Genetic Variability in Folate-Mediated One-Carbon Metabolism and Cancer Risk

2006 ◽  
pp. 75-91
Author(s):  
Cornelia M. Ulrich
Keyword(s):  
Genetic Variability ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

scholarly journals Supplemental one‐carbon metabolism related B vitamins and lung cancer risk in the Women's Health Initiative

2020 ◽  
Vol 147 (5) ◽  
pp. 1374-1384 ◽  
Author(s):  
Theodore M. Brasky ◽  
Roberta M. Ray ◽  
Sandi L. Navarro ◽  
Jeannette M. Schenk ◽  
Alison M. Newton ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Women's Health ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
B Vitamins ◽  
Women's Health Initiative ◽  
Health Initiative ◽  
One Carbon Metabolism ◽  
The Women’S Health Initiative

scholarly journals Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort

2017 ◽  
Vol 35 (30) ◽  
pp. 3440-3448 ◽  
Author(s):  
Theodore M. Brasky ◽  
Emily White ◽  
Chi-Ling Chen
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Lung Cancer Risk ◽  
Hazard Ratio ◽  
B Vitamins ◽  
Vitamin B ◽  
Supplement Use ◽  
One Carbon Metabolism

Purpose Inconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplement use relative to cancer risk. Methods A total of 77,118 participants of the VITAL cohort, 50 to 76 years of age, were recruited between October 2000 and December 2002 and included in this analysis. Incident, primary, invasive lung cancers (n = 808) were ascertained by prospectively linking the participants to a population-based cancer registry. The 10-year average daily dose from individual and multivitamin supplements were the exposures of primary interest. Results Use of supplemental vitamins B6, folate, and B12 was not associated with lung cancer risk among women. In contrast, use of vitamin B6 and B12 from individual supplement sources, but not from multivitamins, was associated with a 30% to 40% increase in lung cancer risk among men. When the 10-year average supplement dose was evaluated, there was an almost two-fold increase in lung cancer risk among men in the highest categories of vitamin B6 (> 20 mg/d; hazard ratio, 1.82; 95% CI, 1.25 to 2.65) and B12 (> 55µg/d; hazard ratio, 1.98; 95% CI, 1.32 to 2.97) compared with nonusers. For vitamin B6 and B12, the risk was even higher among men who were smoking at baseline. In addition, the B6 and B12 associations were apparent in all histologic types except adenocarcinoma, which is the type less related to smoking. Conclusion This sex- and source-specific association provides further evidence that vitamin B supplements are not chemopreventive for lung cancer and may be harmful.

Dietary factors of one-carbon metabolism and prostate cancer risk

2006 ◽  
Vol 84 (4) ◽  
pp. 929-935 ◽  
Author(s):  
Stephanie J Weinstein ◽  
Rachael Stolzenberg-Solomon ◽  
Pirjo Pietinen ◽  
Philip R Taylor ◽  
Jarmo Virtamo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Carbon Metabolism ◽  
Prostate Cancer Risk ◽  
Dietary Factors ◽  
One Carbon Metabolism

B-Vitamine und Lungenkrebsrisiko

2017 ◽  
Vol 49 (04) ◽  
pp. 195-197
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Clin Oncol ◽  
Carbon Metabolism ◽  
Vitamin B6 ◽  
Lung Cancer Risk ◽  
Vitamin B ◽  
One Carbon Metabolism

Brasky TM, White E, Cheng C-L. Long-term, supplemental, one-carbon metabolism-related vitamin B use in relation to lung cancer risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol 2017; 35: 3440–3448 Die jahrelange Einnahme von hoch dosierten Vitamin-B6- oder -B12-Einzelpräparaten ging in einer prospektiven Kohortenstudie bei älteren Männern mit einem stark erhöhten Lungenkrebsrisiko (2- bis 4-fach) einher.

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