Recognition, prevention, and treatment of adverse effects associated with oral allergen immunotherapy

2020 ◽  
pp. 515-532
Author(s):  
Jennifer A. Dantzer ◽  
Robert A. Wood
Keyword(s):  
Adverse Effects ◽  
Allergen Immunotherapy ◽  
Prevention And Treatment

Efficacy and safety of rush immunotherapy with alumprecipitated allergens in canine atopic dermatitis

2014 ◽  
Vol 42 (03) ◽  
pp. 162-173
Author(s):  
Ralf Mueller ◽  
S. Hobi
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Allergen Immunotherapy ◽  
Specific Treatment ◽  
Small Animal ◽  
Common Disease ◽  
Efficacy And Safety ◽  
Canine Atopic Dermatitis ◽  
Rush Immunotherapy ◽  
Clinical Problems

Summary Objectives: Canine atopic dermatitis is a very common disease in small animal practice. Its only specific treatment is allergen immunotherapy. In rush-immunotherapy (RIT) increasing doses of allergen extract are injected subcutaneously in short intervals. Maintenance doses are achieved within one day compared to weeks or months with conventional immunotherapy. The aim of this study was to evaluate the safety and efficacy of RIT with alum-precipitated allergens. Materials and methods: A series of 20 dogs with atopic dermatitis underwent RIT with alum-precipitated allergens. Pruritus and medications at the start of the immunotherapy and 12 months afterwards were compared and adverse effects were recorded. Results: Significant improvement in pruritus (p = 0.0001) and medication scores (p = 0.0004) was noted after approximately 12 months of treatment. The observed clinical response was good to excellent in 70% of the dogs, consistent with other published reports. One dog vomited once during the induction day, with no other clinical problems and completion of the normal protocol. The other 19 dogs showed no adverse effects at all during or after RIT. Conclusion and clinical relevance: RIT with alum-precipitated allergens seems to be a safe and efficacious method to treat dogs with atopic dermatitis.

Role of Nutraceuticals in Cancer

2019 ◽  
pp. 388-406
Author(s):  
Kiran Dahiya ◽  
Rakesh Dhankhar
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Healthcare Professionals ◽  
Standard Treatment ◽  
Treatment Modalities ◽  
Active Components ◽  
Prevention And Treatment ◽  
Prevention Of Cancer

Nutraceuticals are increasingly becoming popular for prevention and treatment of cancer. Association of adverse effects with standard treatment modalities of cancer has led to consideration of safer approaches. Nutraceuticals may help in prevention of cancer as well as in treatment and avoidance of side effects associated with chemo-radiation. The active components of nutraceuticals are known as phytochemicals. Many mechanisms have been put forward for the actions of these phytochemicals but an exact mechanism for a well defined role of a particular phytochemical in a specific type of cancer is yet to be elucidated. Thus, nutraceutical industry has emerged as a research oriented sector. It is important for the healthcare professionals to understand the categories, research developments, mechanism of action and areas of concern in the field of nutraceuticals.

scholarly journals Adverse effects of hysteroscopy, prevention and treatment: literature review

2013 ◽  
Vol 2 ◽  
pp. 175-179
Author(s):  
Marcin Baum ◽  
Piotr Woźniak ◽  
Tomasz Stetkiewicz ◽  
Przemysław Oszukowski
Keyword(s):  
Literature Review ◽  
Adverse Effects ◽  
Prevention And Treatment

scholarly journals Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds

2021 ◽  
Author(s):  
Michael Adu-Frimpong ◽  
James Abugri ◽  
Bridget Osei Henewaah Annor
Keyword(s):  
Adverse Effects ◽  
Treatment Strategies ◽  
Clinical Findings ◽  
Folate Supplementation ◽  
Recent Advances ◽  
Prevention And Treatment ◽  
Life Threatening ◽  
Potent Drug

Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.

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