- Dietary Components, Epigenetics, and Cancer

2010 ◽  
pp. 94-125
Keyword(s):  
Dietary Components

The Food-gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome

2019 ◽  
Vol 26 (19) ◽  
pp. 3567-3583 ◽  
Author(s):  
Maria De Angelis ◽  
Gabriella Garruti ◽  
Fabio Minervini ◽  
Leonilde Bonfrate ◽  
Piero Portincasa ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Dietary Habits ◽  
Short Chain Fatty Acids ◽  
Human Organism ◽  
Immune Functions ◽  
Intestinal Microbes ◽  
Dietary Components ◽  
Dietary Treatments ◽  
The Relationship

Gut microbiota, the largest symbiont community hosted in human organism, is emerging as a pivotal player in the relationship between dietary habits and health. Oral and, especially, intestinal microbes metabolize dietary components, affecting human health by producing harmful or beneficial metabolites, which are involved in the incidence and progression of several intestinal related and non-related diseases. Habitual diet (Western, Agrarian and Mediterranean omnivore diets, vegetarian, vegan and gluten-free diets) drives the composition of the gut microbiota and metabolome. Within the dietary components, polymers (mainly fibers, proteins, fat and polyphenols) that are not hydrolyzed by human enzymes seem to be the main leads of the metabolic pathways of gut microbiota, which in turn directly influence the human metabolome. Specific relationships between diet and microbes, microbes and metabolites, microbes and immune functions and microbes and/or their metabolites and some human diseases are being established. Dietary treatments with fibers are the most effective to benefit the metabolome profile, by improving the synthesis of short chain fatty acids and decreasing the level of molecules, such as p-cresyl sulfate, indoxyl sulfate and trimethylamine N-oxide, involved in disease state. Based on the axis diet-microbiota-health, this review aims at describing the most recent knowledge oriented towards a profitable use of diet to provide benefits to human health, both directly and indirectly, through the activity of gut microbiota.

scholarly journals Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 265
Author(s):  
Maria-Luisa Pérez-Lozano ◽  
Annabelle Cesaro ◽  
Marija Mazor ◽  
Eric Esteve ◽  
Sabine Berteina-Raboin ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Natural Product ◽  
Treatment Strategies ◽  
Cartilage Degradation ◽  
Therapeutic Strategies ◽  
Clinical Models ◽  
Osteoarthritic Joint ◽  
Dietary Components ◽  
New Treatment ◽  
Review Current

Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.

scholarly journals Defining Nutritional and Functional Niches of Legumes: A Call for Clarity to Distinguish a Future Role for Pulses in the Dietary Guidelines for Americans

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1100
Author(s):  
Chelsea Didinger ◽  
Henry J. Thompson
Keyword(s):  
Public Health ◽  
Health Care Professionals ◽  
Weight Status ◽  
Dietary Guidelines ◽  
Health Concern ◽  
Healthy Weight ◽  
Food Groups ◽  
Rich Diversity ◽  
Dietary Guidelines For Americans ◽  
Dietary Components

Legume food crops can contribute to the solution of diet-related public health challenges. The rich diversity of the botanical family Fabaceae (Leguminosae) allows legumes to fill numerous nutritional niches. Pulses (i.e., a subgroup of legumes including chickpeas, cowpeas, dry beans, dry peas, and lentils) are a nutrient-dense food that could play a key role in eliminating the dramatic underconsumption of dietary fiber and potassium, two dietary components of public health concern, all while maintaining a caloric intake that promotes a healthy weight status. However, incorrect use of terminology—in the commercial and scientific literature as well as in publications and materials prepared for the consuming public—creates confusion and represents a barrier to dissemination of clear dietary guideline messaging. The use of accurate terminology and a simple classification scheme can promote public health through differentiation among types of legumes, better informing the development and implementation of nutritional policies and allowing health care professionals and the public to capitalize on the health benefits associated with different legumes. Although inconsistent grouping of legumes exists across countries, the recently released 2020–2025 Dietary Guidelines for Americans (DGA) were chosen to illustrate potential challenges faced and areas for clarification. In the 2020–2025 DGA, pulses are included in two food groups: the protein food group and ‘beans, peas, lentils’ vegetable subgroup. To evaluate the potential of pulses to contribute to intake of key dietary components within calorie recommendations, we compared 100 kilocalorie edible portions of pulses versus other foods. These comparisons demonstrate the unique nutritional profile of pulses and the opportunity afforded by this type of legume to address public health concerns, which can be greatly advanced by reducing confusion through global harmonization of terminology.

