Dendrimers as Drug and Gene Delivery Systems

2006 ◽  
pp. 489-508
Author(s):  
Jong-Sang Park ◽  
Tae-il Kim
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Drug And Gene Delivery

scholarly journals Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 940
Author(s):  
Chaojie Zhu ◽  
Zhiheng Ji ◽  
Junkai Ma ◽  
Zhijie Ding ◽  
Jie Shen ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Treatment ◽  
Delivery Systems ◽  
Cancer Targeting ◽  
Cancer Treatments ◽  
Recent Advances ◽  
Therapeutic Mechanisms ◽  
Bacterial Therapy ◽  
Targeting Ability ◽  
Drug And Gene Delivery

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.

The effect of micro and nanotopography on endocytosis in drug and gene delivery systems

Biomaterials ◽  
2011 ◽  
Vol 32 (36) ◽  
pp. 9866-9875 ◽  
Author(s):  
Benjamin K.K. Teo ◽  
Seok-Hong Goh ◽  
Tanu S. Kustandi ◽  
Wei Wei Loh ◽  
Hong Yee Low ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Drug And Gene Delivery

The forthcoming applications of gold nanoparticles in drug and gene delivery systems

2011 ◽  
Vol 149 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Dakrong Pissuwan ◽  
Takuro Niidome ◽  
Michael B. Cortie
Keyword(s):  
Gold Nanoparticles ◽  
Gene Delivery ◽  
Delivery Systems ◽  
Drug And Gene Delivery

scholarly journals Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems

2020 ◽  
Vol 20 ◽  
Author(s):  
Chun Chan ◽  
Shi Du ◽  
Yizhou Dong ◽  
Xiaolin Cheng
Keyword(s):  
Gene Delivery ◽  
Research And Development ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Functional Information ◽  
Computational Approaches ◽  
The Us ◽  
Experimental Approaches ◽  
Reduced Toxicity ◽  
Drug And Gene Delivery

: Lipid nanoparticles (LNPs) have been widely applied for drug and gene delivery. More than twenty years ago, Doxil TM was the first LNPs-based drug approved by the US Food and Drug Administration (FDA). Since then, with decades of research and development, more and more LNP-based therapeutics have been used to treat diverse diseases, which often offer the benefits of reduced toxicity and/or enhanced efficacy compared to the active ingredients alone. Here, we provide a review on recent advances in the development of efficient and robust LNPs for drug/gene delivery. We emphasize the importance of rationally combining experimental and computational approaches, especially those providing multiscale structural and functional information of LNPs, to the design of novel and powerful LNP-based delivery systems.

Cyclodextrins and their Derivatives as Carrier Molecules in Drug and Gene Delivery Systems

2019 ◽  
Vol 23 (11) ◽  
pp. 1256-1269 ◽  
Author(s):  
Ramin Karimian ◽  
Milad Aghajani
Keyword(s):  
Gene Delivery ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Complexing Agents ◽  
Routes Of Administration ◽  
Naturally Occurring ◽  
Physico Chemical ◽  
Recent Developments ◽  
Major Emphasis ◽  
Drug And Gene Delivery

Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides containing six (α-CD), seven (β-CD), eight (γ-CD) and more glucopyranose units linked with α-(1,4) bonds, having a terminal hydrophilic part and central lipophilic cavity. α-, β- and γ-CDs are widely used in many industrial products, technologies and analytical methods owing to their unique, versatile and tunable characteristics. In the pharmaceutical industry, CDs are used as complexing agents to enhance aqueous solubility, physico-chemical stability and bio-availability of administered drugs. Herein, special attention is given to the use of α-, β- and γ-CDs and their derivatives in different areas of drug and gene delivery systems in the past few decades through various routes of administration with a major emphasis on the more recent developments.

scholarly journals Ligation Strategies for Targeting Liposomal Nanocarriers

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Patricia Marqués-Gallego ◽  
Anton I. P. M. de Kroon
Keyword(s):  
Gene Delivery ◽  
Diagnostic Imaging ◽  
Blood Circulation ◽  
Drug Carriers ◽  
Research Area ◽  
Delivery Systems ◽  
Active Targeting ◽  
Stealth Liposomes ◽  
Liposomal Formulations ◽  
Drug And Gene Delivery

Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealth liposomes, so called because they are equipped with a PEGylated coating of the liposome bilayer, leading to prolonged blood circulation and improved biodistribution of the liposomal carrier. A growing research area focuses on the preparation of liposomes with the ability of targeting specific tissues. Several strategies to prepare liposomes with active targeting ligands have been developed over the last decades. Herein, several strategies for the functionalization of liposomes are concisely summarized, with emphasis on recently developed technologies for the covalent conjugation of targeting ligands to liposomes.

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