Deconvolution of Medical Images from Microscopic to Whole Body Images

2017 ◽  
pp. 193-262
Keyword(s):  
Medical Images ◽  
Whole Body ◽  
Body Images

scholarly journals A Multi-Channel Uncertainty-Aware Multi-Resolution Network for MR to CT Synthesis

2021 ◽  
Vol 11 (4) ◽  
pp. 1667
Author(s):  
Kerstin Klaser ◽  
Pedro Borges ◽  
Richard Shaw ◽  
Marta Ranzini ◽  
Marc Modat ◽  
...  
Keyword(s):  
Medical Image Analysis ◽  
Absolute Error ◽  
Magnetic Resonance Images ◽  
The Body ◽  
Whole Body ◽  
Image Size ◽  
Body Images ◽  
Image Translation ◽  
The Mean ◽  
Synthetic Ct

Synthesising computed tomography (CT) images from magnetic resonance images (MRI) plays an important role in the field of medical image analysis, both for quantification and diagnostic purposes. Convolutional neural networks (CNNs) have achieved state-of-the-art results in image-to-image translation for brain applications. However, synthesising whole-body images remains largely uncharted territory, involving many challenges, including large image size and limited field of view, complex spatial context, and anatomical differences between images acquired at different times. We propose the use of an uncertainty-aware multi-channel multi-resolution 3D cascade network specifically aiming for whole-body MR to CT synthesis. The Mean Absolute Error on the synthetic CT generated with the MultiResunc network (73.90 HU) is compared to multiple baseline CNNs like 3D U-Net (92.89 HU), HighRes3DNet (89.05 HU) and deep boosted regression (77.58 HU) and shows superior synthesis performance. We ultimately exploit the extrapolation properties of the MultiRes networks on sub-regions of the body.

scholarly journals Labeling of Salmonella Typhymurium with iodine-131 to study phagocytic function in rats

1989 ◽  
Vol 31 (3) ◽  
pp. 135-138
Author(s):  
Maria K. Sato ◽  
Aldo J. Rodrigues Junior ◽  
Edwaldo E. Camargo
Keyword(s):  
Whole Body ◽  
Large Field ◽  
Scintillation Camera ◽  
Functional Evaluation ◽  
Body Images ◽  
System A ◽  
Carrier Free ◽  
Free Iodine ◽  
Iodine 131 ◽  
Reticulo Endothelial System

The present study describes a method for labeling Salmonella typhymurium with iodine-131 to evaluate both the morphological and the functional characteristics of the reticulo-endothelial system. A suspension containing 2 x 10(9) bacteria per ml was labeled with carrier-free Na131I without reductor, with a labeling yield of 46.5 ± 3% and 3.5 ± 1.3% of free Iodine-131. The biodistribution of the labeled bacteria in rats was studied with a large field-of-view scintillation camera equiped with a pinhole collimator. Whole body images were obtained 15 and 30 minutes after intravenous injection of the labeled microorganisms. Images showed accumulation of bacteria in the liver and both normal and transplanted spleens of the animals. Autoradiographs of liver and spleen demonstrated labeled bacteria within the cells of the reticulo-endothelial system. The method described is easy to perform, has a good labeling yield and allows the functional evaluation of the reticulo-monophagocytic system, including transplanted spleens.

scholarly journals Bone metastasis classification using whole body images from prostate cancer patients based on convolutional neural networks application

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237213 ◽  
Author(s):  
Nikolaos Papandrianos ◽  
Elpiniki Papageorgiou ◽  
Athanasios Anagnostis ◽  
Konstantinos Papageorgiou
Keyword(s):  
Prostate Cancer ◽  
Neural Networks ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Convolutional Neural Networks ◽  
Whole Body ◽  
Body Images

scholarly journals Visual Body Part Representation in the Lateral Occipitotemporal Cortex in Children/Adolescents and Adults

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Yuko Okamoto ◽  
Ryo Kitada ◽  
Takanori Kochiyama ◽  
Hiroaki Naruse ◽  
Kai Makita ◽  
...  
Keyword(s):  
Univariate Analysis ◽  
Age Groups ◽  
Body Representation ◽  
Body Part ◽  
Autism Spectrum ◽  
Whole Body ◽  
Body Parts ◽  
Body Images ◽  
Adolescents And Adults ◽  
Occipitotemporal Cortex

Abstract The lateral occipitotemporal cortex (LOTC) that responds to human bodies and body parts has been implicated in social development and neurodevelopmental disorders like autism spectrum disorder (ASD). Neuroimaging studies using a representational similarity analysis (RSA) revealed that body representation in the LOTC of typically developing (TD) adults is categorized into 3 clusters: action effector body parts, noneffector body parts, and face parts. However, its organization of younger people (i.e., children and adolescents) and its association with individual traits remain unclear. In this functional MRI study, TD adults and children/adolescents observed photographs of hands, feet, arms, legs, chests, waists, upper/lower faces, the whole body, and chairs. The univariate analysis showed that fewer child/adolescent participants showed left LOTC activation in response to whole-body images (relative to those of chairs) than adult participants. Contrastingly, the RSA on both age groups revealed a comparable body representation with 3 clusters of body parts in the bilateral LOTC. Hence, this result indicates that, although response to whole-body images can differ, LOTC body part representations for children/ adolescents and adults are highly similar. Furthermore, sensory atypicality is associated with spatial LOTC organization, suggesting the importance of this region for understanding individual difference, which is frequently observed in ASD.

