Controlled Drug Release Of Oral Dosage Forms

In the pharmaceutical technology, paediatric population still presents the greatest challenge in terms of developing flexible and appropriate drug dosage forms. As for many medicines, there is a lack of paediatric dosage forms adequate for a child’s age; it is a prevailing practice to use off label formulations. Children need balanced and personalized treatment, patient-friendly preparations, as well as therapy that facilitates dosing and thus eliminates frequent drug administration, which can be ensured by modified release (MR) forms. MR formulations are commonly used in adult therapy, while rarely available for children. The aim of this article is to elucidate how to modify drug release in paediatric oral dosage forms, discuss the already accessible technologies and to introduce novel approaches of manufacturing with regard to paediatric population.

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3D-Printed Mesoporous Carrier System for Delivery of Poorly Soluble Drugs

Pharmaceutics ◽

10.3390/pharmaceutics13071096 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1096

Author(s):

Christos S. Katsiotis ◽

Michelle Åhlén ◽

Maria Strømme ◽

Ken Welch

Keyword(s):

Drug Release ◽

Mesoporous Materials ◽

Dosage Forms ◽

Oral Dosage ◽

Great Promise ◽

Poorly Soluble Drugs ◽

Drug Concentrations ◽

Poorly Soluble ◽

3D Printed ◽

Oral Dosage Forms

Fused deposition modelling (FDM) is the most extensively employed 3D-printing technique used in pharmaceutical applications, and offers fast and facile formulation development of personalized dosage forms. In the present study, mesoporous materials were incorporated into a thermoplastic filament produced via hot-melt extrusion and used to produce oral dosage forms via FDM. Mesoporous materials are known to be highly effective for the amorphization and stabilization of poorly soluble drugs, and were therefore studied in order to determine their ability to enhance the drug-release properties in 3D-printed tablets. Celecoxib was selected as the model poorly soluble drug, and was loaded into mesoporous silica (MCM-41) or mesoporous magnesium carbonate. In vitro drug release tests showed that the printed tablets produced up to 3.6 and 1.5 times higher drug concentrations, and up to 4.4 and 1.9 times higher release percentages, compared to the crystalline drug or the corresponding plain drug-loaded mesoporous materials, respectively. This novel approach utilizing drug-loaded mesoporous materials in a printed tablet via FDM shows great promise in achieving personalized oral dosage forms for poorly soluble drugs.

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Supercritical Fluid Technology for the Development of 3D Printed Controlled Drug Release Dosage Forms

Pharmaceutics ◽

10.3390/pharmaceutics13040543 ◽

2021 ◽

Vol 13 (4) ◽

pp. 543

Author(s):

Johannes Schmid ◽

Martin A. Wahl ◽

Rolf Daniels

Keyword(s):

Drug Release ◽

Pore Size ◽

Dissolution Rate ◽

Supercritical Co2 ◽

Controlled Drug Release ◽

Drug Carriers ◽

Dosage Forms ◽

Oral Dosage ◽

Pore Sizes ◽

3D Printed

Supercritical CO2 loading of preformed 3D printed drug carriers with active pharmaceutical ingredients (APIs) shows great potential in the development of oral dosage forms for future personalized medicine. We designed 3D printed scaffold like drug carriers with varying pore sizes made from polylactic acid (PLA) using a fused deposition modelling (FDM) 3D printer. The 3D printed drug carriers were then loaded with Ibuprofen as a model drug, employing the controlled particle deposition (CPD) process from supercritical CO2. Carriers with varying pore sizes (0.027–0.125 mm) were constructed and loaded with Ibuprofen to yield drug-loaded carriers with a total amount of 0.83–2.67 mg API (0.32–1.41% w/w). Dissolution studies of the carriers show a significantly decreasing dissolution rate with decreasing pore sizes with a mean dissolution time (MDT) of 8.7 min for the largest pore size and 128.2 min for the smallest pore size. The API dissolution mechanism from the carriers was determined to be Fickian diffusion from the non-soluble, non-swelling carriers. Using 3D printing in combination with the CPD process, we were able to develop dosage forms with individually tailored controlled drug release. The dissolution rate of our dosage forms can be easily adjusted to the individual needs by modifying the pore sizes of the 3D printed carriers.

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