High-Throughput Solid-Phase Synthesis of Nucleoside- Based Libraries in the Search for New Antibiotics

2008 ◽  
pp. 215-238 ◽  
Author(s):  
Dianqing Sun ◽  
Richard Lee
Keyword(s):  
High Throughput ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
New Antibiotics

Approaches to the High-Throughput Synthesis of Analogues of Dihydroaeruginoic Acid

2000 ◽  
Vol 53 (6) ◽  
pp. 457 ◽  
Author(s):  
Wendy A. Loughlin ◽  
Scott A. Knevitt ◽  
Rachel E. Hosking ◽  
Raymond L. Marshall
Keyword(s):  
High Throughput ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

A solution-phase synthesis of dihydroaeruginoic acid (1) was identified for its application towards the high-throughput synthesis of analogues of dihydroaeruginoic acid (1). Development of a solid-phase synthesis of dihydroaeruginoic acid (1) was examined. Simple analogues (11a–f) of dihydroaeruginoic acid (1) were obtained by using solution-phase high-throughput synthesis.

scholarly journals A New Approach to Automated Solid Phase Synthesis Based on Centrifugation of Tilted Plates

1998 ◽  
Vol 3 (3) ◽  
pp. 59-61
Author(s):  
Michal Lebl
Keyword(s):  
High Throughput ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
New Approach ◽  
Phase Synthesis ◽  
Unlimited Number ◽  
Simultaneous Processing ◽  
Filtration Step ◽  
Liquid Removal

High throughput solid phase synthesis can be performed with application of the centrifugation based liquid removal. This technique uses readily available standard microtiterplates and eliminates filtration step. It is therefore applicable to simultaneous processing of unlimited number of reaction compartments. Its use is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones.

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