Protection Against Oxidative Stress by Chronic Administration of Coenzyme Q

2000 ◽  
pp. 219-226
Author(s):  
Maurizio Battino ◽  
Gian Paolo Littarru
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q ◽  
Chronic Administration

A Soccer Match’s Ability to Enhance Lymphocyte Capability to Produce ROS and Induce Oxidative Damage

2009 ◽  
Vol 19 (3) ◽  
pp. 243-258 ◽  
Author(s):  
Miguel David Ferrer ◽  
Pedro Tauler ◽  
Antoni Sureda ◽  
Pedro Pujol ◽  
Franchec Drobnic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Coenzyme Q ◽  
Training Period ◽  
Antioxidant Vitamin ◽  
Antioxidant Enzyme Activities ◽  
Double Blind ◽  
Soccer Match ◽  
Before And After ◽  
Soccer Training

Soccer-associated oxidative stress has barely been studied. The aims of this study were to establish the effect of a soccer training match and the effect of a diet supplementation with a multivitamin complex and coenzyme Q during 3 months of soccer training on the pro-oxidant and antioxidant status of lymphocytes. In a randomized, double-blind trial, 19 male preprofessional soccer players were treated with either an antioxidant nutrient cocktail or placebo for 90 days. After this period the athletes played a soccer match lasting 60 min. All determinations were made under basal conditions before and after the training period and after the match. Basal lymphocyte hydrogen peroxide (H2O2) production did not change after the 3 months of training. Catalase activity decreased (about 50%) after the 3 months, whereas glutathione reductase increased its activity (150–200%) both with placebo and in the supplemented group. Basal ascorbate levels were maintained during the training period, whereas α-tocopherol and MDA decreased (about 40%) in both groups. The match increased H2O2 production (180%) in both groups when the lymphocytes were stimulated with phorbol myristate acetate, and it also increased MDA levels (150%). Antioxidant enzyme activities and antioxidant vitamin levels were maintained before and after the match. Regular soccer training modifies the lymphocyte strategy to eliminate ROS and increases protection against oxidative damage. A friendly soccer match raises lymphocyte capacity to produce ROS and oxidative damage, but it is not enough to induce a defensive response, thus leading to a situation of postexercise oxidative stress. Supplementation with low doses of antioxidant vitamins and coenzyme Q does not modify the endogenous antioxidant response to training.

scholarly journals Preclinical Study on the Ameliorating Effect of L-Ascorbic Acid for the Oxidative Stress of Caused by Chronic Administration of Organic Nitrates in Cardiovascular Diseases

2021 ◽  
Author(s):  
Ahmed M Hamdan ◽  
Zuhair M. Mohammedsaleh ◽  
Aalaa Aboelnour ◽  
Sherif M.H. Elkhannishi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Chronic Administration ◽  
Stress Factors ◽  
Male Rats ◽  
Oxidative Stress Marker ◽  
Organic Nitrates ◽  
Dependent Manner ◽  
Dose Dependent

Abstract PurposeThe therapeutic activity of Glyceryl trinitrate (GTN) is mainly regulated by liberating nitric oxide (NO) and reactive nitrogen species (RNS). During this biotransformation, oxidative stress and lipid peroxidation inside the red blood cells (RBCs) occur. The principal objective of our research is to explain the ameliorating effect of L-ascorbic acid for the deleterious effects of chronic administration of nitrovasodilator drugs. MethodsWe studied some biochemical parameters for the oxidative stress using groups of high sucrose/fat (HSF) diet Wistar male rats chronically orally administered ISMN. Afterwards, we evaluated the role of L-ascorbic acid against these biochemical changes. ResultsChronic treatment with organic nitrates caused elevated serum levels of lipid peroxidation, hemoglobin derivatives as methemoglobin and carboxyhemoglobin, rate of hemoglobin autoxidation, the cellular levels of pro-inflammatory cytokines marker (NF-κB) and apoptosis markers (caspase-3) in myocardium muscles in a dose dependent manner. Meanwhile, such exposure caused decline in the enzymatic effect of superoxide dismutase (SOD), glutathione (GSH) and catalase activity (CAT) accompanied with a decrease of in the level of mitochondrial oxidative stress marker (nrf2) in myocardium muscles and decrease in the serum iron and total iron binding capacity (TIBC) in a dose dependent manner. Concomitant treatment with L-ascorbic acid significantly diminished these changes for all examined parameters.ConclusionChronic administration of organic nitrates leads to the alteration of the level of oxidative stress factors in the myocardium tissue due to generation of reactive oxygen species. Using vitamin C can effectively ameliorate such intoxication to overcome the nitrate tolerance.

Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats

2020 ◽  
Vol 57 (9) ◽  
pp. 3979-3988 ◽  
Author(s):  
Maricarmen Hernández-Rodríguez ◽  
Ivonne Maciel Arciniega-Martínez ◽  
Iohanan Daniel García-Marín ◽  
José Correa-Basurto ◽  
Martha Cecilia Rosales-Hernández
Keyword(s):  
Oxidative Stress ◽  
Amyloid Beta ◽  
Wistar Rats ◽  
Chronic Administration ◽  
Beta Secretase ◽  
And Oxidative Stress

scholarly journals Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges

2020 ◽  
Vol 2020 ◽  
pp. 1-20 ◽  
Author(s):  
Ana Paula Vargas Visentin ◽  
Rafael Colombo ◽  
Ellen Scotton ◽  
Débora Soligo Fracasso ◽  
Adriane Ribeiro da Rosa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Coenzyme Q ◽  
Antioxidant Defenses ◽  
Current Evidence ◽  
Stress Studies ◽  
Neuronal Membranes ◽  
Mitochondrial Membrane Depolarization ◽  
Depressive Patients ◽  
And Oxidative Stress

The prevalence of psychiatric disorders has increased in recent years. Among existing mental disorders, major depressive disorder (MDD) has emerged as one of the leading causes of disability worldwide, affecting individuals throughout their lives. Currently, MDD affects 15% of adults in the Americas. Over the past 50 years, pharmacotherapy, psychotherapy, and brain stimulation have been used to treat MDD. The most common approach is still pharmacotherapy; however, studies show that about 40% of patients are refractory to existing treatments. Although the monoamine hypothesis has been widely accepted as a molecular mechanism to explain the etiology of depression, its relationship with other biochemical phenomena remains only partially understood. This is the case of the link between MDD and inflammation, mitochondrial dysfunction, and oxidative stress. Studies have found that depressive patients usually exhibit altered inflammatory markers, mitochondrial membrane depolarization, oxidized mitochondrial DNA, and thus high levels of both central and peripheral reactive oxygen species (ROS). The effect of antidepressants on these events remains unclear. Nevertheless, the effects of ROS on the brain are well known, including lipid peroxidation of neuronal membranes, accumulation of peroxidation products in neurons, protein and DNA damage, reduced antioxidant defenses, apoptosis induction, and neuroinflammation. Antioxidants such as ascorbic acid, tocopherols, and coenzyme Q have shown promise in some depressive patients, but without consensus on their efficacy. Hence, this paper provides a review of MDD and its association with inflammation, mitochondrial dysfunction, and oxidative stress and is aimed at thoroughly discussing the putative links between these events, which may contribute to the design and development of new therapeutic approaches for patients.

scholarly journals Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr-/- Mice after Consumption of Guarana Soft Drinks

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Layla Aparecida Chisté ◽  
Beatriz Peters Pereira ◽  
Marcella Leite Porto ◽  
Jairo Pinto de Oliveira ◽  
Arícia Leone Evangelista Monteiro de Assis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Administration ◽  
Poor Quality ◽  
Soft Drinks ◽  
Free Sugar ◽  
Sugar Consumption ◽  
Atherosclerotic Lesions ◽  
Quality Diet ◽  
Excessive Consumption ◽  
Biochemical Analyses

Background. Excessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases. We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigating potential clinical confounders such as poor-quality diet, lifestyle, body composition, and/or comorbidities. Methods. Sixteen-month-old LDLr-/- mice were divided into the following groups: (1) control; (2) GSD: normal guarana SD; and (3) Z-GSD: zero guarana SD. All were fed ad libitum, and blood pressure was measured noninvasively. After 8 weeks, aorta, blood, liver, and stomach samples were collected for histological and biochemical analyses. Results. Guarana soft drinks increased atherosclerosis (~60%) and were associated with hypercholesterolemia, hypertension, oxidative stress, DNA fragmentation, and apoptosis (~2-fold) of blood cells, besides presenting an increase in liver and gastric damage even in normoglycemia. Interestingly, Z-GSD did not cause the aforementioned changes, except in hemodynamic and renal parameters. Conclusions. Chronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se.

scholarly journals Sub-chronic administration of brewed coffee on rat behavior and cognition and oxidative stress Alzheimer's disease model

2019 ◽  
Vol 28 ◽  
pp. 62-73 ◽  
Author(s):  
Gohar Sedaghat ◽  
Mohammad Ali Mirshekar ◽  
Mahsa Amirpour ◽  
Farzaneh Montazerifar ◽  
Somayeh Miri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Model ◽  
Chronic Administration ◽  
And Oxidative Stress ◽  
Behavior And Cognition

scholarly journals L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 793
Author(s):  
Cheng Schwank-Xu ◽  
Elisabete Forsberg ◽  
Magnus Bentinger ◽  
Allan Zhao ◽  
Ishrath Ansurudeen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
Mitochondrial Function ◽  
Diabetes Complications ◽  
Synergistic Effects ◽  
Coenzyme Q ◽  
Protective Effects ◽  
Beneficial Effects

Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of type 2 diabetes. Coenzyme Q (CoQ), a component of the mitochondrial electron transport chain, possesses similar protective effects on diabetes complications. We aimed to study the effect of carnosine on CoQ, and assess any synergistic effects of carnosine and CoQ on improved mitochondrial function in a mouse model of type 2 diabetes. Carnosine enhanced CoQ gene expression and increased hepatic CoQ biosynthesis in db/db mice, a type 2 diabetes model. Co-administration of Carnosine and CoQ improved mitochondrial function, lowered ROS formation and reduced signs of oxidative stress. Our work suggests that carnosine exerts beneficial effects on hepatic CoQ synthesis and when combined with CoQ, improves mitochondrial function and cellular redox balance in the liver of diabetic mice. (4) Conclusions: L-carnosine has beneficial effects on oxidative stress both alone and in combination with CoQ on hepatic mitochondrial function in an obese type 2 diabetes mouse model.

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