Basic Cell Biology and Molecular Genetics

2007 ◽  
pp. 53-82
Keyword(s):  
Molecular Genetics ◽  
Cell Biology ◽  
Basic Cell

Introduction

1978 ◽  
Vol 36 (3) ◽  
pp. 543-544
Author(s):  
W. Bernard
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Nucleic Acid ◽  
Gene Mapping ◽  
Molecular Genetics ◽  
Cell Biology ◽  
Gene Activity ◽  
Close Connection ◽  
Basic Information ◽  
Simple Systems

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

Toxoplasma as a Model Apicomplexan Parasite: Biochemistry, Cell Biology, Molecular Genetics, Genomics and Beyond

2000 ◽  
pp. 143-167 ◽  
Author(s):  
David S. Roos ◽  
John A. Darling ◽  
Mary G. Reynolds ◽  
Kristin M. Hager ◽  
Boris Striepen ◽  
...  
Keyword(s):  
Molecular Genetics ◽  
Cell Biology ◽  
Apicomplexan Parasite

Basic Cell Biology

2020 ◽  
pp. 9-23
Author(s):  
Kedar N. Prasad
Keyword(s):  
Cell Biology ◽  
Basic Cell

Basic cell biology

2013 ◽  
pp. 75-98
Author(s):  
Lesley H. Greene ◽  
Gilbert Shama
Keyword(s):  
Cell Biology ◽  
Basic Cell

scholarly journals The cell biological basis of ciliary disease

2008 ◽  
Vol 180 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Wallace F. Marshall
Keyword(s):  
Broad Spectrum ◽  
Cell Biology ◽  
Model Organisms ◽  
Small Subset ◽  
Disease Symptoms ◽  
Multiple Functions ◽  
Biological Basis ◽  
Basic Cell ◽  
Biological Studies ◽  
Clinical Complexity

Defects in cilia cause a broad spectrum of human diseases known collectively as the ciliopathies. Although all ciliopathies arise from defective cilia, the range of symptoms can vary significantly, and only a small subset of the possible ciliary disease symptoms may be present in any given syndrome. This complexity is puzzling until one realizes that the cilia are themselves exceedingly complex machines that perform multiple functions simultaneously, such that breaking one piece of the machine can leave some functions intact while destroying others. The clinical complexity of the ciliopathies can therefore only be understood in light of the basic cell biology of the cilia themselves, which I will discuss from the viewpoint of cell biological studies in model organisms.

The Wellcome Trust Lecture

Parasitology ◽  
1989 ◽  
Vol 98 (S1) ◽  
pp. S19-S28 ◽  
Author(s):  
G. F. Mitchell
Keyword(s):  
Infectious Disease ◽  
Molecular Genetics ◽  
Cell Biology ◽  
Helminth Parasite ◽  
Rural Poor ◽  
Modern Biology ◽  
Molecular Analyses ◽  
Human Parasite ◽  
State Of Affairs ◽  
Developed World

AbstractThe modern biology era in which molecular analyses dominate and immunology, cell biology and molecular genetics are prominent, has created unprecedented opportunities for the vaccine developer. The need for new and improved vaccines against many infectious disease agents is also great, no more so than for the protozoan and helminth parasite scourges of the rural poor in the tropical, less-industrially developed world. Despite the opportunities and needs, no vaccine against any human parasite yet exists nor does any molecular vaccine against any parasite; this chapter is a general discussion on the reasons for this state of affairs that assuredly will change soon.

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