Environment and the Role of Inammation in Chronic Pulmonary Diseases: The Silent Mediator

2016 ◽  
pp. 84-115
Keyword(s):  
Pulmonary Diseases ◽  
Chronic Pulmonary Diseases

Review Paper: The Role of Inflammation in Mouse Pulmonary Neoplasia

2009 ◽  
Vol 46 (3) ◽  
pp. 369-390 ◽  
Author(s):  
A. K. Bauer ◽  
E. A. Rondini
Keyword(s):  
Knockout Mouse ◽  
Molecular Mechanisms ◽  
Review Paper ◽  
Therapeutic Strategies ◽  
Pulmonary Diseases ◽  
Inflammatory Pathways ◽  
Chronic Pulmonary Diseases ◽  
Pulmonary Neoplasia ◽  
Pharmacologic Modulation

Inflammation is a risk factor for the development of many types of neoplasia, including skin, colon, gastric, and mammary cancers, among others. Chronic pulmonary diseases, such as chronic bronchitis and asthma, predispose to lung neoplasia. We will review the mouse literature examining the role of inflammation in lung neoplasia, focusing specifically on genetic susceptibility, pharmacologic modulation of inflammatory pathways, and both transgenic and knockout mouse models used to assess pro- and anti-inflammatory pathways involved in lung neoplasia. Identification of molecular mechanisms that govern the association between inflammation and pulmonary neoplasia could provide novel preventive, diagnostic, and therapeutic strategies for a disease in which few biomarkers currently exist.

Chronic pulmonary diseases are independent risk factors for complications after radical nephrectomy

2011 ◽  
Vol 43 (4) ◽  
pp. 1025-1031 ◽  
Author(s):  
Hüsnü Tokgöz ◽  
Bülent Akduman ◽  
İlker Ünal ◽  
Bülent Erol ◽  
Ersöz Akyürek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radical Nephrectomy ◽  
Pulmonary Diseases ◽  
Chronic Pulmonary Diseases ◽  
Independent Risk Factors

scholarly journals Role of thoracic ultrasound in the assessment of pleural and pulmonary diseases

2008 ◽  
Vol 11 (2) ◽  
pp. 39-46 ◽  
Author(s):  
M. Sperandeo ◽  
P. Filabozzi ◽  
A. Varriale ◽  
V. Carnevale ◽  
M.L. Piattelli ◽  
...  
Keyword(s):  
Pulmonary Diseases ◽  
Thoracic Ultrasound

scholarly journals Tissue-informed engineering strategies for modeling human pulmonary diseases

2019 ◽  
Vol 316 (2) ◽  
pp. L303-L320 ◽  
Author(s):  
Kolene E. Bailey ◽  
Michael L. Floren ◽  
Tyler J. D’Ovidio ◽  
Steven R. Lammers ◽  
Kurt R. Stenmark ◽  
...  
Keyword(s):  
Disease Modeling ◽  
Rapid Development ◽  
Rapid Expansion ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Management Options ◽  
Dynamic Changes ◽  
Human Pathology ◽  
Chronic Pulmonary Diseases

Chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH), and chronic obstructive pulmonary disease (COPD), account for staggering morbidity and mortality worldwide but have limited clinical management options available. Although great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, there remains a significant disparity between basic research endeavors and clinical outcomes. This discrepancy is due in part to the failure of many current disease models to recapitulate the dynamic changes that occur during pathogenesis in vivo. As a result, pulmonary medicine has recently experienced a rapid expansion in the application of engineering principles to characterize changes in human tissues in vivo and model the resulting pathogenic alterations in vitro. We envision that engineering strategies using precision biomaterials and advanced biomanufacturing will revolutionize current approaches to disease modeling and accelerate the development and validation of personalized therapies. This review highlights how advances in lung tissue characterization reveal dynamic changes in the structure, mechanics, and composition of the extracellular matrix in chronic pulmonary diseases and how this information paves the way for tissue-informed engineering of more organotypic models of human pathology. Current translational challenges are discussed as well as opportunities to overcome these barriers with precision biomaterial design and advanced biomanufacturing techniques that embody the principles of personalized medicine to facilitate the rapid development of novel therapeutics for this devastating group of chronic diseases.

Differential diagnosis of chronic cardiac and pulmonary insufficiency using echocardiographic examination

1997 ◽  
Vol 78 (4) ◽  
pp. 255-258
Author(s):  
V. P. Kozlov ◽  
T. Ya. Miloslavskaya
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Diseases ◽  
Pulmonary Insufficiency ◽  
Control Group ◽  
Chronic Pulmonary Diseases ◽  
Echocardiographic Examination ◽  
Group A

The echocardiographic examination of 78 patients with chronic pulmonary diseases and 85 patients with various stages of cardiac and pulmonary insufficiency is performed. As many as 28 patients without cardiac and pulmonary diseases are examined as a control group. A group of patients (20) with combination of chronic cardiac and pulmonary diseases is stood out. The results of the investigations revealed the reliable changes of the echocardiographic indices that can be used for the differential diagnosis of chronic cardiac and pulmonary insufficiency.

Remote Electronic Monitoring in Chronic Pulmonary Diseases

2013 ◽  
pp. 173-190
Author(s):  
S. Bella ◽  
F. Murgia
Keyword(s):  
Remote Monitoring ◽  
Validation Studies ◽  
Respiratory Diseases ◽  
Electronic Monitoring ◽  
Pulmonary Diseases ◽  
Economic Viability ◽  
Chronic Respiratory Diseases ◽  
Chronic Pulmonary Diseases ◽  
Operating Method

In this chapter the main aspects of telemonitoring are described and discussed in the field of chronic respiratory diseases. The authors describe the various challenges they faced, in the order in which they did. First, they face the problem of effectiveness of the method, then, the problems related to the economic viability, and finally, the problems related to the operating method. The authors conclude that remote monitoring is a promising method in terms of effectiveness of follow-up that must be performed under well controlled conditions. They still require further validation studies to improve the effectiveness and reduce the effects of new issues that arise.

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