Exercise-Induced Oxidative Stress and Coenzyme Q

2000 ◽  
pp. 357-368
Author(s):  
Jerzy Faff
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q ◽  
Exercise Induced

scholarly journals Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10

2008 ◽  
Vol 100 (4) ◽  
pp. 903-909 ◽  
Author(s):  
Michihiro Kon ◽  
Kai Tanabe ◽  
Takayuki Akimoto ◽  
Fuminori Kimura ◽  
Yuko Tanimura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Placebo Group ◽  
Coenzyme Q ◽  
Lipid Peroxide ◽  
Experimental Period ◽  
Male Students ◽  
Double Blind ◽  
Muscular Injury ◽  
Exercise Induced ◽  
Blind Manner

Intensive physical exercise may cause muscular injury and increase oxidative stress. The purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10), on muscular injury and oxidative stress during exercise training. Eighteen male students, all elite Japanese kendo athletes, were randomly assigned to either a CoQ10 group (n 10) or a placebo group (n 8) in a double-blind manner. Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d, while subjects in the placebo group took the same dosage of a placebo. All subjects practised kendo 5·5 h per d for 6 d during the experimental period. Blood samples were taken 2 weeks before, during (1 d, 3 d, 5 d) and 1 week after the training. Serum creatine kinase (CK) activity and myoglobin (Mb) concentration significantly increased in both groups (at 3 d and 5 d). Serum CK (at 3 d), Mb (at 3 d) and lipid peroxide (at 3 d and 5 d) of the CoQ10 group were lower than those of the placebo group. The leucocyte counts in the placebo group significantly increased (at 3 d) and neutrophils significantly increased in both groups (at 3 d and 5 d). Serum scavenging activity against superoxide anion did not change in either group. These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes.

Quercetin Effects on Exercise Induced Oxidative Stress and Inflammation

2017 ◽  
Vol 21 (4) ◽  
pp. 348-356 ◽  
Author(s):  
Silvia Tejada ◽  
Seyed Nabavi ◽  
Xavier Capo ◽  
Miquel Martorell ◽  
Maria Bibiloni ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Induced

scholarly journals How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 153
Author(s):  
Aslı Devrim-Lanpir ◽  
Lee Hill ◽  
Beat Knechtle
Keyword(s):  
Oxidative Stress ◽  
Oxidative Metabolism ◽  
Adaptive Response ◽  
Redox Regulation ◽  
Therapeutic Agent ◽  
Metabolic Effects ◽  
Metabolic Adaptations ◽  
Current Perspective ◽  
Exercise Induced ◽  
Response To Exercise

Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.

scholarly journals Exercise‐Induced Oxidative Stress in Older Adults as a Function of Habitual Activity Level

2002 ◽  
Vol 50 (2) ◽  
pp. 349-353 ◽  
Author(s):  
Erwin P. Meijer ◽  
Annelies H. C. Goris ◽  
Joost L. J. Van Dongen ◽  
Aalt Bast ◽  
Klaas R. Westerterp
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Activity Level ◽  
Habitual Activity ◽  
Exercise Induced

Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of two randomised, clinical trials.

2021 ◽  
Author(s):  
Nanna Skytt Pilmark ◽  
Laura Oberholzer ◽  
Jens Frey Halling ◽  
Jonas M. Kristensen ◽  
Christina Pedersen Bønding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Human Skeletal Muscle ◽  
Acute Exercise ◽  
Metformin Treatment ◽  
Ampk Activation ◽  
Double Blind ◽  
Parallel Group ◽  
Exercise Induced

Metformin and exercise both improve glycemic control, but in vitro studies have indicated that an interaction between metformin and exercise occurs in skeletal muscle, suggesting a blunting effect of metformin on exercise training adaptations. Two studies (a double-blind, parallel-group, randomized clinical trial conducted in 29 glucose-intolerant individuals and a double-blind, cross-over trial conducted in 15 healthy lean males) were included in this paper. In both studies, the effect of acute exercise +/- metformin treatment on different skeletal muscle variables, previously suggested to be involved in a pharmaco-physiological interaction between metformin and exercise, was assessed. Furthermore, in the parallel-group trial, the effect of 12 weeks of exercise training was assessed. Skeletal muscle biopsies were obtained before and after acute exercise and 12 weeks of exercise training, and mitochondrial respiration, oxidative stress and AMPK activation was determined. Metformin did not significantly affect the effects of acute exercise or exercise training on mitochondrial respiration, oxidative stress or AMPK activation, indicating that the response to acute exercise and exercise training adaptations in skeletal muscle is not affected by metformin treatment. Further studies are needed to investigate whether an interaction between metformin and exercise is present in other tissues, e.g. the gut. Trial registration: ClinicalTrials.gov (NCT03316690 and NCT02951260). Novelty bullets • Metformin does not affect exercise-induced alterations in mitochondrial respiratory capacity in human skeletal muscle • Metformin does not affect exercise-induced alterations in systemic levels of oxidative stress nor emission of reactive oxygen species from human skeletal muscle • Metformin does not affect exercise-induced AMPK activation in human skeletal muscle