The Use of Magnetic Resonance Imaging to Estimate the Mass of the Pectoralis Muscle of Chickens In Vivo

1994 ◽  
Vol 1994 ◽  
pp. 50-50
Author(s):  
N.D. Scollan ◽  
L.J. Caston ◽  
Z. Liu ◽  
A.K. Zubair ◽  
S. Leeson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Broiler Chickens ◽  
Animal Studies ◽  
Whole Body ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Body Images ◽  
Tissue Samples

In studies of animal growth it is often necessary to assess whole body composition or organ size prior to and during the course of a particular treatment. Nuclear Magnetic Resonance (NMR) offers the possibility to achieve these measurements on the same animal and in a non-invasive fashion. The use of NMR in attaining body images, referred to as Magnetic Resonance Imaging (MRI), has developed as the imaging method of choice for humans, due to its excellent soft tissue contrast and use of nonionizing radiation. The use of NMR in animal studies has been limited, which is probably related to the availability of suitable facilities and the cost of using them. However, several research groups have applied it to determining fat and water content of tissue samples and intact animals (Mitchell et al., 1991; Scollan et al., 1993). The aim of this study was to evaluate the use of MRI to determine the size (volume) and shape of the Pectoralis muscle (Pectoralis major and minor) in broiler chickens, non-invasively and in vivo.

A three-dimensional registration method for automated fusion of micro PET-CT-SPECT whole-body images

2005 ◽  
Vol 24 (7) ◽  
pp. 886-893 ◽  
Author(s):  
Meei-Ling Jan ◽  
Keh-Shih Chuang ◽  
Guo-Wei Chen ◽  
Yu-Ching Ni ◽  
S. Chen ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Whole Body ◽  
Body Images ◽  
Registration Method ◽  
Pet Ct

Spect imaging of the serotonin transporter using a novel ligand - 123-I mZIENT - in human subjects - a dosimetry and biodisortribution study

2011 ◽  
Vol 26 (S2) ◽  
pp. 935-935
Author(s):  
R. Krishnadas ◽  
A. Nicol ◽  
S. Champion ◽  
S. Pimlott ◽  
J. Stehouwer ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Gamma Camera ◽  
Human Subjects ◽  
The Body ◽  
Whole Body ◽  
Body Images ◽  
Promising Agent ◽  
Regional Brain ◽  
The Brain ◽  
Spect Images

Levels of serotonin in the body are regulated by the serotonin transporters (SERT), which are predominantly located on the presynaptic terminals of serotonin-containing neurons. Alterations in the density of SERT have been implicated in the pathophysiology of many neuropsychiatric disorders.AimTo evaluate 123-I mZIENT (2(S)-[(S)-2b-carbomethoxy-3b-[3′-((Z)-2-iodoethenyl)phenyl]nortropane), a novel radiopharmaceutical for imaging SERT. The bio-distribution of the radiopharmaceutical in humans was investigated and dosimetry performed.MethodsThe study includes three healthy volunteers and three patients receiving SSRIs. Whole body images obtained on a gamma camera at 10 minutes, 1, 2, 3, 6, 24 and 48 hours post administration. Dosimetry was performed. ROIs were drawn over the brain, heart, kidneys, liver, lungs, salivary glands, spleen, thyroid and intestines. Blood was sampled at 5, 15, & 30 minutes and 1, 2, 3, 6, 24 and 48 hours post administration. Urine was collected at 1, 2, 3, 4, 6, 24 and 48 hours. Brain SPECT images were obtained using a neuroSPECT scanner at 4 hours, evaluated visually and analysed using ROI analysis.ResultsHigh quality SPECT images can be obtained after 100–150 MBq 123-ImZEINT. Regional brain uptake was observed in midbrain and basal ganglia in healthy volunteers, consistent with the known distribution of SERT. Biodistribution images demonstrated highest uptake in the lungs, brain, liver and intestines. The effective dose was within range of other commonly used ligands and is acceptable for clinical imaging.Conclusion123-ImZIENT is a promising agent for imaging SERT in humans with acceptable dosimetry.

Enhancement of Tumor Contrast on Radioimmunoscans by Using Mixtures of Monoclonal Antibody F(ab’)2 Fragments

1986 ◽  
Vol 25 (06) ◽  
pp. 216-219 ◽  
Author(s):  
A. Alavi ◽  
H. Koprowski ◽  
D. Herlyn ◽  
D. L. Munz
Keyword(s):  
Monoclonal Antibody ◽  
Gastrointestinal Tract ◽  
Nude Mice ◽  
Half Life ◽  
The Body ◽  
Whole Body ◽  
Antigenic Determinants ◽  
Body Images ◽  
Biological Half Life ◽  
Adenocarcinoma Cells

F(ab’)2 fragments of MAbs GA 73-3 (IgG 2a) and CO 29.11 (IgG 1), which detect distinct antigenic determinants on adenocarcinoma cells of the gastrointestinal tract, were labeled with 131I using the iodogen method. 41 nude mice bearing SW-948 CRC tumors were injected either with a mixture of 100 ¼Ci (11 ¼g) each (n = 9) of the two 131l-F(ab’)2 fragments or with either fragment alone at various doses (each group consisting of 8 mice): GA 73-3,100 ¼Ci (11 ¼g) and 200 ¼Ci (25 ¼g); CO 29.11,100 ¼Ci (11 ¼g) and 200 ¼Ci (26 ¼g). Whole-body images of the mice were obtained daily for up to six days after injection. Ratios of cpm/pixel in the tumor to those in the rest of the body (rob), representing tumor contrast, were significantly (p <0.05) higher in the group of mice injected with the mixture (3.9 ± 1.5) as compared to those given 100 or 200 jiCi of either fragment separately. The biological half-life (T1/2 biol) of the mixture (44.7 ± 14.5 h) in the CRC tumors was significantly (p <0.05) longer than T1/2 biol determined in the groups given either fragment alone. Tv bioL in the rob was similar in all groups of mice examined.

Sign in / Sign up

Export Citation Format

Share Document