Genetic and Epigenetic Alterations in the MAP Kinase and PI3K/Akt Pathways in Thyroid Cancer

2011 ◽  
pp. 27-38
Author(s):  
Mingzhao Xing ◽  
Paul Ladenson
Keyword(s):  
Thyroid Cancer ◽  
Map Kinase ◽  
Epigenetic Alterations

Epigenetic Alterations and Canonical Pathway Disruption in Papillary Thyroid Cancer: A Genome-wide Methylation Analysis

2016 ◽  
Vol 23 (7) ◽  
pp. 2302-2309 ◽  
Author(s):  
Michael G. White ◽  
Sapna Nagar ◽  
Briseis Aschebrook-Kilfoy ◽  
Farzana Jasmine ◽  
Muhammad G. Kibriya ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Canonical Pathway ◽  
Epigenetic Alterations ◽  
Papillary Thyroid ◽  
Methylation Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (61) ◽  
pp. 103014-103031 ◽  
Author(s):  
Katie M. Mishall ◽  
Thomas C. Beadnell ◽  
Brent M. Kuenzi ◽  
Dorothy M. Klimczak ◽  
Giulio Superti-Furga ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Map Kinase ◽  
Src Inhibitor ◽  
Map Kinase Pathways ◽  
Sustained Activation

scholarly journals Metastin Receptor Is Overexpressed in Papillary Thyroid Cancer and Activates MAP Kinase in Thyroid Cancer Cells

2002 ◽  
Vol 87 (5) ◽  
pp. 2399-2399 ◽  
Author(s):  
Matthew D. Ringel ◽  
Elena Hardy ◽  
Victor J. Bernet ◽  
Henry B. Burch ◽  
Frank Schuppert ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Map Kinase ◽  
Cancer Cells ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Thyroid Cancer Cells

scholarly journals The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Rafael Martins de Morais ◽  
Alaor Barra Sobrinho ◽  
Calliandra Maria de Souza Silva ◽  
Jamila Reis de Oliveira ◽  
Izabel Cristina Rodrigues da Silva ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Decisive Role ◽  
Genetic Alterations ◽  
Epigenetic Alterations ◽  
Papillary Thyroid ◽  
Transmembrane Glycoprotein ◽  
Cancer Pathogenesis ◽  
Nis Gene

Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.

Synergistic Effects for Aggressive Thyroid Cancer by Simultaneous Suppression of the MAP Kinase and NF-kB Pathways

2014 ◽  
Vol 186 (2) ◽  
pp. 560
Author(s):  
K. Tsumagari ◽  
D. Slakey ◽  
D. Mondal ◽  
A. Abdel-Mageed ◽  
E. Kandil
Keyword(s):  
Thyroid Cancer ◽  
Map Kinase ◽  
Synergistic Effects
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