The Role of Inammation in Skin Disease: Inammation, Lifestyle, and Chronic Diseases—The Silent Link

2016 ◽  
pp. 158-183
Keyword(s):  
Chronic Diseases ◽  
Skin Disease

The Role of Oxazolidine Derivatives in the Treatment of Infectious and Chronic Diseases

2017 ◽  
Vol 13 (4) ◽  
Author(s):  
Jeann F. Branco-Junior ◽  
Diego R.C. Teixeira ◽  
Michelly C. Pereira ◽  
Ivan R. Pitta ◽  
Marina R. Galdino-Pitta
Keyword(s):  
Chronic Diseases

The paracaspase MALT1 in psoriasis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stephan Hailfinger ◽  
Klaus Schulze-Osthoff
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Transcription Factors ◽  
Skin Disease ◽  
Cell Types ◽  
Cytokine Receptors ◽  
Molecular Scaffold ◽  
Therapeutic Implications ◽  
Stimulation Of

Abstract Psoriasis is a frequent autoimmune-related skin disease, which involves various cell types such as T cells, keratinocytes and dendritic cells. Genetic variations, such as mutations of CARD14, can promote the development of the disease. CARD14 mutations as well as the stimulation of immune and cytokine receptors activate the paracaspase MALT1, a potent activator of the transcription factors NF-κB and AP-1. The disease-promoting role of MALT1 for psoriasis is mediated by both its protease activity as well as its molecular scaffold function. Here, we review the importance of MALT1-mediated signaling and its therapeutic implications in psoriasis.

scholarly journals SAT0296 SERUM LEPTIN LEVELS IN SYSTEMIC SCLEROSIS PATIENTS WITH ELECTROCARDIOGRAPHIC ABNORMALITIES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1093.1-1093
Author(s):  
G. Pellegrino ◽  
K. Stefanantoni ◽  
F. Facioni ◽  
C. Angelelli ◽  
A. Gigante ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Chronic Diseases ◽  
Cardiac Fibrosis ◽  
Serum Levels ◽  
High Serum ◽  
Control Group ◽  
Pathologic Finding ◽  
Serum Leptin ◽  
Ecg Abnormalities

Background:Electrocardiographic (ECG) abnormalities are described in 25-75% Systemic Sclerosis (SSc) cases and they are associated with other systemic manifestations as well as with a worse prognosis. There is an increasing need for clinical and laboratory biomarkers to ameliorate the diagnostic and therapeutic approaches to patients with ECG abnormalities, due to their actual low sensitivity and specificity. Adipokines are circulating proteins that appear dysregulated in SSc and leptin in particular is synthesized in response to inflammatory conditions and seems to play a proinflammatory and pro-fibrotic action in SSc. Interesting, many studies in the last years have underlined its role in the cardiac remodeling mechanisms and in the development of cardiac fibrosis in other chronic diseases.Objectives:Aim of our study is to evaluate the role of leptin in the development of cardiac rhythm disorders (CRD) during SSc. Furthermore, by the analysis of the clinical and demographical parameters of our SSc patients, we tried to define other possible features associated with increased serum leptin concentration.Methods:We included eighty-five SSc patients, fulfilling the 2013 ACR/EULAR classification criteria, attending the Regional Rare Disease Center of Policlinico Umberto I of Rome. Fifty presented significant CRD at non-invasive diagnostic techniques (12 Lead ECG, 24-hour Holter ECG). Demographic, clinical, conventional cardiovascular risk factors were examined; instrumental and laboratory assessments were obtained, together with ECG recordings. Thirty-five SSc patients without pathologic finding at ECG traces, matched for demographic and clinical features, were recruited as the control group. In all cases, after obtaining written informed consent, blood samples were taken to measure serum levels of leptin using an ELISA assay (Life Technologies-Italia).Results:The fifty SSc patients with CRD (mean age 51±15 years; F:M 41:9) had pulmonary fibrosis (PF) in 32 cases (64%) and a BMI >25Kg/m2in 22 (44%) while in the control group of thirty-five SSc patients (mean age 49±16 years; F:M 33:2) PF was found in 15 (43%) and a BMI >25Kg/m2in 9 (35%); We detected significantly higher median values of serum leptin in SSc patients with CRD compared to the control group (12027 pg/ml IQR 12314 versus 6392 pg/ml IQR 7103;p 0,0009). Additionally, SSc patients with a BMI> 25 kg/m2(31 cases) as well as those with PF (47 cases) showed a significantly higher median serum leptin levels compared to those with BMI <25 kg/m2(13161 pg/ml IQR 13610 versus 8187 pg/ml IQR 8255;p 0,0008) and those without PF (11740 pg/ml IQR 11940 versus 7616 pg/ml IQR 7855;p 0,0079).Conclusion:To our knowledge this is the first report on high serum levels of leptin in SSc patients with CRD that also confirms its increase in those cases with a BMI >25 kg/m2and with PF, according to scientific literature data. The role of leptin in the pathogenesis of SSc remains unclear although it is already known its involvement in the development of cardiac fibrosis during other chronic diseases. On the basis of these results we speculate on leptin involvement in the pathogenesis of CRD during SSc, although further studies are needed with larger cohort of patients.References:[1]Vacca A et al. Rheumatology, 2014[2]Tyndall AJ et al. Ann Rheum Dis, 2010[3]Muresan L et al. Iran J Pub Health, 2017[4]Sanna T et al. Indian Pacing Electrophysiol J, 2009[5]Riccieri V et al. Clin Exp Rheumatol, 2011[6]Żółkiewicz J et al. Arch Dermatol Res, 2019[7]Huby AC et al. Circulation, 2015[8]Shulze PC et al. Clin Chim Acta, 2005[9]Van de Hoogen F et al. Arthritis Rheum, 2013[10]Gui X et al. Biochem Biophys Res Commun, 2018Disclosure of Interests:Greta Pellegrino: None declared, Katia Stefanantoni Consultant of: ItalfarmacoBoehringer Ingelheim, Fausta Facioni: None declared, Carlotta Angelelli: None declared, Antonietta Gigante: None declared, Roberto Badagliacca: None declared, Carmine Dario Vizza: None declared, Sergio Morelli: None declared, Edoardo Rosato: None declared, Valeria Riccieri: None declared

