Galectin-3 and Cancer

2008 ◽  
pp. 217-228
Keyword(s):  
Galectin 3

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Hostile attribution is associated with increased galectin-3 in heart failure patients

2013 ◽  
Author(s):  
Wawrzyniak Andrew J. ◽  
Kerry S. Whittaker ◽  
Sarah M. Godoy ◽  
Kristie M. Harris ◽  
Maria N. Banis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hostile Attribution ◽  
Heart Failure Patients ◽  
Galectin 3

Galectin-3 vermindert die akute und chronische DSS-Kolitis bei Mäusen

2008 ◽  
Vol 46 (10) ◽  
Author(s):  
E Lippert ◽  
M Stieber-Gunckel ◽  
C Hofmann ◽  
N Dunger ◽  
W Falk ◽  
...  
Keyword(s):  
Galectin 3

Galectin-3 and Aldosterone as Potential Tandem Biomarkers in Pulmonary Arterial Hypertension

2016 ◽  
Vol 64 (S 02) ◽  
Author(s):  
L. Calvier ◽  
E. Legchenko ◽  
L. Grimm ◽  
H. Sallmon ◽  
A. Hatch ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Galectin 3 ◽  
Pulmonary Arterial

Evaluation der kardialen Biomarker Galectin-3 und ST2 (IL1RL1) bei Patienten mit beginnender degenerativer Mitralklappenerkrankung (CHIEF B)

2019 ◽  
Author(s):  
S. Klein ◽  
I. Nolte ◽  
E.-M. Packeiser ◽  
N. Iwanuk ◽  
K. Rumstedt ◽  
...  
Keyword(s):  
Galectin 3

Galectin–3 wird in Fisteln, Stenosen und Makrophagen bei Morbus Crohn vermindert exprimiert

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
E Lippert ◽  
F Bataille ◽  
M Hausmann ◽  
S Kellermeier ◽  
W Falk ◽  
...  
Keyword(s):  
Morbus Crohn ◽  
Galectin 3

Galectin-3 induziert die Migration intestinaler Fibroblasten

2006 ◽  
Vol 44 (08) ◽  
Author(s):  
E Lippert ◽  
J Brenmoehl ◽  
W Falk ◽  
J Schölmerich ◽  
G Rogler
Keyword(s):  
Galectin 3

Galectin-3 in Heart Failure – Linking Fibrosis, Remodelling and Progression

2010 ◽  
Vol 6 (2) ◽  
pp. 33 ◽  
Author(s):  
Christopher R deFilippi ◽  
G Michael Felker ◽  
◽  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Risk Stratification ◽  
Cardiac Fibrosis ◽  
The Elderly ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients ◽  
Large Populations ◽  
Galectin 3

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

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