A Cryogenic-Temperature Ion Mobility Mass Spectrometer for Improved Ion Mobility Resolution

2010 ◽  
pp. 137-151 ◽  
Author(s):  
Jody May ◽  
David Russell
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Cryogenic Temperature ◽  
Mobility Resolution

scholarly journals Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer

2018 ◽  
Vol 17 (12) ◽  
pp. 2534-2545 ◽  
Author(s):  
Florian Meier ◽  
Andreas-David Brunner ◽  
Scarlet Koch ◽  
Heiner Koch ◽  
Markus Lubeck ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Trapped Ion

Development of an Atmospheric Pressure Ion Mobility Spectrometer–Mass Spectrometer with an Orthogonal Acceleration Electrostatic Sector TOF Mass Analyzer

2013 ◽  
Vol 85 (19) ◽  
pp. 9003-9012 ◽  
Author(s):  
Alexey A. Sysoev ◽  
Denis M. Chernyshev ◽  
Sergey S. Poteshin ◽  
Alexander V. Karpov ◽  
Oleg I. Fomin ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Atmospheric Pressure ◽  
Mass Analyzer ◽  
Ion Mobility Spectrometer ◽  
Orthogonal Acceleration

Ion Mobility-Mass Spectrometer Interface for Collisional Activation of Mobility Separated Ions

2009 ◽  
Vol 81 (2) ◽  
pp. 618-624 ◽  
Author(s):  
Francisco A. Fernandez-Lima ◽  
Christopher Becker ◽  
Kent J. Gillig ◽  
William K. Russell ◽  
Shane E. Tichy ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Collisional Activation

Separation of asparagine, valine and tetraethylammonium ions overlapping in an ion mobility spectrum by clustering with methanol introduced as a modifier into the buffer gas

2015 ◽  
Vol 7 (3) ◽  
pp. 863-869 ◽  
Author(s):  
R. Fernandez-Maestre ◽  
C. Wu ◽  
H. H. Hill
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Buffer Gas ◽  
Mobility Spectrum ◽  
Ion Mobility Spectrometer ◽  
Tetraalkylammonium Ions ◽  
Tetraethylammonium Ions

We introduced methanol into the buffer gas of an ion mobility spectrometer-mass spectrometer and mobilities changed depending on ion structures; baseline separation of valine, asparagine, and tetraalkylammonium ions was achieved.

scholarly journals A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients

2019 ◽  
Author(s):  
Dorte B. Bekker-Jensen ◽  
Ana Martínez del Val ◽  
Sophia Steigerwald ◽  
Patrick Rüther ◽  
Kyle Fort ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Rat Tissues ◽  
Label Free ◽  
Mass Spectrometers ◽  
Proteome Coverage ◽  
Data Independent Acquisition ◽  
Orbitrap Mass Spectrometer ◽  
Peptide Precursors ◽  
Free Quantification

ABSTRACTState-of-the-art proteomics-grade mass spectrometers can measure peptide precursors and their fragments with ppm mass accuracy at sequencing speeds of tens of peptides per second with attomolar sensitivity. Here we describe a compact and robust quadrupole-orbitrap mass spectrometer equipped with a front-end High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Interface. The performance of the Orbitrap Exploris 480 mass spectrometer is evaluated in data-dependent acquisition (DDA) and data-independent acquisition (DIA) modes in combination with FAIMS. We demonstrate that different compensation voltages (CVs) for FAIMS are optimal for DDA and DIA, respectively. Combining DIA with FAIMS using single CVs, the instrument surpasses 2500 unique peptides identified per minute. This enables quantification of >5000 proteins with short online LC gradients delivered by the Evosep One LC system allowing acquisition of 60 samples per day. The raw sensitivity of the instrument is evaluated by analyzing 5 ng of a HeLa digest from which >1000 proteins were reproducibly identified with 5 minute LC gradients using DIA-FAIMS. To demonstrate the versatility of the instrument we recorded an organ-wide map of proteome expression across 12 rat tissues quantified by tandem mass tags and label-free quantification using DIA with FAIMS to a depth of >10,000 proteins.

A new, higher resolution, ion mobility mass spectrometer

2009 ◽  
Vol 287 (1-3) ◽  
pp. 46-57 ◽  
Author(s):  
Paul R. Kemper ◽  
Nicholas F. Dupuis ◽  
Michael T. Bowers
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility
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