Bifidobacterial Lacto-N-biose/Galacto-N-biose Pathway Involved in Intestinal Growth

2009 ◽  
pp. 113-121
Author(s):  
Mamoru Nishimoto ◽  
Motomitsu Kitaoka
Keyword(s):  
Intestinal Growth

A stitch in time saves nine: suture technique does not affect intestinal growth in a young, growing animal model

2016 ◽  
Vol 51 (5) ◽  
pp. 819-821
Author(s):  
Lori A. Gurien ◽  
Deidre L. Wyrick ◽  
Samuel D. Smith ◽  
R. Todd Maxson
Keyword(s):  
Animal Model ◽  
Suture Technique ◽  
Intestinal Growth

scholarly journals 109 Amino acids in intestinal growth and health.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 387-388 ◽  
Author(s):  
Y Hou
Keyword(s):  
Amino Acids ◽  
Intestinal Growth

scholarly journals Organ Growth and Intestinal Functions of Preterm Pigs Fed Low and High Protein Formulas With or Without Supplemental Leucine or Hydroxymethylbutyrate as Growth Promoters

2021 ◽  
Vol 8 ◽  
Author(s):  
Randal K. Buddington ◽  
Taisiya Yakimkova ◽  
Adebowale Adebiyi ◽  
Victor V. Chizhikov ◽  
Igor Y. Iskusnykh ◽  
...  
Keyword(s):  
Small Intestine ◽  
Birth Weight ◽  
Protein Level ◽  
Nutrition Support ◽  
Standards Of Care ◽  
Average Weight ◽  
Growth Promoter ◽  
Growth Promoters ◽  
Intestinal Growth ◽  
Organ Weights

The goal of enteral nutritional support for infants born preterm or small for gestational age (SGA) is to achieve normal growth and development. Yet, this is difficult to achieve because of intestinal immaturity. Our objective was to determine if birth weight, protein intake, and the growth promoters leucine (10 g/L) or calcium-ß-hydroxy-ß-methylbutryate (HMB; 1.1 g/L) would affect trajectories of intestinal growth and functions and weights of other organs. Preterm pigs were delivered at gestational day 105 (91% of term) and fed for 6 or 7 days isocaloric formulas that differed in protein content (50 g or 100 g protein/L), with and without the growth promoters leucine or HMB. For comparative purposes organ weights were measured within 12 h after delivery for six term pigs of low and six of average birth weights. The responses of intestinal growth and total intestinal brush border membrane carbohydrases to protein level and supplemental leucine were of greater magnitude for preterm pigs of lower birth weight. Forskolin stimulated chloride secretion in the proximal small intestine was lower for pigs fed the low protein milk replacers. Capacities of the entire small intestine to transport glucose (mmol/kg-day) were not responsive to protein level, leucine, or HMB, and did not differ between small and large pigs. Relative organ weights of the small and average weight term pigs were similar, but some differed from those of the preterm pigs suggesting preterm birth and the standards of care used for this study altered the trajectories of development for the intestine and other organs. Although leucine is an effective generalized growth promoter that enhances gut development of small preterm pigs, it does not mitigate compromised neurodevelopment. Our findings using preterm pigs as a relevant preclinical model indicate nutrition support strategies can influence development of some gastrointestinal tract characteristics and the growth of other organs.

Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats

1997 ◽  
Vol 273 (4) ◽  
pp. E815-E820 ◽  
Author(s):  
Kirk D. Fischer ◽  
Savita Dhanvantari ◽  
Daniel J. Drucker ◽  
Patricia L. Brubaker
Keyword(s):  
Experimental Diabetes ◽  
Plasma Concentrations ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Villus Height ◽  
Intestinal Growth ◽  
Glucagon Like Peptide ◽  
Small Intestinal ◽  
The Relationship ◽  
Intestinal Weight

Glucagon-like peptide 2 (GLP-2) has recently been identified as a novel intestinal growth factor. Because experimental diabetes is associated with bowel growth, we examined the relationship between GLP-2 and intestinal growth in rats made diabetic by streptozotocin (STZ) injection and treated with or without insulin for 3 wk. Ileal concentrations of the intestinal proglucagon-derived peptides, i.e., glicentin + oxyntomodulin, and GLPs 1 and 2, were increased by 57 ± 20% above those of controls in untreated STZ diabetes ( P < 0.05–0.001). Similar increases in plasma concentrations of glicentin + oxyntomodulin (77 ± 15% above controls, P < 0.01) and GLP-2 (91 ± 32% above controls, P < 0.05) were seen in untreated STZ diabetes. Both wet and dry small intestinal weight increased by 74 ± 20% above controls ( P < 0.01) in STZ diabetes, and macromolecular analysis indicated parallel increases in both protein ( P < 0.001) and lipid ( P < 0.05) content. Villus height ( P < 0.001) and crypt depth ( P < 0.01) were also increased in untreated diabetic rat intestine. Insulin therapy prevented the changes in plasma GLP-2 and intestinal mass seen in untreated STZ diabetes. Thus STZ diabetes is associated with both increased production of GLP-2 and enhanced bowel weight, thereby suggesting a role for GLP-2 in diabetes-associated bowel growth.

Epithelial Src homology region 2 domain–containing phosphatase‐1 restrains intestinal growth, secretory cell differentiation, and tumorigenesis

2017 ◽  
Vol 31 (8) ◽  
pp. 3512-3526 ◽  
Author(s):  
Caroline Leblanc ◽  
Marie‐Josée Langlois ◽  
Geneviève Coulombe ◽  
Vanessa Vaillancourt‐Lavigueur ◽  
Christine Jones ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Secretory Cell ◽  
Intestinal Growth ◽  
Homology Region ◽  
Src Homology
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