scholarly journals Identification of an Obesogenic Dietary Pattern Using Partial Least Squares in a Nationally-Representative Sample of Canadian Adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 552-552
Author(s):  
Alena Ng ◽  
Mahsa Jessri ◽  
Mary L'Abbé
Keyword(s):  
Least Squares ◽  
Partial Least Squares ◽  
Dietary Pattern ◽  
Fast Food ◽  
Representative Sample ◽  
Hybrid Methods ◽  
Nutritional Epidemiology ◽  
Obesogenic Diet ◽  
Dietary Components ◽  
Nationally Representative

Abstract Objectives Hybrid methods of dietary patterns analysis have emerged as a unique and informative way to study diet-disease relationships in nutritional epidemiology research. The objectives of this research were to identify an obesogenic dietary pattern using weighted PLS in nationally-representative Canadian survey data, and to identify key foods and/or beverages associated with the defined obesogenic pattern. Methods Data from one 24-hr dietary recall data from the cross-sectional Canadian Community Health Survey-Nutrition (CCHS) 2015 (n = 12,110 adults) were used. Weighed partial least squares (wPLS) was used to identify an obesogenic dietary pattern from 40 standardized food and/or beverage categories using the variables energy density, fibre density, and total fat as outcomes. The association between the derived dietary pattern and likelihood of obesity was examined using weighted multivariate logistic regression. Key dietary components highly associated with the derived pattern were identified. Results Compared to quartile one (i.e., those least adherent to an obesogenic dietary pattern), those in quartile four had a 2.40-fold increased odds of being obese (OR = 2.40, 95% CI = 1.91, 3.02, P-trend < 0.0001) with a monotonically increasing trend. Using a factor loading significance cut-off of ≥|0.17|, three food/beverage categories loaded positively for the derived obesogenic dietary pattern: fast food, carbonated drinks and salty snacks. Seven food/beverage categories loaded negatively (i.e., in the protective direction): consumption of whole fruits, orange vegetables, “other” vegetables (including vegetable juice), whole grains, dark green vegetables, legumes and soy, and pasta and rice. Conclusions This study pinpoints key dietary components that are associated with obesity and consumed among a nationally-representative sample of Canadians adults. Compared to a similarly-defined obesogenic diet identified by our research group in 2004, the top contributors to a Canadian-specific obesogenic diet in 2015 have remained consistent. This evidence may aid in developing targeted policies and dietary interventions for obesity and chronic disease prevention. Funding Sources Supported by grants from the Burroughs Wellcome Fund Innovation in Regulatory Science Award and the Canadian Institutes of Health Research.

scholarly journals A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2428
Author(s):  
Małgorzata Guz ◽  
Witold Jeleniewicz ◽  
Anna Malm ◽  
Izabela Korona-Glowniak
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Current Knowledge ◽  
Vital Role ◽  
Disease States ◽  
Health And Disease ◽  
Dietary Components ◽  
Non Coding Rnas

A still growing interest between human nutrition in relation to health and disease states can be observed. Dietary components shape the composition of microbiota colonizing our gastrointestinal tract which play a vital role in maintaining human health. There is a strong evidence that diet, gut microbiota and their metabolites significantly influence our epigenome, particularly through the modulation of microRNAs. These group of small non-coding RNAs maintain cellular homeostasis, however any changes leading to impaired expression of miRNAs contribute to the development of different pathologies, including neoplastic diseases. Imbalance of intestinal microbiota due to diet is primary associated with the development of colorectal cancer as well as other types of cancers. In the present work we summarize current knowledge with particular emphasis on diet-microbiota-miRNAs axis and its relation to the development of colorectal cancer.

Antimutagenic activities of various lactic acid bacteria against food mutagens: heterocyclic amines

2002 ◽  
Vol 69 (2) ◽  
pp. 335-341 ◽  
Author(s):  
EMMANUELLE TAVAN ◽  
CHANTAL CAYUELA ◽  
JEAN-MICHEL ANTOINE ◽  
PIERRETTE CASSAND
Keyword(s):  
Dairy Products ◽  
Dietary Habits ◽  
Inverse Correlation ◽  
Heterocyclic Amines ◽  
Colorectal Cancers ◽  
Breast Cancers ◽  
Environmental Component ◽  
Dietary Components ◽  
Industrialised Countries ◽  
Food Mutagens

Antimutagenic properties of various dietary components have been investigated in many studies, in order to find compounds protective against the various steps of carcinogenesis. Indeed, cancer is now the principal cause of death in industrialised countries and treatment is still difficult. Thus, research in prevention is of extreme importance. While, the etiology of most cancers has an environmental component, colon or breast cancers are highly linked to dietary habits (up to 50% of colorectal cancers are due to diet; Riboli et al. 1996). In this context, Boutron et al. (1996) showed inverse correlation between consumption of dairy products and colorectal cancer in France.

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