (GVHD), low risk of transmitting somatic mutations or viral infections, and low immunogenicity. They are readily available and their collection is safe and painless. This review focuses on recent development and modern trends in the use of umbilical cord stem cells for the regeneration of liver fibrosis.

Microbial stresses on human umbilical cord stem cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Didem Kart ◽  
Betül Çelebi-Saltik
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Umbilical Cord ◽  
Bacterial Load ◽  
Early Period ◽  
Stress Factors ◽  
Human Umbilical Cord ◽  
Antibacterial Effects ◽  
Hematopoietic Stem ◽  
Umbilical Cord Stem Cells

: Umbilical cord and cord blood are acceptable as attractive sources of mesenchymal and hematopoietic stem cells, since their collection is non-invasive, painless, and does not evoke the ethical concerns. Microorganism-stem cell interaction plays an important role in stem cell self-renewal, differentiation, secretion profile and death. In the literature, few researchers are examining the relationship between pathogenic and commensal bacteria with umbilical cord-derived Mesenchymal Stem Cells (MSCs). These relationships vary depending on the bacterial load and the presence of the immune cell in the environment. Several bacterial pathogens act in the regenerative capacity of MSCs by changing their phenotype, development and viability due to several stress factors that are created by a microorganism such as hypoxia, oxidative stress, etc. On the other hand, the anti-inflammatory and antibacterial effects of MSCs were shown and these phenomena increased when the number of bacteria was high but decreased in the presence of low amounts of bacteria. The antibacterial effects of MSCs increased in the early period of infection, while their effects were decreased in the late period with high inflammatory response and bacterial load. In this review, we discussed the microbial stresses on human umbilical cord stem cells.

scholarly journals Gas-Foaming Calcium Phosphate Cement Scaffold Encapsulating Human Umbilical Cord Stem Cells

2012 ◽  
Vol 18 (7-8) ◽  
pp. 816-827 ◽  
Author(s):  
Wenchuan Chen ◽  
Hongzhi Zhou ◽  
Minghui Tang ◽  
Michael D. Weir ◽  
Chongyun Bao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Umbilical Cord ◽  
Calcium Phosphate Cement ◽  
Human Umbilical Cord ◽  
Umbilical Cord Stem Cells ◽  
Gas Foaming

scholarly journals Historical background of umbilical stem cell culture

2019 ◽  
Vol 7 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Sylwia Borys-Wójcik ◽  
Małgorzata Józkowiak ◽  
Katarzyna Stefańska ◽  
Sandra Knap ◽  
Wojciech Pieńkowski ◽  
...  
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
Historical Background ◽  
Graft Versus Host Reaction ◽  
Safe Procedure ◽  
Modern Times ◽  
Graft Versus Host ◽  
Non Invasive ◽  
Mother And Child ◽  
Umbilical Cord Stem Cells

AbstractUmbilical cord is a waste material, and therefore does not raise ethical concerns related to its use for research and medicine. Stem cells from umbilical cord have a significant advantage over cells from other sources. First, the umbilical cord is an infinite source of stem cells, because it can be taken theoretically during each delivery. Secondly, acquisition of umbilical cord is a non-invasive, safe procedure for mother and child. Thirdly, the transplantation of umbilical cord stem cells is associated with a lower risk of infection and a less-frequent “graft versus host” reaction. In this work, the authors present a historical background of research on the cell from its discovery to modern times characterized by highly advanced methods of obtaining stem cells from umbilical cord and from other sources.

Glory Days

2017 ◽  
pp. 151-172
Author(s):  
Clara Pinto-Correia
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Young Woman ◽  
Umbilical Cord ◽  
Stem Cell Technology ◽  
Cell Technology ◽  
The People ◽  
Umbilical Cord Stem Cells ◽  
Human Side ◽  
Person Account

What was it like to be a young woman in a laboratory that was cloning some of the first mammals? What were the motivations of the people in the laboratory? And why did people want to clone animals in the first place? How did the failure to clone healthy mammals lead to stem cell technology and the banking of umbilical cord stem cells? This first-person account looks at the very human side of cloning.

New Technique for Closure of Alveolar Cleft With Umbilical Cord Stem Cells

2019 ◽  
Vol 30 (3) ◽  
pp. 663-666 ◽  
Author(s):  
Botero Alejandra Garcia ◽  
Madrid Rolando Prada ◽  
Luz Mabel Ávila-Portillo ◽  
Holguin Nancy Rojas ◽  
Viviana Gómez-Ortega ◽  
...  
Keyword(s):  
Stem Cells ◽  
Umbilical Cord ◽  
New Technique ◽  
Alveolar Cleft ◽  
Umbilical Cord Stem Cells

scholarly journals 61: Intranasal administration of exosomes from umbilical cord stem cells to treat perinatal white matter injury

2019 ◽  
Vol 220 (1) ◽  
pp. S49-S50
Author(s):  
Gierin Thomi ◽  
Marianne Joerger-Messerli ◽  
Valérie Haesler ◽  
Daniel V. Surbek ◽  
Andreina Schoeberlein
Keyword(s):  
Stem Cells ◽  
White Matter ◽  
Umbilical Cord ◽  
Intranasal Administration ◽  
White Matter Injury ◽  
Umbilical Cord Stem Cells
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