The Role of Coenzyme Q In Lysomes

Coenzyme Q ◽  
2000 ◽  
pp. 115-124
Keyword(s):  
Coenzyme Q

A critical appraisal of the role of respiratory supercomplexes in mitochondria

2013 ◽  
Vol 394 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Maria Luisa Genova ◽  
Giorgio Lenaz
Keyword(s):  
Critical Appraisal ◽  
Dynamic Equilibrium ◽  
Coenzyme Q ◽  
Mitochondrial Respiratory Chain ◽  
Substantial Evidence ◽  
Mammalian Mitochondria ◽  
Respiratory Supercomplexes ◽  
Functional Relevance ◽  
The Individual

Abstract Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies have focused on their functional relevance. Although the presence of coenzyme Q channeling between complexes I and III has been ascertained, no such clear demonstration has been carried out for cytochrome c between complexes III and IV, at least in mammalian mitochondria. This review also discusses the implications concerning the number of respiratory complexes organized in supercomplexes and the possibility that they represent associations in dynamic equilibrium with the individual complexes.

The role of Coenzyme Q in mitochondrial electron transport

Mitochondrion ◽  
2007 ◽  
Vol 7 ◽  
pp. S8-S33 ◽  
Author(s):  
Giorgio Lenaz ◽  
Romana Fato ◽  
Gabriella Formiggini ◽  
Maria Luisa Genova
Keyword(s):  
Electron Transport ◽  
Coenzyme Q

Protective Role of Melatonin and Coenzyme Q10 in Ochratoxin A Toxicity in Rat Liver and Kidney

2007 ◽  
Vol 26 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Emine Sutken ◽  
Erinc Aral ◽  
Filiz Ozdemir ◽  
Sema Uslu ◽  
Ozkan Alatas ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ochratoxin A ◽  
Coenzyme Q ◽  
Kidney Tissue ◽  
Treated Group ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Liver And Kidney

Melatonin (MEL) and coenzyme Q10 (CoQ10) both display antioxidant and free radical scavenger properties. In the present study, the effect of MEL and CoQ10 on the oxidative stress and fibrosis induced by ochratoxin A (OTA) administration in rats was investigated. Rats were divided into five equal groups, each consisting of seven rats: (1) controls; (2) OTA-treated rats (289 μg/kg/day); (3) OTA+MEL–treated rats (289 μg/kg/day OTA + 10 mg/kg/day MEL); and (4) OTA+CoQ10–treated rats (289 μg/kg/day OTA +1 mg/100 g/day body weight (bw) CoQ10). After 4 weeks of treatment, the level of malondialdehyde (MDA), glutathione peroxidase (GPx), and hydroxyproline (Hyp) were measured in the homogenates of liver and kidney. In the OTA-treated group, the levels of MDA and Hyp in both liver and kidney were significantly increased when compared with the levels of control, whereas GPx activities decreased. In OTA+MEL–treated rats, the levels of MDA and Hyp in both liver and kidney were significantly decreased when compared with the levels of OTA-treated rats; however; GPX activities increased. In the OTA+CoQ10–treated group, the levels of MDA and Hyp were decreased when compared with the levels of OTA-treated rats, whereas GPx activities increased. In the OTA+CoQ 10–treated group, the levels of MDA, Hyp, and GPx were not significantly changed in kidney when compared with OTA-treated group. MEL has a protective effect against OTA toxicity through an inhibition of the oxidative damage and fibrosis both liver and kidney. Although CoQ10 has protective effect against OTA toxicity in liver tissue, it has no effect in kidney tissue.

On the role of coenzyme Q in electron transport

1959 ◽  
Vol 1 (2) ◽  
pp. 45-48 ◽  
Author(s):  
D.E. Green ◽  
Youssef Hatefi ◽  
W.F. Fechner
Keyword(s):  
Electron Transport ◽  
Coenzyme Q

scholarly journals Biochemical Alterations in Semen of Varicocele Patients: A Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Antonio Mancini ◽  
Roberto Festa ◽  
Sebastiano Raimondo ◽  
Andrea Silvestrini ◽  
Elena Giacchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Surgical Treatment ◽  
Molecular Mechanisms ◽  
Coenzyme Q ◽  
Published Data ◽  
Sperm Cells ◽  
Review Of The Literature ◽  
Biochemical Alterations ◽  
Biochemical Abnormalities

Oxidative stress is a mechanism underlying different kinds of infertility in human males. However, different results can be observed in relation to the method used for its evaluation. Varicocele patients show a number of biochemical abnormalities, including an altered distribution of coenzyme Q between seminal plasma and sperm cells and also an apparent defect in the utilization of antioxidants. Moreover, an influence of systemic hormones on seminal antioxidant system was observed too. Finally, the effects of surgical treatment on oxidativestress indexes and the possible usefulness of some medical therapies, like coenzyme Q supplementation, are discussed. In conclusion, published data show a role of oxidative stress in varicocele-related male infertility, but at present we do not know the precise molecular mechanisms underlying these phenomena.

scholarly journals Potential role of coenzyme Q10 in health and disease conditions

2018 ◽  
Vol Volume 10 ◽  
pp. 1-11 ◽  
Author(s):  
Taylor C Rodick ◽  
Donna R Seibels ◽  
Jeganathan Ramesh Babu ◽  
Kevin W Huggins ◽  
Guang Ren ◽  
...  
Keyword(s):  
Potential Role ◽  
Coenzyme Q ◽  
Health And Disease
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