- Bioactive Coatings for Implanted Devices

2016 ◽  
pp. 486-505
Keyword(s):  
Bioactive Coatings ◽  
Implanted Devices

scholarly journals Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 638
Author(s):  
M. Joana F. Pinheiro ◽  
Joana P. Costa ◽  
Fernanda Marques ◽  
Nuno P. Mira ◽  
M. Fernanda N. N. Carvalho ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Medical Devices ◽  
Mammalian Cells ◽  
Surface Engineering ◽  
Pathogenic Yeast ◽  
Bioactive Coatings ◽  
Clinical Strains ◽  
Persistent Infections ◽  
Compound Q ◽  
Significant Step

Currently there is a gap between the rate of new antifungal development and the emergence of resistance among Candida clinical strains, particularly threatened by the extreme adhesiveness of C. albicans to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OC10H14N(C6H4)2NC10H14O}] (compound P) and [{Ag(OC10H14NC6H4CH3-p)}2(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of Candida albicans and Candida glabrata clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by C. albicans and colonize the surface of indwelling medical devices, resulting in persistent infections. Functionalization of stainless steel with polycaprolactone (PCL) matrix embedded with compounds P or Q was reported for the first time to inhibit the colonization of C. albicans by 82% and 75%, respectively. The coating of PCL loaded with Q or P did not cause cytotoxic effects in mammalian cells, demonstrating the biocompatibility of the explored approach. The identification and further exploration of new approaches for surface engineering based on new molecules that can sensitize resistant strains, as herein demonstrated for complexes P and Q, is a significant step forward to improve the successful treatment of candidiasis.

scholarly journals In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Hyun Ok Ham ◽  
Zheng Qu ◽  
Carolyn A. Haller ◽  
Brent M. Dorr ◽  
Erbin Dai ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Sortase A ◽  
Bioactive Coatings ◽  
In Situ Regeneration

Safety Assessment of Subconjunctivally Implanted Devices Containing Latanoprost in Dutch-Belted Rabbits

2013 ◽  
Vol 29 (6) ◽  
pp. 574-585 ◽  
Author(s):  
Bart A. Jessen ◽  
Michael H.I. Shiue ◽  
Harjeet Kaur ◽  
Paul Miller ◽  
Robert Leedle ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Implanted Devices

scholarly journals 16-40: Changes in activation of coagulation cascade in patients with implanted devices

EP Europace ◽  
2016 ◽  
Vol 18 (suppl_1) ◽  
pp. i10-i10
Author(s):  
Milan Sepsi ◽  
Peter Scheer ◽  
Gabriela Chlupova ◽  
Tereza Novakova ◽  
David Pospisil ◽  
...  
Keyword(s):  
Coagulation Cascade ◽  
Implanted Devices

Magnesium-sputtered titanium for the formation of bioactive coatings

2009 ◽  
Vol 5 (6) ◽  
pp. 2338-2347 ◽  
Author(s):  
Suzette Ibasco ◽  
Faleh Tamimi ◽  
Robert Meszaros ◽  
Damien Le Nihouannen ◽  
Srikar Vengallatore ◽  
...  
Keyword(s):  
Bioactive Coatings
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