Inƒuence of Ion Exchange Resin Particle Size and Size Distribution on Chromatographic Separation in Sweetener Industries

2016 ◽  
pp. 166-191 ◽  
RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2729-2732
Author(s):  
Jueun Kim ◽  
Bhupendra Kumar Singh ◽  
Wooyong Um

Ball mill ground IER waste form resulted in relatively better homogeneous waste distribution and displayed superior Cs leachability compared with the same polymer waste form prepared with non-ground IER.


2020 ◽  
Vol 10 (1-s) ◽  
pp. 51-61 ◽  
Author(s):  
Jigar Vyas ◽  
Kapil Daxini ◽  
Jitendra Patel

Moxifloxacin (MOX) is a fluoroquinolone anti-infective drug, indicated for the treatment of bacterial conjunctivitis. The drug is soluble in water but still produces low ocular bioavailability due to biological barriers and so it requires dosing for two/three times a day. The present study was designed to formulate, optimize and characterize polymeric Nanoparticles MOX for ocular administration using Ion Exchange Resin (IER). IER-nanoparticles were prepared by media milling method, formulation/process parameters were optimized based on evaluation parameters such as color of nanosuspension, sedimentation behaviour, particle size and zeta potential. MOX-IER nanosuspensions were prepared at different stoichiometric ratio of MOX and IER and characterized by entrapment efficiency, pH, particle size and zeta potential of nanosuspension. In vitro release study of optimized batch MNIER3 exhibited sustained release pattern which follows Korsmeyer-Peppas model with Fickian diffusion mechanism for drug release. Based on these results optimized batch of MOX-IER nanosuspension formulated in the laboratory was found suitable for ocular delivery. Keywords: Moxifloxacin; nanoparticles, nanosuspension; media milling; stoichiometric ratio; sedimentation behaviour.


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