Chemical Enhancers in Buccal and Sublingual Absorptions

2006 ◽  
Author(s):  
John Smart
Keyword(s):  
Chemical Enhancers

Enhancement of nortriptyline penetration through human epidermis: influence of chemical enhancers and iontophoresis

2008 ◽  
Vol 60 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Virginia Merino ◽  
Teresa Micó-Albiñana ◽  
Amparo Nácher ◽  
Octavio Díez-Sales ◽  
Marina Herráez ◽  
...  
Keyword(s):  
Human Epidermis ◽  
Chemical Enhancers

scholarly journals Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 534 ◽  
Author(s):  
Johanna Hettinga ◽  
Robert Carlisle
Keyword(s):  
Thermal Ablation ◽  
Influenza Pandemic ◽  
Vaccine Hesitancy ◽  
Vaccination Site ◽  
New Techniques ◽  
Diverse Range ◽  
Chemical Enhancers ◽  
Humoral And Cellular Immunity ◽  
Current State ◽  
Opening Up

In 2019, an ‘influenza pandemic’ and ‘vaccine hesitancy’ were listed as two of the top 10 challenges to global health by the WHO. The skin is a unique vaccination site, due to its immune-rich milieu, which is evolutionarily primed to respond to challenge, and its ability to induce both humoral and cellular immunity. Vaccination into this dermal compartment offers a way of addressing both of the challenges presented by the WHO, as well as opening up avenues for novel vaccine formulation and dose-sparing strategies to enter the clinic. This review will provide an overview of the diverse range of vaccination techniques available to target the dermal compartment, as well as their current state, challenges, and prospects, and touch upon the formulations that have been developed to maximally benefit from these new techniques. These include needle and syringe techniques, microneedles, DNA tattooing, jet and ballistic delivery, and skin permeabilization techniques, including thermal ablation, chemical enhancers, ablation, electroporation, iontophoresis, and sonophoresis.

scholarly journals Microneedle-Based Delivery: An Overview of Current Applications and Trends

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 569 ◽  
Author(s):  
Antonio José Guillot ◽  
Ana Sara Cordeiro ◽  
Ryan F. Donnelly ◽  
M. Carmen Montesinos ◽  
Teresa M. Garrigues ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Transdermal Delivery ◽  
Safety Data ◽  
Manufacturing Processes ◽  
Systemic Effects ◽  
Subcutaneous Injections ◽  
Chemical Enhancers ◽  
Current State ◽  
Microneedle Arrays ◽  
Physical Treatments

Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.

Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate

2005 ◽  
Vol 61 (1-2) ◽  
pp. 50-55 ◽  
Author(s):  
A. Femenía-Font ◽  
C. Balaguer-Fernández ◽  
V. Merino ◽  
V. Rodilla ◽  
A. López-Castellano
Keyword(s):  
Percutaneous Absorption ◽  
Chemical Enhancers ◽  
Sumatriptan Succinate ◽  
In Vitro Percutaneous Absorption
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