Role of Inammation and Lifestyle in Chronic Asthma

2016 ◽  
pp. 116-127
Keyword(s):  
Chronic Asthma

Role of Inducible bronchial-associated lymphoid tissue (iBALT) in airway remodelling of murine chronic asthma model

2019 ◽  
Author(s):  
Aya Watanabe ◽  
Atsuyasu Sato ◽  
Tatsushi Mizutani ◽  
Yoko Hamakawa ◽  
Kiyoshi Uemasu ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Airway Remodelling ◽  
Chronic Asthma ◽  
Asthma Model

Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma

2002 ◽  
Vol 32 (7) ◽  
pp. 1104-1111 ◽  
Author(s):  
R. K. Kumar ◽  
C. Herbert ◽  
M. Yang ◽  
A. M. L. Koskinen ◽  
A. N. J. McKenzie ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Remodelling ◽  
Chronic Asthma ◽  
Interleukin 13 ◽  
Eosinophil Accumulation

Meta-Analysis of Controlled Trials of Drug Therapy in Mild Chronic Asthma: The Role of Inhaled Corticosteroids

1994 ◽  
Vol 28 (11) ◽  
pp. 1285-1289 ◽  
Author(s):  
Gary Milavetz ◽  
H. William Kelly ◽  
Hind T. Hatoum ◽  
Glen T. Schumock ◽  
Donald L. Kendzierski
Keyword(s):  
Effect Size ◽  
English Language ◽  
Inhaled Corticosteroids ◽  
Meta Analysis ◽  
Weighted Average ◽  
Chronic Asthma ◽  
Success Rates ◽  
Double Blind ◽  
Effect Size Calculation

OBJECTIVE: To determine the role of inhaled corticosteroids in the treatment of mild chronic asthma. SOURCE OF STUDIES: Searches of MEDLINE and Index Medicus for English language literature dealing with asthma and inhaled corticosteroids. DESIGN: All retrieved articles were subjected to predetermined criteria for inclusion in the meta-analysis. Inclusion criteria centered around randomized, double-blind studies reporting objective clinical endpoint(s) for subjects with mild chronic asthma who were treated for more than seven days. Studies that were included were not allowed to have any predetermined exclusion criteria. RESULTS: The literature search identified 129 articles, of which 41 satisfied some but not all of the criteria for inclusion. Five articles met all the criteria and were subjected to meta-analysis. The total number of subjects was 141. Peak expiratory flow rate (PEFR) was used as the objective endpoint for effect size calculation. Subjecting these five studies to quality review revealed a range of 0.607–0.741, with 1 as the highest attainable quality and 0 the lowest. Reported results for the different studies were found to be homogenous, thus allowing for the calculation of overall effect size. Inclusion of children in some of the studies added variance to the reported studies, but not to the point at which studies would be considered heterogenous. Effect sizes ranged between 0.41 and 0.89, and the overall weighted average effect size for PEFR was 0.59, with the calculated 95 percent confidence interval at 0.32 to 0.84. A tabulated display of binomial effect size for included trials provided ranges of success rates for treatment versus control values. Results of the studies were judged robust, as 92 studies reporting no significant effects are needed to turn the finding of the meta-analysis insignificant. CONCLUSIONS: Based on the results of the meta-analysis, the existing literature suggests a role for inhaled corticosteroids in the treatment of mild chronic asthma.

Role of Acetyl Salicylic Acid and Sodium Metabisulfite in Chronic Childhood Asthma

PEDIATRICS ◽  
1984 ◽  
Vol 73 (5) ◽  
pp. 631-637 ◽  
Author(s):  
S. J. Towns ◽  
C. M. Mellis
Keyword(s):  
Positive Response ◽  
Elimination Diet ◽  
Forced Expiratory Volume ◽  
Sodium Metabisulfite ◽  
Chronic Asthma ◽  
Asthmatic Children ◽  
Restrictive Diet ◽  
Chronic Childhood

The role of a commonly ingested food additive, the preservative sodium metabisulfite (MBS), and aspirin (ASA), in chronic asthma has been studied in 29 children. After 1 week on a strict elimination diet, all 29 children were challenged, in a single-blind fashion, in the pulmonary function laboratory on three consecutive days with placebo, MBS (capsule form and solution), and ASA. Children with a positive response to MBS were prescribed a diet that excluded foods containing MBS. Patients with a positive response to ASA were prescribed a diet excluding medications containing aspirin and natural salicylates. After 3 months on these restricted diets, the children were reassessed to determine whether there had been any therapeutic response. There was a 66% (19/29) incidence of positive challenge (>20% decrease in forced expiratory volume in one second) with MBS and a 21% (6/29) incidence of positive challenge with ASA. None of the children reacted to MBS in capsule form (maximum dose = 100 mg), but 19/29 reacted to MBS in solution with 30 mL of 0.5% citric acid. After 3 months on the restricted diet, four of 19 children on the MBS-free diet and one of six on the salicylate-free diet had objective signs of improvement, namely, reduction in asthma medications and/or improvement in lung function. Unfortunately, compliance with the restrictive diet during this 3 month period was poor, particularly with the ASA-sensitive children. It was demonstrated that two commonly ingested chemicals (MBS and ASA) can provoke bronchospasm in asthmatic children; however, long-term elimination of these substances, particularly natural salicylate, from a child's diet is difficult and does not, in general, improve the chronic asthma.

scholarly journals THE ROLE OF RESPIRATORY VIRUSES IN ACUTE AND CHRONIC ASTHMA

2000 ◽  
Vol 21 (2) ◽  
pp. 289-300 ◽  
Author(s):  
Amjad Tuffaha ◽  
James E. Gern ◽  
Robert F. Lemanske
Keyword(s):  
Respiratory Viruses ◽  
Chronic Asthma
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