scholarly journals Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1875 ◽  
Author(s):  
Josefine Nebl ◽  
Kathrin Drabert ◽  
Sven Haufe ◽  
Paulina Wasserfurth ◽  
Julian Eigendorf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Amino Acid ◽  
Acute Exercise ◽  
Amino Acid Profile ◽  
Post Exercise ◽  
Stable Isotope Dilution ◽  
Amino Acid Profiles ◽  
Recreational Runners ◽  
Exercise Induced

This study investigated the exercise-induced changes in oxidative stress, nitric oxide (NO) metabolism and amino acid profile in plasma of omnivorous (OMN, n = 25), lacto-ovo-vegetarian (LOV, n = 25) and vegan (VEG, n = 23) recreational runners. Oxidative stress was measured as malondialdehyde (MDA), NO as nitrite and nitrate, and various amino acids, including homoarginine and guanidinoacetate, the precursor of creatine. All analytes were measured by validated stable-isotope dilution gas chromatographic-mass spectrometric methods. Pre-exercise, VEG had the highest MDA and nitrate concentrations, whereas nitrite concentration was highest in LOV. Amino acid profiles differed between the groups, with guanidinoacetate being highest in OMN. Upon acute exercise, MDA increased in the LOV and VEG group, whereas nitrate, nitrite and creatinine did not change. Amino acid profiles changed post-exercise in all groups, with the greatest changes being observed for alanine (+28% in OMN, +21% in LOV and +28% in VEG). Pre-exercise, OMN, LOV and VEG recreational runners differ with respect to oxidative stress, NO metabolism and amino acid profiles, in part due to their different dietary pattern. Exercise elicited different changes in oxidative stress with no changes in NO metabolism and closely comparable elevations in alanine. Guanidinoacetate seems to be differently utilized in OMN, LOV and VEG, pre- and post-exercise.

A Soccer Match’s Ability to Enhance Lymphocyte Capability to Produce ROS and Induce Oxidative Damage

2009 ◽  
Vol 19 (3) ◽  
pp. 243-258 ◽  
Author(s):  
Miguel David Ferrer ◽  
Pedro Tauler ◽  
Antoni Sureda ◽  
Pedro Pujol ◽  
Franchec Drobnic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Coenzyme Q ◽  
Training Period ◽  
Antioxidant Vitamin ◽  
Antioxidant Enzyme Activities ◽  
Double Blind ◽  
Soccer Match ◽  
Before And After ◽  
Soccer Training

Soccer-associated oxidative stress has barely been studied. The aims of this study were to establish the effect of a soccer training match and the effect of a diet supplementation with a multivitamin complex and coenzyme Q during 3 months of soccer training on the pro-oxidant and antioxidant status of lymphocytes. In a randomized, double-blind trial, 19 male preprofessional soccer players were treated with either an antioxidant nutrient cocktail or placebo for 90 days. After this period the athletes played a soccer match lasting 60 min. All determinations were made under basal conditions before and after the training period and after the match. Basal lymphocyte hydrogen peroxide (H2O2) production did not change after the 3 months of training. Catalase activity decreased (about 50%) after the 3 months, whereas glutathione reductase increased its activity (150–200%) both with placebo and in the supplemented group. Basal ascorbate levels were maintained during the training period, whereas α-tocopherol and MDA decreased (about 40%) in both groups. The match increased H2O2 production (180%) in both groups when the lymphocytes were stimulated with phorbol myristate acetate, and it also increased MDA levels (150%). Antioxidant enzyme activities and antioxidant vitamin levels were maintained before and after the match. Regular soccer training modifies the lymphocyte strategy to eliminate ROS and increases protection against oxidative damage. A friendly soccer match raises lymphocyte capacity to produce ROS and oxidative damage, but it is not enough to induce a defensive response, thus leading to a situation of postexercise oxidative stress. Supplementation with low doses of antioxidant vitamins and coenzyme Q does not modify the endogenous antioxidant response to training.

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