Anti-inflammatory Herbal Medicines for the Control of Pain

2009 ◽  
Author(s):  
Julia Vlachojannis ◽  
Rujee Duke ◽  
Van Tran ◽  
Colin Duke ◽  
Sigrun Chrubasik
Keyword(s):  
Herbal Medicines ◽  
Anti Inflammatory

Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review

2018 ◽  
Vol 12 (1) ◽  
pp. 39-58 ◽  
Author(s):  
Mohd. I. Yatoo ◽  
Arumugam Gopalakrishnan ◽  
Archana Saxena ◽  
Oveas R. Parray ◽  
Noore A. Tufani ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Herbal Medicines ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
I-Cheng Chen ◽  
Te-Hsien Lin ◽  
Yu-Hsuan Hsieh ◽  
Chih-Ying Chao ◽  
Yih-Ru Wu ◽  
...  
Keyword(s):  
Cell Model ◽  
Neuronal Cell Death ◽  
Herbal Medicines ◽  
Neuronal Cell ◽  
Tau Proteins ◽  
No Production ◽  
Study Results ◽  
Apoptosis Protein ◽  
Anti Inflammatory ◽  
Protein Array Analysis

Misfolded tau proteins induce accumulation of free radicals and promote neuroinflammation by activating microglia-releasing proinflammatory cytokines, leading to neuronal cell death. Traditional Chinese herbal medicines (CHMs) have been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of formulated CHMs Bai-Shao (made of Paeonia lactiflora), Gan-Cao (made of Glycyrrhiza uralensis), and Shaoyao Gancao Tang (SG-Tang, made of P. lactiflora and G. uralensis at 1 : 1 ratio) in cell model of tauopathy. Our results showed that SG-Tang displayed a greater antioxidative and antiaggregation effect than Bai-Shao and Gan-Cao and a stronger anti-inflammatory activity than Bai-Shao but similar to Gan-Cao. In inducible 293/SH-SY5Y cells expressing proaggregant human tau repeat domain (ΔK280 tauRD), SG-Tang reduced tau misfolding and reactive oxygen species (ROS) level in ΔK280 tauRD 293 cells and promoted neurite outgrowth in ΔK280 tauRD SH-SY5Y cells. Furthermore, SG-Tang displayed anti-inflammatory effects by reducing nitric oxide (NO) production in mouse BV-2 microglia and increased cell viability of ΔK280 tauRD-expressing SH-SY5Y cells inflamed by BV-2 conditioned medium. To uncover the neuroprotective mechanisms of SG-Tang, apoptosis protein array analysis of inflamed tau expressing SH-SY5Y cells was conducted and the suppression of proapoptotic proteins was confirmed. In conclusion, SG-Tang displays neuroprotection by exerting antioxidative and anti-inflammatory activities to suppress neuronal apoptosis in human tau cell models. The study results lay the base for future applications of SG-Tang on tau animal models to validate its effect of reducing tau misfolding and potential disease modification.

scholarly journals Anti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smoke

2018 ◽  
Vol 99 ◽  
pp. 591-597 ◽  
Author(s):  
Lucas Possebon ◽  
Isabella de Souza Lima Lebron ◽  
Ligia Furlan da Silva ◽  
Julia Tagliaferri Paletta ◽  
Bruna Gabrieli Glad ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cigarette Smoke ◽  
Herbal Medicines ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Anti Inflammatory

scholarly journals The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Leiming Zhang ◽  
Xiaoli Li ◽  
Tianhao Ying ◽  
Tian Wang ◽  
Fenghua Fu
Keyword(s):  
Side Effects ◽  
Glycyrrhizic Acid ◽  
Herbal Medicines ◽  
Cochrane Library ◽  
Hormone Synthesis ◽  
Increased Risk ◽  
Anti Inflammatory ◽  
High Doses ◽  
Risk Of Treatment ◽  
Plant Sources

Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compounds derived from natural plant sources have been reported to exert anti-inflammatory activity by interacting with the glucocorticoid receptor (GR), likely owing to their chemical similarity to glucocorticoids, or by regulating GR, without a concomitant risk of treatment-related side effects such as osteoporosis. Other herbal compounds can counteract the pathogenic processes underlying glucocorticoid-induced osteoporosis (GIOP) by regulating homeostatic bone metabolic processes. Herein, we systematically searched the PubMed, Embase, and Cochrane library databases to identify articles discussing such compounds published as of May 01, 2021. Compounds reported to exert anti-inflammatory glucocorticoid-like activity without inducing GIOP include escin, ginsenosides, and glycyrrhizic acid, while compounds reported to alleviate GIOP by improving osteoblast function or modulating steroid hormone synthesis include tanshinol and icariin.

