EXPERIMENTAL Preparation of Biomass

2016 ◽  
pp. 225-238
Keyword(s):  
Experimental Preparation

scholarly journals ФАРМАКО–ТОКСИКОЛОГІЧНА ОЦІНКА ПРЕПАРАТУ «ЦИФЛУР»

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 214-217
Author(s):  
L.V. Nagorna
Keyword(s):  
Mucous Membrane ◽  
Concentrate Solution ◽  
Intact Skin ◽  
Toxicological Evaluation ◽  
Second Stage ◽  
Test Concentration ◽  
Veterinary Importance ◽  
Oily Solution ◽  
Experimental Preparation ◽  
Observation Period

The results of pharmaco–toxicological evaluation insectoacaricid preparation «Tsiflur», in particular the study of locally irritating effect of the drug on the skin and mucous membranes of rabbits eyes. The preparation «Tsiflur» – representative of synth pyrethroids, in its composition has the active ingredient cyfluthrin, production NPF «Brovafarma». According to the manufacturer's instructions, the preparation recommended for the control of flying midges and other representatives akaroentomofauny that have veterinary importance. The tool is a clear oily solution of a yellowish color.Experimental studies were conducted on rabbits analogues in several stages. In the first phase we studied local irritant effect of the preparation in varying degrees of dilution when applied to intact skin of rabbits. The aim of the second stage of the research was to determine the local irritant effect of the d preparation on the mucous membrane of the eyes of rabbits.It has been established that the preparation «Tsiflur» in the test concentration (1: 100, 1: 200, 1: 400 concentrate solution) during the observation period did not show locally irritating effects in a single application to the intact areas of the skin of rabbits. Monitoring the bellies of the experiment showed no redness, swelling, thickening of the skin folds and the pain response to palpation place application of the preparation. Not set also signs of toxic effects of native preparation «Tsiflur», when applied under similar conditions. The reaction of the skin of animals per application experimental preparation was valued at 0 points. In the study of the preparation in a similar concentration on the possibility of providing local irritant effect on the mucous membrane of the eyes of rabbits determined that the native application of the preparation led to the emergence of a slight reddening of the eye mucosa and the appearance of watery eyes. These symptoms disappear without any intervention on the second day of the experiment. The reaction to the introduction of the preparation «Tsiflur» was estimated at 1 point, for each identified symptom. 

Pre-Reduced Iron-ore Pellets, their Experimental Preparation

JOM ◽  
1961 ◽  
Vol 13 (4) ◽  
pp. 314-315
Author(s):  
J. P. Hansen ◽  
N. B. Melcher ◽  
M. M. Fine
Keyword(s):  
Iron Ore ◽  
Iron Ore Pellets ◽  
Ore Pellets ◽  
Experimental Preparation

Pulmonary circulation demonstration using an isolated rat lung model.

1998 ◽  
Vol 275 (6) ◽  
pp. S85
Author(s):  
T C Resta ◽  
L M Eichinger ◽  
R D Russ ◽  
B R Walker
Keyword(s):  
Pulmonary Circulation ◽  
Lung Model ◽  
Physiological Data ◽  
Teaching Tool ◽  
Rat Lung ◽  
Laboratory Exercise ◽  
Vascular Physiology ◽  
Basic Concepts ◽  
Isolated Rat Lung ◽  
Experimental Preparation

We have developed a pulmonary circulation laboratory exercise that effectively illustrates basic concepts typically taught in a graduate physiology curriculum. The demonstration uses an isolated, perfused rat lung model to delineate the mechanisms by which pulmonary vascular resistance can be altered either passively or in an active manner by contraction or relaxation of vascular smooth muscle. The exercise further offers an opportunity to closely observe an experimental preparation commonly used to study the pulmonary circulation and allows students the opportunity to interpret the resulting physiological data. Student evaluations indicate that the demonstration was received with enthusiasm and provides an effective teaching tool for reinforcing concepts in pulmonary vascular physiology.

Cytochrome P-450-dependent vasodilation of rat kidney by arachidonic acid

1991 ◽  
Vol 261 (3) ◽  
pp. H714-H719 ◽  
Author(s):  
A. O. Oyekan ◽  
J. C. McGiff ◽  
J. Quilley
Keyword(s):  
Arachidonic Acid ◽  
Cobalt Chloride ◽  
Stannous Chloride ◽  
Rat Kidney ◽  
Vasodilator Effect ◽  
Vasodilator Response ◽  
Cytochrome P 450 ◽  
Experimental Preparation ◽  
In Vivo Induction

Our previous studies indicated a role for cytochrome P-450-dependent enzymes in generating the mediators of the vasodilator effect of arachidonic acid (AA) in the preconstricted indomethacin-treated perfused kidney of the rat. We report that in vivo induction of cytochrome P-450 enzymes with 3-methylcholanthrene-beta-naphthoflavone or dexamethasone enhanced the renal vasodilator effect of AA in this experimental preparation. Conversely, depletion of cytochrome P-450 enzymes with stannous chloride or cobalt chloride diminished the vasodilator response to AA. Injection of AA resulted in the release of relaxant material into the renal effluent detected by superfusion of rabbit aortic rings. Inhibition of cytochrome P-450 with 7-ethoxyresorufin reduced the release of vasorelaxant material. Metabolism of labeled AA by the kidney revealed four peaks of radioactivity that were recovered from the renal effluent. The heights of these peaks were reduced by 7-ethoxyresorufin. These results provide further evidence for cytochrome P-450-dependent metabolism of AA to one or more vasodilator products by the rat kidney.

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