Optimal Response-Adaptive Randomization for Clinical Trials

2010 ◽  
pp. 15-1-15-13
Author(s):  
Lanju Zhang ◽  
William Rosenberger
Keyword(s):  
Clinical Trials ◽  
Adaptive Randomization ◽  
Optimal Response

Comparison of response adaptive randomization features in multiarm clinical trials with control

2020 ◽  
Vol 19 (5) ◽  
pp. 602-612
Author(s):  
Kert Viele ◽  
Benjamin R. Saville ◽  
Anna McGlothlin ◽  
Kristine Broglio
Keyword(s):  
Clinical Trials ◽  
Adaptive Randomization

scholarly journals Adaptive Randomization for BMT Clinical Trials With Both Efficacy and Futility Outcomes

2011 ◽  
Vol 17 (2) ◽  
pp. S198-S199
Author(s):  
R.T. Sabo ◽  
C.H. Roberts ◽  
A.A. Toor ◽  
H.M. Chung ◽  
W.B. Clark ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Adaptive Randomization

Bayesian doubly adaptive randomization in clinical trials

2017 ◽  
Vol 60 (12) ◽  
pp. 2503-2514
Author(s):  
YiKe Xiao ◽  
ZhongQiang Liu ◽  
FeiFang Hu
Keyword(s):  
Clinical Trials ◽  
Adaptive Randomization

scholarly journals Gastric sarcoidosis

2017 ◽  
Vol 145 (3-4) ◽  
pp. 195-198
Author(s):  
Svetlana Kasikovic-Lecic ◽  
Violeta Vucinic ◽  
Milana Panjkovic ◽  
Biljana Kukic
Keyword(s):  
Clinical Trials ◽  
Rare Case ◽  
Systemic Disease ◽  
Pulmonary Sarcoidosis ◽  
Glucocorticoid Therapy ◽  
Acid Therapy ◽  
Optimal Response ◽  
Clinical Diagnostic ◽  
Systemic Glucocorticoids

Introduction. Sarcoidosis is a systemic disease with a 90% predilection for the lungs, but any organ can be involved. Gastric sarcoidosis may be a component of a generalized process, while isolated gastric sarcoidosis is very rare. Case Outline. We describe a rare case of biopsy-proven gastric sarcoidosis in a 45-year-old woman with pulmonary sarcoidosis in remission, and highlight the importance of gastroscopy and biopsy to confirm the diagnosis. Her optimal response to anti-acid therapy required no alternate (glucocorticoid) therapy. We briefly review the clinical, diagnostic, and therapeutic aspects of gastric sarcoidosis. Conclusion. Glucocorticoids remain the cornerstone of the sarcoidosis treatment, although it has been insufficiently documented by clinical trials. The decision to treat sarcoid patients with systemic glucocorticoids is largely based upon the severity of symptoms. The anti-acid therapy may be an alternative in milder cases, as demonstrated in our patient.

scholarly journals Response adaptive randomization procedures in seamless phase II/III clinical trials

2019 ◽  
Vol 30 (1) ◽  
pp. 3-17
Author(s):  
Hongjian Zhu ◽  
Jin Piao ◽  
J. Jack Lee ◽  
Feifang Hu ◽  
Lixin Zhang
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Adaptive Randomization
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