Self-Assembled Organic Nanotubes: Novel Bionanomaterials for Orthopedics and Tissue Engineering

2007 ◽  
pp. 35-56
Keyword(s):  
Tissue Engineering ◽  
Self Assembled ◽  
Organic Nanotubes

Self-Assembled Organic Nanotubes: Novel Bionanomaterials for Orthopedics and Tissue Engineering

2017 ◽  
pp. 19-46
Author(s):  
Rachel L. Beingessner ◽  
Baljit Singh ◽  
Thomas J. Webster ◽  
Hicham Fenniri
Keyword(s):  
Tissue Engineering ◽  
Self Assembled ◽  
Organic Nanotubes

Self-Assembled Organic Nanotubes: Novel Bionanomaterials for Orthopedics and Tissue Engineering

2017 ◽  
pp. 17-46
Author(s):  
Rachel L. Beingessner ◽  
Baljit Singh ◽  
Thomas J. Webster ◽  
Hicham Fenniri
Keyword(s):  
Tissue Engineering ◽  
Self Assembled ◽  
Organic Nanotubes

scholarly journals Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering

2011 ◽  
Vol 7 (5) ◽  
pp. 2244-2255 ◽  
Author(s):  
Muwan Chen ◽  
Dang Q.S. Le ◽  
Anette Baatrup ◽  
Jens V. Nygaard ◽  
San Hein ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Matrix ◽  
Self Assembled

Helical Rosette Nanotubes as a Potentially More Effective Orthopaedic Implant Material

2004 ◽  
Vol 845 ◽  
Author(s):  
Ai Lin Chun ◽  
Hicham Fenniri ◽  
Thomas J. Webster
Keyword(s):  
Tissue Engineering ◽  
Surface Roughness ◽  
Bone Cells ◽  
In Vitro Study ◽  
Orthopaedic Implant ◽  
Rosette Nanotubes ◽  
Osteoblast Adhesion ◽  
Organic Nanotubes ◽  
First Time

ABSTRACTOrganic nanotubes called helical rosette nanotubes (HRN) have been synthesized in this study for bone tissue engineering applications. They possess intriguing properties for various bionanotechnology applications since they can be designed to mimic the nanostructured constituent components in bone such as collagen fibers and hydroxyapatite (Ca5(PO4)3(OH)) which bone cells are naturally accustomed to interacting with. This is in contrast to currently used orthopaedic materials such as titanium which do not possess desirable nanometer surface roughness. The objective of this in vitro study was to determine bone-forming cell (osteoblasts) interactions on titanium coated with HRNs. Results of this study showed for the first time increased osteoblast adhesion on titanium coated with HRNs compared to those not coated with HRNs. In this manner, this study provided evidence that HRNs should be further considered for orthopaedic applications.

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

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