Nanosuspensions for Parenteral Delivery

2007 ◽  
pp. 33-49 ◽  
Author(s):  
Barrett E. Rabinow
Keyword(s):  
Parenteral Delivery

scholarly journals Parenteral Delivery of HPβCD: Effects on Drug-HSA Binding

2010 ◽  
Vol 11 (3) ◽  
pp. 1152-1158 ◽  
Author(s):  
Sergey V. Kurkov ◽  
Thorsteinn Loftsson ◽  
Martin Messner ◽  
Donna Madden
Keyword(s):  
Parenteral Delivery

scholarly journals Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 855 ◽  
Author(s):  
Shakthi Apsara Thejani Opatha ◽  
Varin Titapiwatanakun ◽  
Romchat Chutoprapat
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems ◽  
Transdermal Administration ◽  
Factors Affecting ◽  
Molecular Weights ◽  
Parenteral Delivery ◽  
Amphiphilic Drug ◽  
Bilayered Structure ◽  
Pass Through ◽  
Improve Patient

Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the therapeutic agents. The greatest challenge of transdermal delivery systems is the barrier function of the skin’s outermost layer. Molecules with molecular weights greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, only a limited number of drugs are capable of being administered by this route. Encapsulating the drugs in transfersomes are one of the potential approaches to overcome this problem. They have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic, as well as amphiphilic, drug with higher permeation efficiencies compared to conventional liposomes. Transfersomes are elastic in nature, which can deform and squeeze themselves as an intact vesicle through narrow pores that are significantly smaller than its size. This review aims to describe the concept of transfersomes, the mechanism of action, different methods of preparation and characterization and factors affecting the properties of transfersomes, along with their recent applications in the transdermal administration of drugs.

First report on the efficacy of l-alanine-based in situ-forming implants for the long-term parenteral delivery of drugs

2005 ◽  
Vol 108 (2-3) ◽  
pp. 433-441 ◽  
Author(s):  
François Plourde ◽  
Aude Motulsky ◽  
Anne-Claude Couffin-Hoarau ◽  
Didier Hoarau ◽  
Huy Ong ◽  
...  
Keyword(s):  
First Report ◽  
Parenteral Delivery ◽  
In Situ Forming ◽  
In Situ Forming Implants

Parenteral Delivery of Peptides and Proteins

2011 ◽  
pp. 531-622 ◽  
Author(s):  
Himanshu Agrawal ◽  
Nipa Thacker ◽  
Ambikanandan Misra
Keyword(s):  
Parenteral Delivery

scholarly journals Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1184
Author(s):  
Alam Zeb ◽  
Isra Rana ◽  
Ho-Ik Choi ◽  
Cheol-Ho Lee ◽  
Seong-Woong Baek ◽  
...  
Keyword(s):  
Viable Option ◽  
Commercial Success ◽  
Drug Products ◽  
The Past ◽  
Small Molecule Drug ◽  
Parenteral Delivery ◽  
Pathological Conditions ◽  
Efficient Delivery ◽  
Intracellular Targets ◽  
Plasma Half Life

During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products. These advantages include better specificity, potency, targeting abilities, and reduced side effects. Despite the substantial clinical and commercial success, the macromolecular structure and intrinsic instability of biopharmaceuticals make their formulation and administration challenging and render parenteral delivery as the only viable option in most cases. The use of nanocarriers for efficient delivery of biopharmaceuticals is essential due to their practical benefits such as protecting from degradation in a hostile physiological environment, enhancing plasma half-life and retention time, facilitating absorption through the epithelium, providing site-specific delivery, and improving access to intracellular targets. In the current review, we highlight the clinical and commercial success of biopharmaceuticals and the overall applications and potential of nanocarriers in biopharmaceuticals delivery. Effective applications of nanocarriers for biopharmaceuticals delivery via invasive and noninvasive routes (oral, pulmonary, nasal, and skin) are presented here. The presented data undoubtedly demonstrate the great potential of combining nanocarriers with biopharmaceuticals to improve healthcare products in the future clinical landscape. In conclusion, nanocarriers are promising delivery tool for the hormones, cytokines, nucleic acids, vaccines, antibodies, enzymes, and gene- and cell-based therapeutics for the treatment of multiple pathological conditions.

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