scholarly journals Screening of Chloroform and Methanolic Bark Extracts of Commiphora caudata for its In-vitro Anti-bacterial, Anti-fungal and In-vivo Anti-inflammatory Activity

2021 ◽  
Vol 12 (4) ◽  
pp. 853-857
Author(s):  
Raju H V ◽  
Kishori P Sutar ◽  
Prasanna S Sutar ◽  
Shailendra S Suryawanshi ◽  
Nisha S Shirkoli
Keyword(s):  
Research Work ◽  
Extraction Procedure ◽  
Herbal Medicines ◽  
Developed Countries ◽  
Inflammatory Activity ◽  
Methanolic Extracts ◽  
Anti Inflammatory ◽  
Bacteria And Fungi

Herbal medicines and their preparations have been widely used from the thousands of years in developing and developed countries in the primary health care of society and community. They have great demand due its safety, efficacy with minimum side or adverse effects. Commiphora caudata. It’s known as konda mava in kannada, ikkata in Sanskrit and hill mango in English. It’s widely used in the management of various disorders. Hence the identification of bioactive fractions from various parts of selected medicinal plant is important. In the present research work an attempt has been made to screen and assess the antibacterial, antifungal and anti-inflammatory activities of Commiphora caudata barks. The barks of selected plant material were collected, authenticated, powdered and subjected for extraction procedure. The extracts were screened for presence of various phytoconstituents. The antibacterial activity of chloroform and methanolic extracts were performed against various strains of bacteria and fungi. The extracts also were investigated for its in-vivo anti-inflammatory activity. The result of investigation concludes that chloroform and methanolic extract of plant were potential to inhibit the growth of selected strains of microorganism and also produced potential anti-inflammatory effect.

scholarly journals Anti-Inflammatory Activities of Pentaherbs formula and Its Influence on Gut Microbiota in Allergic Asthma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2776 ◽  
Author(s):  
Miranda Tsang ◽  
Sau-Wan Cheng ◽  
Jing Zhu ◽  
Karam Atli ◽  
Ben Chan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Allergic Asthma ◽  
Herbal Medicines ◽  
Oral Intake ◽  
Allergic Diseases ◽  
Short Chain Fatty Acids ◽  
Mice Model ◽  
Anti Inflammatory

Allergic asthma is a highly prevalent airway inflammatory disease, which involves the interaction between the immune system, environmental and genetic factors. Co-relation between allergic asthma and gut microbiota upon the change of diet have been widely reported, implicating that oral intake of alternative medicines possess a potential in the management of allergic asthma. Previous clinical, in vivo, and in vitro studies have shown that the Pentaherbs formula (PHF) comprising five traditional Chinese herbal medicines Lonicerae Flos, Menthae Herba, Phellodendri Cortex, Moutan Cortex, and Atractylodis Rhizoma possesses an anti-allergic and anti-inflammatory potential through suppressing various immune effector cells. In the present study, to further investigate the anti-inflammatory activities of PHF in allergic asthma, intragastrical administration of PHF was found to reduce airway hyperresponsiveness, airway wall remodeling and goblet cells hyperplasia in an ovalbumin (OVA)-induced allergic asthma mice model. PHF also significantly suppressed pulmonary eosinophilia and asthma-related cytokines IL-4 and IL-33 in bronchoalveolar lavage (BAL) fluid. In addition, PHF modulated the splenic regulatory T cells population, up-regulated regulatory interleukin (IL)-10 in serum, altered the microbial community structure and the short chain fatty acids content in the gut of the asthmatic mice. This study sheds light on the anti-inflammatory activities of PHF on allergic asthma. It also provides novel in vivo evidence that herbal medicines can ameliorate symptoms of allergic diseases may potentially prevent the development of subsequent atopic disorder such as allergic asthma through the influence of the gut microbiota.

Phytochemical Analysis and In-vitro Anti-Diabetic and Anti- Inflammatory study of root extract of Apama siliquosa LAMK.

