Modes of Action and Physiological Effects of Thyroid Hormones in Fish

2020 ◽  
pp. 767-808 ◽  
Keyword(s):  
Thyroid Hormones ◽  
Physiological Effects ◽  
Modes Of Action

The effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury

1980 ◽  
Vol 53 (3) ◽  
pp. 381-384 ◽  
Author(s):  
Charles H. Tator ◽  
Richard H. C. van der Jagt
Keyword(s):  
Spinal Cord ◽  
Thyroid Hormones ◽  
Spinal Cord Compression ◽  
Functional Recovery ◽  
Cord Compression ◽  
Injured Spinal Cord ◽  
Compression Injury ◽  
Content Type ◽  
Modes Of Action ◽  
Fine Print

✓ The effect of triiodothyronine (T3) or thyroxine (T4) on functional recovery after acute spinal cord compression injury in the rat was assessed. Rats treated with T3 for 14 consecutive days after injury showed significantly improved recovery at 12 and 16 weeks, and rats treated with T4 for 4 days after injury showed significantly improved recovery at 12 weeks as compared with control animals. The possible modes of action of these two hormones on the injured spinal cord are briefly discussed.

Physiological Effects of the Thyroid Hormones

1975 ◽  
pp. 125-228
Author(s):  
Ya. Kh. Turakulov ◽  
A. I. Gagel’gans ◽  
N. S. Salakhova ◽  
A. K. Mirakhmedov ◽  
L. M. Gol’ber ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Physiological Effects

COMPARISON OF THE EFFECTS OF VARIOUS GOITROGENS ON THE BIOSYNTHESIS OF THYROID HORMONES IN VITRO

1961 ◽  
Vol 36 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Shiro Iino
Keyword(s):  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Potent Inhibitor ◽  
Relative Activity ◽  
Antithyroid Drugs ◽  
Modes Of Action ◽  
Antithyroid Activity ◽  
Rat Thyroid ◽  
Rat Thyroid Gland

ABSTRACT The effect of various goitrogens on in vitro biosynthesis of thyroid horhomes was studied. The compounds in decreasing order of relative activity to completely inhibit DIT formation were 1-methyl-2-mercaptoimidazole (MIA), thiouracil (TU); propylthiouracil PTU) and goitrin; thiourea and methylthiouracil (MTU). Those in decreasing order of relative activity to completely inhibit MIT formation were MIA; PTU, MTU, TU and thiourea; goitrin. Of the compounds tested MIA was thus the most potent inhibitor of the rat thyroid gland in vitro. The conversion of monoiodotyrosine to diiodotyrosine was more sensitive to every goitrogen than the iodination of tyrosine to form monoiodotyrosine. The modes of action of these antithyroid drugs seemed to be approximately the same, except for goitrin, which showed very weak inhibition of MIT formation. Progoitrin, the precursor of goitrin, did not seem to possess any antithyroid activity.

259 Thyroid hormones in chronic heart failure outpatients

2006 ◽  
Vol 5 (1) ◽  
pp. 56-56
Author(s):  
A BARISON ◽  
L RONDININI ◽  
S GUIDERI ◽  
M COCEANI ◽  
M SCARLATTINI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Thyroid Hormones

The Role of Zinc in Thyroid Hormones Metabolism

2019 ◽  
Vol 89 (1-2) ◽  
pp. 80-88 ◽  
Author(s):  
Juliana Soares Severo ◽  
Jennifer Beatriz Silva Morais ◽  
Taynáh Emannuelle Coelho de Freitas ◽  
Ana Letícia Pereira Andrade ◽  
Mayara Monte Feitosa ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Scientific Evidence ◽  
Thyroid Stimulating Hormone ◽  
Zinc Transporters ◽  
Serum Concentrations ◽  
Metabolic Adaptations ◽  
Serum T3 ◽  
Regulatory Effects ◽  
Shed Light

Abstract. Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

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