Key role of pediatricians and disease for influenza vaccination in children with high-risk chronic diseases

2020 ◽  
Vol 180 (1) ◽  
pp. 303-306
Author(s):  
Pierre Alauzet ◽  
Aurélie Morand ◽  
Julie Mazenq ◽  
Jean Gaudart ◽  
Emmanuelle Bosdure ◽  
...  
Keyword(s):  
High Risk ◽  
Influenza Vaccination ◽  
Chronic Diseases

scholarly journals Impact of Chronic Diseases and Multimorbidity on Health and Health Care Costs: The Additional Role of Musculoskeletal Disorders

2016 ◽  
Vol 68 (12) ◽  
pp. 1823-1831 ◽  
Author(s):  
Antje van der Zee-Neuen ◽  
Polina Putrik ◽  
Sofia Ramiro ◽  
Andras Keszei ◽  
Rob de Bie ◽  
...  
Keyword(s):  
Health Care ◽  
Chronic Diseases ◽  
Musculoskeletal Disorders ◽  
Health Care Costs ◽  
Care Costs ◽  
Additional Role

scholarly journals Pathophysiology of exercise intolerance in chronic diseases: the role of diminished cardiac performance in mitochondrial and heart failure patients

Open Heart ◽  
2017 ◽  
Vol 4 (2) ◽  
pp. e000632 ◽  
Author(s):  
Jodi McCoy ◽  
Matthew Bates ◽  
Christopher Eggett ◽  
Mario Siervo ◽  
Sophie Cassidy ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Diseases ◽  
Cardiac Performance ◽  
Exercise Intolerance ◽  
Heart Failure Patients

scholarly journals Diet, Genetics, and Disease: A Focus on the Middle East and North Africa Region

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
Akl C. Fahed ◽  
Abdul-Karim M. El-Hage-Sleiman ◽  
Theresa I. Farhat ◽  
Georges M. Nemer
Keyword(s):  
Middle East ◽  
Chronic Diseases ◽  
North Africa ◽  
Genetic Factors ◽  
Future Research ◽  
Micronutrient Deficiencies ◽  
Mena Region ◽  
Mena Countries ◽  
Nutritional Genomics

The Middle East and North Africa (MENA) region suffers a drastic change from a traditional diet to an industrialized diet. This has led to an unparalleled increase in the prevalence of chronic diseases. This review discusses the role of nutritional genomics, or the dietary signature, in these dietary and disease changes in the MENA. The diet-genetics-disease relation is discussed in detail. Selected disease categories in the MENA are discussed starting with a review of their epidemiology in the different MENA countries, followed by an examination of the known genetic factors that have been reported in the disease discussed, whether inside or outside the MENA. Several diet-genetics-disease relationships in the MENA may be contributing to the increased prevalence of civilization disorders of metabolism and micronutrient deficiencies. Future research in the field of nutritional genomics in the MENA is needed to better define these relationships.

scholarly journals The Pivotal Role of Lifestyle Medicine Physician in Managing Chronic Diseases

2020 ◽  
Vol 3 (3) ◽  
pp. 89-93
Author(s):  
Iqbal Akhtar Khan ◽  
Keyword(s):  
Chronic Diseases ◽  
Health Care Expenditure ◽  
Basic Knowledge ◽  
World Health ◽  
Health Study ◽  
Lifestyle Medicine ◽  
Multiple Factors ◽  
Medicine Physician ◽  
Care Guidelines

Background: Chronic diseases are presently the leading cause of morbidity and mortality and are responsible for most of health care expenditure, both in wealthiest countries and those with limited resources. Aims and Objectives: To ratify the competence of skill set Lifestyle Medicine Physician in identifying multiple factors tied to individual’s health. Study Design: To define the attributes of a Lifestyle Medicine Physician. Material and Methods: The role of the Lifestyle Medicine Physician in introducing meaningful, measurable, attainable and sustainable lifestyle interventions which are acceptable, doable and enjoyable for the target group, has been described. In addition the important effect of Spirituality, in the context of the Palliative Care Guidelines of the World Health Assembly and on the increasing toll of Physician Burnout, has been highlighted. Results: Implementation of lifestyle recommendations, under the guidance of Lifestyle Medicine Physician, can significantly reduce premature disability and mortality. Conclusion: The skill set physicians who, with strong basic knowledge, would be able to identify the multiple factors tied to individual ‘s health, provide individualized advice and succefully change menance of chronic lifestyle-related diseases.

scholarly journals Non-Communicable Chronic Diseases: The Role of Neonatal Characteristics

2017 ◽  
Vol 27 (4) ◽  
Author(s):  
Maria Elisabetta Baldassarre ◽  
Antonio Di Mauro ◽  
Annarita Cintoli ◽  
Giuseppina Mincarone ◽  
Silvio Tafuri ◽  
...  
Keyword(s):  
Chronic Diseases

scholarly journals Non-communicable chronic diseases: The role of neonatal characteristics

2015 ◽  
Vol 47 ◽  
pp. e257
Author(s):  
A. Di Mauro ◽  
N. Laforgia ◽  
A.N. Cintoli ◽  
G. Mincarone ◽  
S. Tafuri ◽  
...  
Keyword(s):  
Chronic Diseases
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