2021 ◽  
pp. 5838-5842
Author(s):  
Manu Jose ◽  
Stephin Baby ◽  
Dona Mathew ◽  
Naurin Muhammed ◽  
Jayalakshmi P M
Keyword(s):  
Inflammatory Diseases ◽  
Herbal Medicines ◽  
Alpha Amylase ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Inhibition Assay ◽  
Ic50 Value ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

The demand for herbal medicines in many pharmaceutical sectors is growing at a drastic rate due to their improved pharmacological actions, minimal side effects and cost-effectiveness. Anti-inflammatory phytochemicals are found to be efficacious against the treatment of inflammatory diseases like rheumatoid arthritis, glomerulonephritis, hepatitis, inflammatory bowel disease, etc. Anti-diabetic phytochemicals are found to treat the increasing incidence of diabetes prevalent globally. This work aims to perform the phytochemical screening and to evaluate the antidiabetic and anti-inflammatory activity of crude extract of Apama siliquosa Lamk. The method employed for obtaining the active principles includes soxhlation technique with methanol as solvent. The anti-inflammatory property was studied in vitro using inhibition of albumin denaturation technique as well as heat-induced hemolysis and IC50 value was found to be 39.5μg/ml and 36.30μg/ml respectively. The anti-diabetic activity was estimated using the alpha-amylase inhibition assay and Glucose diffusion inhibitory study. The IC50 value for alpha-amylase inhibition assay was found to be 15.75μg/ml. It also shows a strong inhibition of glucose across the dialysis membrane.

Screening for Anti-inflammatory and Bronchorelaxant Activities of 12 Commonly Used Chinese Herbal Medicines

2011 ◽  
Vol 26 (6) ◽  
pp. 915-925 ◽  
Author(s):  
Grace G. L. Yue ◽  
Ben C. L. Chan ◽  
Hin-Fai Kwok ◽  
Ming-Ho To ◽  
Kam-Lun Hon ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Anti Inflammatory

Sulfation of Quercitrin, Epicatechin and Rutin by Human Cytosolic Sulfotransferases (SULTs): Differential Effects of SULT Genetic Polymorphisms

Planta Medica ◽  
2021 ◽  
Author(s):  
Xue Mei ◽  
Saud A. Gohal ◽  
Eid S. Alatwi ◽  
Ying Hui ◽  
Chunyan Yang ◽  
...  
Keyword(s):  
Kinetic Parameters ◽  
Chronic Inflammation ◽  
Genetic Polymorphisms ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Biochemical Basis ◽  
Differential Effects ◽  
Sulfotransferase 1A1 ◽  
Radix Bupleuri ◽  
Anti Inflammatory

AbstractRadix Bupleuri is one of the most widely used herbal medicines in China for the treatment of fever, pain, and/or chronic inflammation. Quercitrin, epicatechin, and rutin, the flavonoids present in Radix Bupleuri, have been reported to display anti-inflammatory, antitumor, and antioxidant biological activities among others. Sulfation has been reported to play an important role in the metabolism of flavonoids. In this study, we aimed to systematically identify the human cytosolic sulfotransferase enzymes that are capable of catalyzing the sulfation of quercitrin, epicatechin, and rutin. Of the thirteen known human cytosolic sulfotransferases, three (cytosolic sulfotransferase 1A1, cytosolic sulfotransferase 1C2, and cytosolic sulfotransferase 1C4) displayed sulfating activity toward quercitrin, three (cytosolic sulfotransferase 1A1, cytosolic sulfotransferase 1A3, and cytosolic sulfotransferase 1C4) displayed sulfating activity toward epicatechin, and six (cytosolic sulfotransferase 1A1, cytosolic sulfotransferase 1A2, cytosolic sulfotransferase 1A3, cytosolic sulfotransferase 1B1, cytosolic sulfotransferase 1C4, and cytosolic sulfotransferase 1E1) displayed sulfating activity toward rutin. The kinetic parameters of the cytosolic sulfotransferases that showed the strongest sulfating activities were determined. To investigate the effects of genetic polymorphisms on the sulfation of quercitrin, epicatechin, and rutin, individual panels of cytosolic sulfotransferase allozymes previously prepared were analyzed and shown to display differential sulfating activities toward each of the three flavonoids. Taken together, these results provided a biochemical basis underlying the metabolism of quercitrin, epicatechin, and rutin through sulfation in humans.

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