In Vivo Nondestructive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy

2008 ◽  
pp. 205-236
Author(s):  
Yi Ping Du ◽  
Yukihiro Ozaki ◽  
Katsuhiko Maruo ◽  
Hideyuki Shinzawa ◽  
Ilya Fine
Keyword(s):  
Blood Glucose ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Nondestructive Measurement

scholarly journals Noninvasive Prediction of Glucose by Near-Infrared Diffuse Reflectance Spectroscopy

1999 ◽  
Vol 45 (9) ◽  
pp. 1651-1658 ◽  
Author(s):  
Stephen F Malin ◽  
Timothy L Ruchti ◽  
Thomas B Blank ◽  
Suresh N Thennadil ◽  
Stephen L Monfre
Keyword(s):  
Blood Glucose ◽  
Wavelength Range ◽  
Standard Error ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
Calibration Model ◽  
Calibration Models ◽  
Blood Glucose Concentrations

Abstract Background: Self-monitoring of blood glucose by diabetics is crucial in the reduction of complications related to diabetes. Current monitoring techniques are invasive and painful, and discourage regular use. The aim of this study was to demonstrate the use of near-infrared (NIR) diffuse reflectance over the 1050–2450 nm wavelength range for noninvasive monitoring of blood glucose. Methods: Two approaches were used to develop calibration models for predicting the concentration of blood glucose. In the first approach, seven diabetic subjects were studied over a 35-day period with random collection of NIR spectra. Corresponding blood samples were collected for analyte analysis during the collection of each NIR spectrum. The second approach involved three nondiabetic subjects and the use of oral glucose tolerance tests (OGTTs) over multiple days to cause fluctuations in blood glucose concentrations. Twenty NIR spectra were collected over the 3.5-h test, with 16 corresponding blood specimens taken for analyte analysis. Results: Statistically valid calibration models were developed on three of the seven diabetic subjects. The mean standard error of prediction through cross-validation was 1.41 mmol/L (25 mg/dL). The results from the OGTT testing of three nondiabetic subjects yielded a mean standard error of calibration of 1.1 mmol/L (20 mg/dL). Validation of the calibration model with an independent test set produced a mean standard error of prediction equivalent to 1.03 mmol/L (19 mg/dL). Conclusions: These data provide preliminary evidence and allow cautious optimism that NIR diffuse reflectance spectroscopy using the 1050–2450 nm wavelength range can be used to predict blood glucose concentrations noninvasively. Substantial research is still required to validate whether this technology is a viable tool for long-term home diagnostic use by diabetics.

In VivoNoninvasive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy

2003 ◽  
Vol 57 (10) ◽  
pp. 1236-1244 ◽  
Author(s):  
Katsuhiko Maruo ◽  
Mitsuhiro Tsurugi ◽  
Mamoru Tamura ◽  
Yukihiro Ozaki
Keyword(s):  
Blood Glucose ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy

scholarly journals Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chao-Chun Yang ◽  
Yun-Yo Yen ◽  
Chao-Kai Hsu ◽  
Nan-Yu Cheng ◽  
Shih-Yu Tzeng ◽  
...  
Keyword(s):  
Barrier Function ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Normal Skin ◽  
Reflectance Spectroscopy ◽  
Psoriatic Skin ◽  
Efficacy Evaluation ◽  
Epidermal Barrier

AbstractPsoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.

Quantitative in vivo detection of adipose tissue browning using diffuse reflectance spectroscopy in near-infrared II window

2018 ◽  
Vol 11 (12) ◽  
pp. e201800135 ◽  
Author(s):  
Kapil Dev ◽  
U. S Dinish ◽  
Smarajit Chakraborty ◽  
Renzhe Bi ◽  
Stefan Andersson-Engels ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Reflectance Spectroscopy ◽  
In Vivo Detection ◽  
Tissue Browning

scholarly journals Investigation of Water Bonding Status of Normal and Psoriatic Skin in Vivo Using Diffuse Reflectance Spectroscopy

2020 ◽  
Author(s):  
Chao-Chun Yang ◽  
Yun-Yo Yen ◽  
Chao-Kai Hsu ◽  
Nan-Yu Cheng ◽  
Shih-Yu Tzeng ◽  
...  
Keyword(s):  
Barrier Function ◽  
Diffuse Reflectance ◽  
Near Infrared ◽  
Diffuse Reflectance Spectroscopy ◽  
Normal Skin ◽  
Reflectance Spectroscopy ◽  
Psoriatic Skin ◽  
Efficacy Evaluation ◽  
Epidermal Barrier

Abstract Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.

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