Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals

2007 ◽  
pp. 215-228
Keyword(s):  
Single Dose ◽  
Companion Animals ◽  
Long Acting

scholarly journals Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

2018 ◽  
Vol 115 (29) ◽  
pp. E6920-E6926 ◽  
Author(s):  
Marie Miglianico ◽  
Maarten Eldering ◽  
Hannah Slater ◽  
Neil Ferguson ◽  
Pauline Ambrose ◽  
...  
Keyword(s):  
Single Dose ◽  
Allometric Scaling ◽  
Disease Incidence ◽  
Companion Animals ◽  
Sand Flies ◽  
Median Dose ◽  
Preclinical Pharmacokinetics ◽  
Insecticidal Effect ◽  
Regional Population ◽  
Vector Borne

Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Aedes, and Culex mosquitoes and Phlebotomus sand flies after feeding on a drug-supplemented blood meal, with IC50 values ranging from 33 to 575 nM, and were fully active against strains with preexisting resistance to common insecticides. Based on allometric scaling of preclinical pharmacokinetics data, we predict that a single human median dose of 260 mg (IQR, 177–407 mg) for afoxolaner, or 410 mg (IQR, 278–648 mg) for fluralaner, could provide an insecticidal effect lasting 50–90 days against mosquitoes and Phlebotomus sand flies. Computational modeling showed that seasonal mass drug administration of such a single dose to a fraction of a regional population would dramatically reduce clinical cases of Zika and malaria in endemic settings. Isoxazolines therefore represent a promising new component of drug-based vector control.

ANABOLIC STEROID AND INTRAPULMONARY HEPARIN IN THE PREVENTION OF POSTOPERATIVE DEEP VEIN THROMBOSIS

1987 ◽  
Author(s):  
K Zawilska ◽  
A Tokarz ◽  
P Psuja ◽  
P Szymczak ◽  
S Kawczyński ◽  
...  
Keyword(s):  
Body Weight ◽  
Deep Vein Thrombosis ◽  
Single Dose ◽  
Anabolic Steroid ◽  
Group Iii ◽  
Vein Thrombosis ◽  
Group I ◽  
Group Ii ◽  
Long Acting ◽  
Deep Vein

150 patients over 40 years old undergoing major abdominal surgery were divided into 3 groups:1/ group I - receiving a single injection of long acting anabolic steroid /nandrolone phenylpropio-nate, 50 mg intramusculary/ a day prior to surgery 2/ gropup II - receiving the same dose of anabolic steroid plus a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery 3/ group III - receiving only a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery.The deep vein thrombosis /DVT/ was detected using the 125 I-fibrinogen test. The occurence of DVT was:in group I - 14%in group II - 4%in group III - 8%There were no detectable haemorrhagic complications in patients of group I and III, in 6% of patients of group II a sgliht increase of intraoperative bleeding and/or wound hematoma appeared.We conclude that prophylaxis of DVT in the postoperative period with the single dose of anabolic steroid and intrapulmonary heparin is an effective, safe and easy to handle procedure.

Progestin treatment in the dog II. Effects on the hypothalamic–pituitary–adrenocortical axis

1994 ◽  
Vol 131 (4) ◽  
pp. 422-430 ◽  
Author(s):  
PJ Selman ◽  
JA Mol ◽  
GR Rutteman ◽  
A Rijnberk
Keyword(s):  
The Netherlands ◽  
Hpa Axis ◽  
Medroxyprogesterone Acetate ◽  
Companion Animals ◽  
Creatinine Ratio ◽  
Basal Cortisol ◽  
Progestin Treatment ◽  
Cortisol Levels ◽  
Long Acting ◽  
Time Of Administration

Selman PJ, Mol JA, Rutteman GR, Rijnberk A. Progestin treatment in the dog. II. Effects on the hypothalamic–pituitary–adrenocortical axis. Eur J Endocrinol 1994;131:422–30. ISSN 0804–4643 The effects of two synthetic progestins, medroxyprogesterone acetate (MPA) and proligestone (PROL), on the hypothalamic–pituitary–adrenocortical (HPA) axis were studied in two groups of eight ovariohysterectomized dogs each. Eight injections of long-acting progestins were administered at 3-week intervals. Recovery of the HPA axis was studied in four dogs of each group in the following 6 months. Basal levels of adrenocorticotrophin (ACTH) and cortisol in plasma and the urinary corticoid/creatinine ratio were measured. The responsiveness of the HPA axis was investigated by stimulation with ovine corticotrophin-releasing hormone. Both MPA and PROL caused sawtooth patterns of supression of basal ACTH and cortisol levels in plasma, synchronous with the time of administration. The suppression of the adrenocortical component of the HPA axis was most pronounced. Adrenocorticotrophin production also was affected but to a lesser extent and occurred especially in PROL-treated dogs. Soon after the cessation of progestin administration ACTH levels increased, sometimes with a rebound. In both groups basal cortisol levels and urinary corticoid/creatinine ratios did not return to pretreatment levels until 6 months after the last progestin injection. It is concluded that MPA and PROL act as glucocorticoid agonists and suppress the HPA axis. The suppression at the adrenocortical level may last for 6 months. JA Mol, Department of Clinical Sciences of Companion Animals, Utrecht University, PO Box 80.154, 3508 TD Utrecht, The Netherlands

scholarly journals Impact of multiple-dose versus single-dose inhaler devices on COPD patients’ persistence with long-acting β2-agonists: a dispensing database analysis

2014 ◽  
Vol 24 (1) ◽  
Author(s):  
Job FM van Boven ◽  
Joost J van Raaij ◽  
Ruben van der Galiën ◽  
Maarten J Postma ◽  
Thys van der Molen ◽  
...  
Keyword(s):  
Single Dose ◽  
Multiple Dose ◽  
Dose Inhaler ◽  
Database Analysis ◽  
Copd Patients ◽  
Long Acting ◽  
Inhaler Devices ◽  
Β2 Agonists
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