Three-Dimensional Particle Focusing

Author(s):  
Peter Howell
2014 ◽  
Vol 53 (12) ◽  
pp. 927-933 ◽  
Author(s):  
Sukgyun Cha ◽  
Kyowon Kang ◽  
Jae Bem You ◽  
Sung Gap Im ◽  
Younghun Kim ◽  
...  

Micromachines ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 908
Author(s):  
Chen Ni ◽  
Di Jiang

Particle focusing and separation using viscoelastic microfluidic technology have attracted lots of attention in many applications. In this paper, a three-dimensional lattice Boltzmann method (LBM) coupled with the immersed boundary method (IBM) is employed to study the focusing and separation of particles in viscoelastic fluid. In this method, the viscoelastic fluid is simulated by the LBM with two sets of distribution functions and the fluid–particle interaction is calculated by the IBM. The performance of particle focusing under different microchannel aspect ratios (AR) is explored and the focusing equilibrium positions of the particles with various elasticity numbers and particle diameters are compared to illustrate the mechanism of particle focusing and separation in viscoelastic fluids. The results indicate that, for particle focusing in the square channel (AR = 1), the centerline single focusing becomes a bistable focusing at the centerline and corners as El increases. In the rectangular channels (AR < 1), particles with different diameters have different equilibrium positions. The equilibrium position of large particles is closer to the wall, and large particles have a faster lateral migration speed and few large particles migrate towards the channel center. Compared with the square channel, the rectangular channel is a better design for particle separation.


Lab on a Chip ◽  
2011 ◽  
Vol 11 (14) ◽  
pp. 2319 ◽  
Author(s):  
Jinjie Shi ◽  
Shahrzad Yazdi ◽  
Sz-Chin Steven Lin ◽  
Xiaoyun Ding ◽  
I-Kao Chiang ◽  
...  

2014 ◽  
Vol 17 (4) ◽  
pp. 647-655 ◽  
Author(s):  
Byung Hang Ha ◽  
Kang Soo Lee ◽  
Jin Ho Jung ◽  
Hyung Jin Sung

Author(s):  
Young Won Kim ◽  
Jung Yul Yoo

A conventional flow cytometry is a crucial and versatile instrument that measures the fluorescence and light scattering of individual cell and other particulate or molecular analytes in biomedical research. Recently, there have been many efforts to achieve this conventional flow cytometry on lab-on-a-chip devices powered by microfluidics. One of the key techniques of this instrument is to hydrodynamically focus samples within the sensing area of optical systems in order to optimize detection signals. Recent three-dimensional focusing methods using MEMS technology contain sheath flows with very complex channel geometries. In the present investigation, we demonstrated 3-D particle focusing in a single straight micro-capillary without sheath flows using electro-hydrodynamics. Particle beam was successfully made with a beam diameter of about 10 μm for rigid particles. Proposed device provides critical solutions for simple and innovative 3-D particle focusing method for the applications to the MEMS-based micro-flow cytometry.


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